Why is "Arginine:glycine amidinotransferase" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-03-17 14:27:13
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
L-Arginine:glycine amidinotransferase is the enzyme that catalyses the transfer of an amidino group from L-arginine to glycine. The products are L-ornithine and glycocyamine, also known as guanidinoacetate, the immediate precursor of creatine. Creatine and its phosphorylated form play a central role in the energy metabolism of muscle and nerve tissues. Creatine is in highest concentrations in the skeletal muscle, heart, spermatozoa and photoreceptor cells. Creatine helps buffer the rapid changes in ADP/ATP ratio in muscle and nerve cells during active periods. Creatine is also synthesized in other tissues, such as pancreas, kidneys, and liver, where amidinotransferase is located in the cytoplasm, including the intermembrane space of the mitochondria, of the cells that make up those tissues.
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Search Interest Perspective
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Teaching NeuroImage: A 6-Month-Old Boy With Arginine-Glycine Amidinotransferase Deficiency - Neurology® Journals
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Arginine’s roles and metabolic edge over guanidinoacetic acid - All About Feed
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Expression of cardiovascular-related microRNAs is altered in L-arginine:glycine amidinotransferase deficient mice - Nature
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Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia - Frontiers
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Cerebral Creatine Deficiency Syndrome Research Center - School of Medicine | University of Utah
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Analysis of L-arginine:glycine amidinotransferase-, creatine- and homoarginine-dependent gene regulation in the murine heart - Nature
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Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure - Wiley Online Library
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Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas - Cambridge University Press & Assessment
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Influence of homoarginine on creatine accumulation and biosynthesis in the mouse - Frontiers
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Symptoms of creatine deficiency syndrome. Case report | Lemska | Child Neurology — Neurologia Dziecięca - Via Medica Journals
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Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction - Nature
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Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations - Nature
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A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2 - Nature
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The Arginine-Creatine Pathway is Disturbed in Children and Adolescents With Renal Transplants - Nature
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Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice – differences between models, muscles, and sexes - Nature
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Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics - Nature
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