Why is "Arcuate nucleus (hypothalamus)" trending?
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- Date: 2026-03-18 00:51:14
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Wikipedia Overview
The arcuate nucleus of the hypothalamus (ARH), or ARC, is also known as the infundibular nucleus to distinguish it from the arcuate nucleus of the medulla oblongata in the brainstem. The arcuate nucleus is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important and diverse populations of neurons that help mediate different neuroendocrine and physiological functions, including neuroendocrine neurons, centrally projecting neurons, and astrocytes. The populations of neurons found in the arcuate nucleus are based on the hormones they secrete or interact with and are responsible for hypothalamic function, such as regulating hormones released from the pituitary gland or secreting their own hormones. Neurons in this region are also responsible for integrating information and providing inputs to other nuclei in the hypothalamus or inputs to areas outside this region of the brain. These neurons, generated from the ventral part of the periventricular epithelium during embryonic development, locate dorsally in the hypothalamus, becoming part of the ventromedial hypothalamic region. The function of the arcuate nucleus relies on its diversity of neurons, but its central role is involved in homeostasis. The arcuate nucleus provides many physiological roles involved in feeding, metabolism, fertility, and cardiovascular regulation.
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Search Interest Perspective
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The Hypothalamic Arcuate Nucleus Dopaminergic Neurons - Endocrine.org
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Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis - Nature
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Endogenous amylin contributes to birth of microglial cells in arcuate nucleus of hypothalamus and area postrema during fetal development - American Physiological Society Journal
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Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus - Journal of Neuroscience
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Integration of Nutrient Sensing in Fish Hypothalamus - Frontiers
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Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model - Nature
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Arcuate Nucleus-Dependent Regulation of Metabolism - Endocrine.org
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Deletion of Stim1 in Hypothalamic Arcuate Nucleus Kiss1 Neurons Potentiates Synchronous GCaMP Activity and Protects against Diet-Induced Obesity - Journal of Neuroscience
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Perinatal Western-style diet exposure associated with decreased microglial counts throughout the arcuate nucleus of the hypothalamus in Japanese macaques - American Physiological Society Journal
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Pathogenic hypothalamic extracellular matrix promotes metabolic disease - Nature
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Dopamine/Tyrosine Hydroxylase Neurons of the Hypothalamic Arcuate Nucleus Release GABA, Communicate with Dopaminergic and Other Arcuate Neurons, and Respond to Dynorphin, Met-Enkephalin, and Oxytocin - Journal of Neuroscience
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Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss - Nature
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Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting - Nature
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Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators - Nature
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Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice - Nature
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Perineuronal net formation during the critical period for neuronal maturation in the hypothalamic arcuate nucleus - Nature
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Src activation in the hypothalamic arcuate nucleus may play an important role in pain hypersensitivity - Nature
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Neuroscience: Dissecting appetite - Nature
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Enhanced NMDA receptor NR1 phosphorylation and neuronal activity in the arcuate nucleus of hypothalamus following peripheral inflammation - Nature
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Knockdown of Tlr4 in the Arcuate Nucleus Improves Obesity Related Metabolic Disorders - Nature
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Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus - Journal of Neuroscience
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Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight - Nature
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Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus - Journal of Neuroscience
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Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits | Molecular Psychiatry - Nature
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Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice | Gene Therapy - Nature
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Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice - Wiley
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Formation of Projection Pathways from the Arcuate Nucleus of the Hypothalamus to Hypothalamic Regions Implicated in the Neural Control of Feeding Behavior in Mice - Journal of Neuroscience
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Murine Arcuate Nucleus Kisspeptin Neurons Communicate with GnRH Neurons In Utero - Journal of Neuroscience
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Researchers reveal the connection between hypothalamus and pancreas - Institute for Research in Biomedicine | IRB Barcelona
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Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus - Nature
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Specialised nerve cells increase the appetite for high-fat foods - Max-Planck-Gesellschaft zur Förderung der Wissenschaften
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Marc Claret: "This discovery may have an implication for diseases such as diabetes" - Institute for Research in Biomedicine | IRB Barcelona
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