Why is "BRCA2" trending?

Search Interest Perspective

• The breakome of BRCA1 and BRCA2 pathway mutation carriers reveals early processes in breast oncogenesis - Nature
• Survival Outcomes With or Without Bilateral Risk-Reducing Mastectomy in BRCA1/BRCA2 Pathogenic Variant Carriers - The ASCO Post
• FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments - Science | AAAS
• 30 Years of BRCA2: From Gene Discovery to Clinical Impact - Oncodaily
• CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors - Frontiers
• Linitis Plastica in a Patient With a BRCA2 Mutation: A Case Report - Cureus
• Managing elevated cancer risk in BRCA+ men - Penn Medicine
• BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function - PNAS
• Breakthrough in BRCA2 research: a novel mechanism behind chemoresistance discovered - EurekAlert!
• Oxidative stress may suppress cancer onset in individuals with BRCA2 gene variants - Medical Xpress
• BRCA2 c.156_157insAlu Founder Variant in Northern Portugal: An Insight Into Hereditary Breast and Ovarian Cancer Genetic Risk and Management - Wiley Online Library
• A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature
• Men with BRCA1 and BRCA2 gene mutations should get annual prostate cancer screening - The Institute of Cancer Research
• FDA Approves Regimen for BRCA2-Mutated Metastatic Castration-Sensitive Prostate Cancer - The ASCO Post
• BRCA1 and BRCA2 gene expression: p53- and cell cycle-dependent repression requires RB and DREAM - Nature
• A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2 - Nature
• Evaluation of quantitative polymerase chain reaction for detecting BRCA1 or BRCA2 copy number loss in high-grade serous ovarian cancer - Nature
• Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination - Nature
• Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification - Nature
• HEARD: Melissa on family, BRCA2 and empowerment - Northside Hospital
• Study uncovers novel role for BRCA2, suggesting new therapeutic strategies - UT MD Anderson
• Identifying a breast cancer gene – BRCA2 - The Institute of Cancer Research
• Functional evaluation and clinical classification of BRCA2 variants - Nature
• BCRF-Supported Study Clarifies Risk Potential for 7,000 BRCA2 Variants - Breast Cancer Research Foundation | BCRF
• MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes - National Cancer Institute (.gov)
• Reduced penetrance BRCA1 and BRCA2 pathogenic variants in clinical germline genetic testing - Nature
• What to know after learning you have a BRCA mutation - UT MD Anderson
• BOADICEA model: updates to the BRCA2 breast cancer risks for ages 60 years and older - Nature
• Discovering the BRCA2 gene – 25 years on - Cancer Research UK - Cancer News
• Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations - Nature
• Researchers Reclassify Hundreds of BRCA2 Variants Linked to Cancer - Breast Cancer.org
• Do Female BRCA2 Pathogenic Variant Carriers Have an Increased Risk of Lung Cancer? - ASCO Publications
• 5 Things to Know about BRCA Mutations and Pancreatic Cancer - Pancreatic Cancer Action Network
• Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant - Nature
• Iit Madras: Indian Institute of Technology Madras study reveals need for broader breast cancer testing in India as commonly tested BRCA1 and BRCA2 genes account for less than 8% of cases | Chennai News - The Times of India
• A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination - Nature
• Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers - Nature
• BRCA1 and BRCA2 pathogenic variants and prostate cancer risk: systematic review and meta-analysis - Nature
• BRCA1 and BRCA2 Gene Mutations in Reproductive-Aged Women With Polycystic Ovarian Syndrome - Cureus
• Copy number variants as modifiers of breast cancer risk for BRCA1 BRCA2 pathogenic variant carriers - Nature
• Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status - Nature
• Gene-specific machine learning for pathogenicity prediction of rare BRCA1 and BRCA2 missense variants - Nature
• The tumor mutational landscape of BRCA2 -deficient primary and metastatic prostate cancer - Nature
• BRCA1 and BRCA2 genes mutations among high risk breast cancer patients in Jordan - Nature
• Saturation genome editing-based clinical classification of BRCA2 variants - Nature
• Large Study Verifies Cancer Risk for Women Carrying BRCA1 or BRCA2 Mutations - National Cancer Institute (.gov)
• Risk-benefits assessment of tamoxifen or raloxifene as chemoprevention for risk reduction of breast cancer among BRCA1 and BRCA2 carriers: a meta-analysis - Nature
• Researchers resolve uncertainty in BRCA2 testing, improving cancer risk assessment and patient care - Mayo Clinic News Network
• Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells - Nature
• Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 mutations according to molecular subtypes - Nature
• The cancer risk implications of the BRCA gene in men | BCRF - Breast Cancer Research Foundation | BCRF
• High-throughput functional evaluation of BRCA2 variants of unknown significance - Nature
• Inherited Cancer Risk: BRCA Mutation - Johns Hopkins Medicine
• Respirology Case Reports | APSR Respiratory Medicine Journal - Wiley Online Library
• Adjuvant Olaparib for Patients with BRCA1 - or BRCA2 -Mutated Breast Cancer - NEJM
• Essential Role of BRCA2 in Ovarian Development and Function - NEJM
• BRCA2 mutations in familial breast cancer with prostate cancer: a case report and literature review - Frontiers
• BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors - Nature
• A mother and daughter’s journey with BRCA2 gene mutations - Roswell Park Comprehensive Cancer Center
• Understanding Why BRCA2 Is Linked to Cancer Risk - UC Davis College of Biological Sciences
• BRCA1 and BRCA2 Mutations: What We Know Today - Fox Chase Cancer Center
• BRCA mutations in men: Three things to know - Penn Medicine
• Women with genetic mutations fare no worse with breast or ovarian cancer, study finds - Stanford Medicine
• Familial history and prevalence of BRCA1 BRCA2 and TP53 pathogenic variants in HBOC Brazilian patients from a public healthcare service - Nature
• brca2 -mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury - Nature
• The known genetic variants of BRCA1 BRCA2 and NOD2 in pancreatitis and pancreatic cancer risk assessment - Nature
• Risk of metastasis in BRCA2 carriers diagnosed with triple‐negative breast cancer - Moreno - 2023 - Cancer Medicine - Wiley Online Library
• Prevalence and predictors of germline BRCA1 and BRCA2 mutations among young patients with breast cancer in Jordan - Nature
• New Data Brings Clarity to Rare BRCA2 Mutations - Breast Cancer Research Foundation | BCRF
• Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories - Nature
• For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment - Memorial Sloan Kettering Cancer Center
• Newfound Role for Cancer Gene Could Improve Key Drug Class - NYU Langone Health
• Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy - Nature
• The influence of BRCA2 mutation on localized prostate cancer - Nature
• New insight into BRCA2 gene mutations and cancer risk - Drug Target Review
• The IMPACT of BRCA2 in prostate cancer - Nature
• The landscape of BRCA1 and BRCA2 large rearrangements in an international cohort of over 20 000 ovarian tumors identified using next-generation sequencing - Wiley Online Library
• Poor Outcomes of CDK4/6 Inhibitors in BRCA-Mutant Breast Cancer: What Mechanisms Might Be Responsible? - ASCO Daily News
• Clinical testing of BRCA1 and BRCA2 : a worldwide snapshot of technological practices - Nature
• Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations - NEJM
• Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers - Science | AAAS
• Next-generation sequencing based detection of BRCA1 and BRCA2 large genomic rearrangements in Chinese cancer patients - Frontiers
• The functional impact of variants of uncertain significance in BRCA2 - Nature
• A BRCA2 germline mutation and high expression of immune checkpoints in a TNBC patient | Cell Death Discovery - Nature
• Risk of Second Primary Cancers After Breast Cancer in BRCA1 and BRCA2 Pathogenic Variant Carriers - The ASCO Post
• Mutations in BRCA1 BRCA2 , and PALB2 , and a panel of 50 cancer-associated genes in pancreatic ductal adenocarcinoma - Nature
• BRCA1 and BRCA2: different roles in a common pathway of genome protection - Nature
• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures - Nature
• BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview - Frontiers
• Segregation analysis of the BRCA2 c.9227G>T variant in multiple families suggests a pathogenic role in breast and ovarian cancer predisposition - Nature
• BRCA2 mutation in advanced lung squamous cell carcinoma treated with Olaparib and a PD-1 inhibitor: a case report - Frontiers
• Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations - Nature
• Breastfeeding Cuts Ovarian Cancer Risk in BRCA Mutation Carriers - Cleveland Clinic
• Improvements in BRCA2 Testing Could Enhance Cancer Risk Assessment, Patient Care - The ASCO Post
• Breast Cancer Genes: What Are They, Types & Testing - Cleveland Clinic Health Essentials
• Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions - Nature
• BRCA2 : a 25-year journey from gene identification to targeted cancer treatment - The Lancet
• Risk-Reducing Salpingo-oophorectomy in Women with a BRCA1 or BRCA2 Mutation - NEJM
• A Glitch in a Molecular Repair Tool May Help Halt Some Breast Cancers - NYU Langone Health
• Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism - Frontiers