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The Bainbridge reflex is a cardiovascular reflex causing an increase in heart rate in response to increased stretching of the wall of the right atrium and/or the inferior vena cava as a result of increased venous filling. It is detected by stretch receptors in the wall of the right atrium, the afferent limb is via the vagus nerve, it is regulated by a center in the medulla oblongata of the brain, and the efferent limb involves reduced vagal activity and increased sympathetic nervous system outflow.
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