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Antiarigenin is a highly toxic cardenolide aglycone found in the latex of Antiaris toxicaria (upas tree). As the steroid core of α-antiarin and β-antiarin glycosides, it has been used for centuries by indigenous peoples of Southeast Asia in blowdart arrow poisons. It functions as a potent Na+/K+-ATPase inhibitor and has shown potential to induce apoptosis in chemotherapy-resistant cancer cells through orphan nuclear receptor Nur77 modulation.
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