Why is "Binding site" trending?

Search Interest Perspective

• Extra-helical allosteric binding site of apomorphine in ADGRG6 - Cell Discovery - Nature
• N-Terminal Actin-Binding Site of Lmod2 Promotes Controlled Pointed End Elongation | Circulation Research - American Heart Association Journals
• Molecular basis for occlusion of the jeilongvirus receptor-binding site by the elongated C-terminus - ASM Journals
• A new perspective on betaine: Targeting the glycine binding site of the NMDA receptor - ScienceDirect.com
• Decoding efficacy and resistance space at a drug binding site - Nature
• A binding site for the antibiotic GE81112 in the ribosomal mRNA channel - ASM Journals
• Enhancing the detection of tetracycline antibiotics based on carbazole N - ScienceDirect.com
• Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis - frontiersin.org
• Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor - Nature
• Allelic dropout in the endoglin (ENG) gene caused by common duplication beyond the primer binding site - frontiersin.org
• Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site - Nature
• Structural insight into the unexploited allosteric binding site of fructose 1, 6-bisphosphate aldolase from C. albicans with α-lipoic acid - ScienceDirect.com
• Designing small molecules targeting a cryptic RNA binding site through base displacement - Nature
• Cryo-EM reveals an extrahelical allosteric binding site at the M - Nature
• An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies - Nature
• Revealing the location and dynamics of a concealed binding site in the dopamine transporter - Nature
• A potent and broad CD4 binding site neutralizing antibody with strong ADCC activity from a Chinese HIV-1 elite neutralizer - Nature
• Coevolving residues distant from the ligand binding site are involved in GAF domain function - Nature
• Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding site - Nature
• Comprehensive detection and characterization of human druggable pockets through binding site descriptors - Nature
• Highly accurate carbohydrate-binding site prediction with DeepGlycanSite - Nature
• Enhancing the interpretability of transcription factor binding site prediction using attention mechanism - Nature
• High-resolution landscape of an antibiotic binding site - Nature
• Fighting pain: the structure of gabapentin and its binding site in the Ca - Nature
• Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data - The Lancet
• A threading-based method (FINDSITE) for ligand-binding site prediction and functional annotation - PNAS
• A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 - Nature
• Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors - Nature
• Identification of a binding site for small molecule inhibitors targeting human TRPM4 - Nature
• Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis - Nature
• Dual modality feature fused neural network integrating binding site information for drug target affinity prediction - Nature
• ScanNet: an interpretable geometric deep learning model for structure-based protein binding site prediction - Nature
• Thermo Fisher will buy The Binding Site for $2.6B to gain specialty diagnostics portfolio - MedTech Dive
• Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif - PNAS
• Transcription factor binding site orientation and order are major drivers of gene regulatory activity - Nature
• The promise of priming precursors: Advances in inducing CD4 binding site–directed HIV broadly neutralizing antibodies - Science | AAAS
• Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance - Nature
• NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor - PNAS
• Identification of a ligand-binding site on tubulin mediating the tubulin–RB3 interaction - PNAS
• Indirect activation of a plant nucleotide binding site–leucine-rich repeat protein by a bacterial protease - PNAS
• Thermo Fisher Strikes $2.6B Deal to Acquire Diagnostics Company The Binding Site - Inside Precision Medicine
• Thermo Fisher ties up $2.6B deal for cancer diagnostics maker The Binding Site - Fierce Biotech
• Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer - PNAS
• Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains - Nature
• Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses - Nature
• A Heteromodal Word-Meaning Binding Site in the Visual Word Form Area under Top-Down Frontoparietal Control - Journal of Neuroscience
• Atomic level computational identification of ligand migration pathways between solvent and binding site in myoglobin - PNAS
• Thermo Fisher to buy diagnostics firm Binding Site for $2.6 bln - Reuters
• New ligand binding site identified through computer simulations - Drug Target Review
• Identification and functional characterization of a novel binding site on TNF-α promoter - PNAS
• Mapping the elusive neonicotinoid binding site - PNAS
• Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4 - Nature
• binding site critical in regulating ion transport - Nature
• CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals - Science | AAAS
• A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes - Nature
• A zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin - PNAS
• Identification of a chloride ion binding site in Na+/Cl−-dependent transporters - PNAS
• HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design - Nature
• Comparative analysis, diversification, and functional validation of plant nucleotide-binding site domain genes - Nature
• Protein Binding Site Representation in Latent Space - Lohmann - 2025 - Molecular Informatics - Wiley Online Library
• Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter - Nature
• Effect of histidine protonation state on ligand binding at the ATP-binding site of human protein kinase CK2 - Nature
• Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept - PNAS
• Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach - Nature
• Modelling ligand depletion for simultaneous affinity and binding site quantification on cells and tissue - Nature
• Sensational site: the sodium pump ouabain-binding site and its ligands - American Physiological Society Journal
• Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome - PNAS
• Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation - Nature
• The dsRNA binding site of human Toll-like receptor 3 - PNAS
• Extra-helical binding site of a glucagon receptor antagonist - Nature
• The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome - PNAS
• Exploring the ATP-binding site of P2X receptors - frontiersin.org
• Thermo Fisher Scientific Completes Acquisition of The Binding Site Group - BioPharma APAC
• An alternate binding site for PPARγ ligands - Nature
• An allosteric ligand-binding site in the extracellular cap of K2P channels - Nature
• The STIM1-binding site nexus remotely controls Orai1 channel gating - Nature
• Arf GTPase activates the WAVE regulatory complex through a distinct binding site - Science | AAAS
• Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5’ untranslated region - Nature
• LRF Binding Site as Potential Therapeutic Target for β-Hemoglobinopathies - Hematology Advisor
• A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity - Science | AAAS
• Evolution of a SHOOTMERISTEMLESS transcription factor binding site promotes fruit shape determination - Nature
• The binding protein of corticotropin-releasing factor: Ligand-binding site and subunit structure - PNAS
• Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase - Nature
• Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor - PNAS
• A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity - Science | AAAS
• Importance of OsRac1 and RAI1 in signalling of nucleotide-binding site leucine-rich repeat protein-mediated resistance to rice blast disease - nph.onlinelibrary.wiley.com
• Substrate binding site flexibility of the small heat shock protein molecular chaperones - PNAS
• From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor - PNAS
• Structural identification of riluzole-binding site on human TRPC5 - Nature
• Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists - Nature
• Efficient engineering of chromosomal ribosome binding site libraries in mismatch repair proficient Escherichia coli - Nature
• Researchers develop highly accurate carbohydrate binding site prediction algorithm, DeepGlycanSite - Phys.org
• Identification of a Divalent Metal Cation Binding Site in Herpes Simplex Virus 1 (HSV-1) ICP8 Required for HSV Replication - ASM Journals
• Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses - Science | AAAS
• Low pH structure of heliorhodopsin reveals chloride binding site and intramolecular signaling pathway - Nature
• Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly - PNAS
• A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association - Nature
• receptor models identify new benzodiazepine binding-site ligands - Nature
• A synthetic mimic of a discontinuous binding site on interleukin-10 - Nature
• Identification of a New Cholesterol-Binding Site within the IFN- γ Receptor that is Required for Signal Transduction - Wiley