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Avian leukosis virus (ALV) is a retrovirus that infects chickens and causes a B-cell lymphoma. Some forms are present as an endogenous retrovirus and can spread vertically (parent-to-chick) while others only spread horizontally. Lymphoid leukosis is the most common form of this disease and with typical presentation of gradual onset, persistent low mortality, and neoplasia of the bursa. The disease is also characterized by an enlarged liver due to infiltration of cancerous lymphoid cells. In addition, other abdominal organs and the bursa of Fabricius are often infected. Experimentally it can infect other species of birds and mammals. Cladistically it includes viruses that naturally infect species other than chickens.
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