Why is "Anoikis" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-21 07:29:32
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
Anoikis is a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM). Usually cells stay close to the tissue to which they belong since the communication between proximal cells as well as between cells and ECM provide essential signals for growth or survival. When cells are detached from the ECM, there is a loss of normal cell–matrix interactions, and they may undergo anoikis. However, metastatic tumor cells may escape from anoikis and invade other organs.
Read more on Wikipedia →Related Topics
Trending Topic Today
Search Interest Perspective
-
NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy - Nature
-
Celastrol increases anoikis sensitivity to suppress triple-negative breast cancer via EGFR pathway and p-EMT state regulation - Frontiers
-
Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response | Oncogene - Nature
-
Identification of anoikis-related genes and immune infiltration characteristics in Sjögren’s syndrome based on machine learning - Frontiers
-
Targeting the Akt–EphA2 axis and cell–cell adhesion enhances anoikis sensitivity in cancer cells - Nature
-
YEATS2 promotes DNA repair and induces anoikis resistance by enhancing chromatin accessibility to drive prostate cancer metastasis | Oncogene - Nature
-
Analysis of the molecular subtypes and prognostic models of anoikis-related genes in colorectal cancer - Frontiers
-
PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2 - Nature
-
MUC13 is a crucial player in YAP1-β-catenin survival complex mediated cancer metastasis - Frontiers
-
Anoikis resistance in gastric cancer: a comprehensive review - Nature
-
Targeting integrin beta 4 in diacetyl-induced anoikis of the airway epithelium - Nature
-
CTTN overexpression in HNSCC inhibits Anoikis-apoptosis - Nature
-
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion - Nature
-
Identification and verification of SPP1 in anoikis as a prognostic biomarker for intestinal metaplasia and gastric cancer - Nature
-
Identification of STAT3 and BIRC5 as anoikis-related biomarkers in psoriasis - Nature
-
A novel anoikis related gene prognostic model for colorectal cancer based on single cell sequencing and bulk transcriptome analyses - Nature
-
Anoikis-related biomarkers PARP1 and SDCBP as diagnostic and therapeutic targets for asthma - Nature
-
ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance | Cell Death & Disease - Nature
-
ITGB6 promotes tumor recurrence and metastasis by mediating the resistance of daughter cells of PGCCs to anoikis - Nature
-
Elevated CD36 drives lymph node metastasis of breast cancer by activating Hippo-YAP signaling-mediated anoikis resistance - Nature
-
Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome - Frontiers
-
Correction: CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis - Nature
-
Endothelin receptor antagonists target EDNRB and modulate the progression of idiopathic pulmonary fibrosis via anoikis-related genes - Frontiers
-
Gene expression profile of anoikis reveals new subtypes of liver cancer and discovery of therapeutic targets and biomarkers - Nature
-
Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a - Nature
-
The anoikis-related gene signature predicts survival accurately in colon adenocarcinoma - Nature
-
Identification of Anoikis-related potential biomarkers and therapeutic drugs in chronic thromboembolic pulmonary hypertension via bioinformatics analysis and in vitro experiment - Nature
-
Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming - Frontiers
-
Development of a prognostic model for anoikis and identifies hub genes in hepatocellular carcinoma - Nature
-
Anoikis - Cell Death & Differentiation - Nature
-
Integration of Bulk RNA and Single‐Cell Analyses Reveal Distinct Expression Patterns of Anoikis‐Related Genes and the Immunosuppressive Role of NQO1+ Macrophages in Hepatocellular Carcinoma - Song - 2025 - Wiley
-
Anoikis-related gene signatures in colorectal cancer: implications for cell differentiation, immune infiltration, and prognostic prediction - Nature
-
Novel anoikis-related diagnostic biomarkers for aortic dissection based on machine learning - Nature
-
Anoikis-related genes signature development for clear cell renal cell carcinoma prognosis and tumor microenvironment - Nature
-
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin - Nature
-
Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma - Nature
-
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR - Nature
-
TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways - Nature
-
ABHD4-dependent developmental anoikis safeguards the embryonic brain - Nature
-
A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration - Frontiers
-
The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma - Frontiers
-
Anoikis in phenotypic reprogramming of the prostate tumor microenvironment - Frontiers
-
A prognostic model for anoikis-related genes in pancreatic cancer - Nature
-
Single-cell and bulk RNA sequencing reveals Anoikis related genes to guide prognosis and immunotherapy in osteosarcoma - Nature
-
NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR - Nature
-
Identification of anoikis-related subtypes and immune landscape in kidney renal clear cell carcinoma - Nature
-
Anoikis related genes may be novel markers associated with prognosis for ovarian cancer - Nature
-
Development of anoikis-related genes signature to predict the prognosis in gastric cancer patients - Frontiers
-
MUC1 O -glycosylation contributes to anoikis resistance in epithelial cancer cells - Nature
-
Understanding and targeting anoikis in metastasis for cancer therapies - Sattari Fard - 2023 - Cell Biology International - Wiley Online Library
-
Construction of an anoikis-associated lncRNA-miRNA-mRNA network reveals the prognostic role of β-elemene in non-small cell lung cancer - Nature
-
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD - Nature
-
Anoikis effector Bit1 negatively regulates Erk activity - PNAS
-
Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking - Nature
-
A novel anoikis-related gene signature predicts prognosis in patients with sepsis and reveals immune infiltration - Nature
-
Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future - Frontiers
-
The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis - Nature
-
MUC1 extracellular domain confers resistance of epithelial cancer cells to anoikis - Nature
-
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis - Nature
-
Integrin inhibition promotes atypical anoikis in glioma cells - Cell Death & Disease - Nature
-
Regulation of anoikis resistance by NADPH oxidase 4 and epidermal growth factor receptor - Nature
-
Deciphering anoikis resistance and identifying prognostic biomarkers in clear cell renal cell carcinoma epithelial cells - Nature
-
Anoikis resistance of small airway epithelium is involved in the progression of chronic obstructive pulmonary disease - Frontiers
-
Development of an anoikis-related gene signature and prognostic model for predicting the tumor microenvironment and response to immunotherapy in colorectal cancer - Frontiers
-
Integrin endosomal signalling suppresses anoikis - Nature
-
Scaphium affine Ethanol Extract Induces Anoikis by Regulating the EGFR/Akt Pathway in HCT116 Colorectal Cancer Cells - Frontiers
-
Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT - Nature
-
Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration - Nature
-
Cancer cell resistance to anoikis: MUC1 glycosylation comes to play - Nature
-
Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis - Nature
-
An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers - Frontiers
-
Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis - Nature
-
Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival - Nature
-
Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines - Nature
-
SERPINE1 Facilitates Metastasis in Gastric Cancer Through Anoikis Resistance and Tumor Microenvironment Remodeling - Wiley Online Library
-
An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530) - Nature
-
Modified Anoikis Assay That Functionally Segregates Epstein-Barr Virus LMP1 Strains into Two Groups - ASM Journals
-
A signature based on anoikis-related genes for the evaluation of prognosis, immunoinfiltration, mutation, and therapeutic response in ovarian cancer - Frontiers
-
Tumor Suppressor DAPK1 Catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices - Frontiers
-
Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells - Nature
-
p14ARF interacts with the focal adhesion kinase and protects cells from anoikis - Nature
-
Anoikis-related genes combined with single cell sequencing: Insights into model specification of lung adenocarcinoma and applicability for prognosis and therapy - Frontiers
-
Anoikis-related long non-coding RNA signatures to predict prognosis and small molecular drug response in cervical cancer - Frontiers
-
Anoikis in cell fate, physiopathology, and therapeutic interventions - Mei - 2024 - MedComm - Wiley Online Library
-
Deciphering hepatocellular carcinoma pathogenesis and therapeutics: a study on anoikis, ceRNA regulatory network and traditional Chinese medicine - Frontiers
-
The ZNF304-integrin axis protects against anoikis in cancer - Nature
-
Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis - Nature
-
Predicting the immune microenvironment and prognosis with a anoikis - related signature in breast cancer - Frontiers
-
Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK - Nature
-
A novel anoikis-related gene signature identifies LYPD1 as a novel therapy target for bladder cancer - Nature
-
Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF) - Nature
-
A novel signature for predicting prognosis and immune landscape in cutaneous melanoma based on anoikis-related long non-coding RNAs - Nature
-
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB - Nature
-
Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner - Nature
-
A novel stratification framework based on anoikis-related genes for predicting the prognosis in patients with osteosarcoma - Frontiers
-
Restoration of sensitivity to anoikis in Ras-transformed rat intestinal epithelial cells by a Ras inhibitor - Nature
-
Polo-like kinase 4 (Plk4) potentiates anoikis -resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype - Nature
-
The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells - Nature
-
RETRACTED ARTICLE: Autophagy-independent induction of LC3B through oxidative stress reveals its non-canonical role in anoikis of ovarian cancer cells | Cell Death & Disease - Nature
-
A novel risk model based on anoikis: Predicting prognosis and immune infiltration in cutaneous melanoma - Frontiers
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.