Why is "Arrestin" trending?

Search Interest Perspective

• Functional and structural insights into interactions between β-Arrestin 1 and Gαs or Gαi1 - Nature
• Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1 - Science | AAAS
• β-arrestins emerge as targets for precision peptide drug design - Labmate Online
• Arrestin recognizes GPCRs independently of the receptor state - PNAS
• Beta arrestin 1 emerges as key driver of pulmonary hypertension - News-Medical
• Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation - Nature
• Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis - Nature
• Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy - Nature
• Molecular mechanism of β-arrestin 2 interaction with phosphorylated intracellular loop 3 of dopamine receptor D2 - Nature
• Gz and β-arrestin 1 signaling in the μ-opioid receptor - Cell Research - Nature
• Distinct membrane binding properties of the two non-visual arrestins | Communications Biology - Nature
• Novel atypical G protein-coupled receptor (GPCR)-arrestin complexes: a structural snapshot of the barcode hypothesis - Nature
• Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode - Nature
• R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes - Nature
• Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex - Nature
• A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor | Communications Chemistry - Nature
• Lipids modulate the dynamics of GPCR:β-arrestin interaction - Nature
• Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation - Nature
• Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P - Nature
• Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor - Nature
• A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors - PNAS
• Rsp5-mediated ubiquitination of a functional analog of the Rim8 arrestin facilitates Rim pathway activation in Cryptococcus neoformans . mBio - ASM Journals
• Biased signaling of chemokine receptor CCR1 in asthma - ERS - European Respiratory Society
• Rsp5-mediated ubiquitination of a functional analog of the Rim8 arrestin facilitates Rim pathway activation in Cryptococcus neoformans - ASM Journals
• Fluorescent biosensors for dynamic analysis of GPCR and arrestin interactions - News-Medical
• Chemerin receptor structures disclose new mechanism of lipid metabolism - Medical Xpress
• Video of masked ICE arrest in Redmond sparks push for ‘No Secret Police’ rules - KING5.com
• Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors - Science | AAAS
• Distinct activation mechanisms of β-arrestin-1 revealed by - Nature
• Functional specialization of β-arrestin interactions revealed by proteomic analysis - PNAS
• Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator - Nature
• Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3 - Nature
• Tail engagement of arrestin at the glucagon receptor - Nature
• Myosin VI drives arrestin-independent internalization and signaling of GPCRs - Nature
• Britney Spears Will “Take the Right Steps and Comply With the Law” After “Inexcusable” Arrest, Rep Says - hollywoodreporter.com
• G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling - Science | AAAS
• Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes - Nature
• Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody - Nature
• Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR - Nature
• Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells - Nature
• Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers - Science | AAAS
• β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR - Nature
• GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation - Nature
• Structure of the neurotensin receptor 1 in complex with β-arrestin 1 - Nature
• Arrest in major Rocky Mount drug bust - CBS17.com
• Structural basis of arrestin-3 activation and signaling - Nature
• Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor - Nature
• Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis - Nature
• Noncanonical scaffolding of Gαi and β-arrestin by G protein–coupled receptors - Science | AAAS
• Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2 - Nature
• Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin - PNAS
• Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference - PNAS
• Lack of beta-arrestin signaling in the absence of active G proteins - Nature
• Enveric Advances Lead Drug With New Findings On Key Brain Receptor Signals - Enveric Biosciences (NASDAQ - Benzinga
• Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling - Science | AAAS
• GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism - Nature
• Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation - Nature
• LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1 - Nature
• Dynamic mechanism of GPCR-mediated β-arrestin: a potential therapeutic agent discovery of biased drug - Nature
• The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases - Nature
• Catalytic activation of β-arrestin by GPCRs - Nature
• Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc - Nature
• C-edge loops of arrestin function as a membrane anchor - Nature
• β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity - Nature
• TF-FVIIa PAR2-β-Arrestin Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection of Mice - American Heart Association Journals
• β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells - Nature
• Quantifying the Kinetics of Signaling and Arrestin Recruitment by Nervous System G-Protein Coupled Receptors - Frontiers
• Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias - Nature
• β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling - Nature
• Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET - Nature
• Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure - American Heart Association Journals
• β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions - Nature
• Metabolic Functions of G Protein-Coupled Receptors and β-Arrestin-Mediated Signaling Pathways in the Pathophysiology of Type 2 Diabetes and Obesity - Frontiers
• RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi - PNAS
• Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor - Nature
• Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds - PNAS
• β‐arrestin 2 negatively regulates lung cancer progression by inhibiting the TRAF6 signaling axis for NF-κB activation and autophagy induced by TLR3 and TLR4 - Nature
• Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin - PNAS
• A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling - Nature
• β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion - Nature
• Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3 - Nature
• Therapeutic Potential of Targeting ß-Arrestin - Frontiers
• Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 - PNAS
• Molecular mechanism of GPCR-mediated arrestin activation - Nature
• AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330 - American Heart Association Journals
• Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex - Nature
• Functional competence of a partially engaged GPCR–β-arrestin complex - Nature
• A complex structure of arrestin-2 bound to a G protein-coupled receptor - Cell Research - Nature
• Arrestin Facilitates Rhodopsin Dephosphorylation in Vivo - Journal of Neuroscience
• Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy - PNAS
• signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent - Science | AAAS
• β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors - PNAS
• Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314 - Nature
• GPCRs and β-arrestins — an on-off relationship - Nature
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser - Nature
• Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders - Frontiers
• Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation - Nature
• VPS26 Moonlights as a β-Arrestin-like Adapter for a 7-Transmembrane RGS Protein in Arabidopsis thaliana - ACS Publications
• DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl - Nature
• Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor - PNAS