Why is "Brain metastasis" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-21 05:07:52
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. The metastasis typically shares a cancer cell type with the original site of the cancer. Metastasis is the most common cause of brain cancer, as primary tumors that originate in the brain are less common. The most common sites of primary cancer which metastasize to the brain are lung, breast, colon, kidney, and skin cancer. Brain metastases can occur months or even years after the original or primary cancer is treated. Brain metastases have a poor prognosis for cure, but modern treatments allow patients to live months and sometimes years after the diagnosis.
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Trending Topic Today
Search Interest Perspective
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New discovery on brain metastasis reveals how tumors hijack immune cells to use them to their advantage - Centro Nacional de Investigaciones Oncológicas - CNIO
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Blood biomarker points to increased risk of brain metastasis in patients with inflammatory breast cancer - UT MD Anderson
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MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis - Nature
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Why Do Some Breast Cancers Spread to the Brain? - Breast Cancer.org
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Serum S100A8/S100A9 is associated with increased risk of brain metastasis in patients with inflammatory breast cancer - medRxiv
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CD74⁺ microglia/macrophages surrounding and infiltrating experimental brain metastasis [IMAGE] - EurekAlert!
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Case Report: Rare meets rare—miliary prostate cancer brain metastasis - Frontiers
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Managing Side Effects for Brain Metastasis in HER2+ Breast Cancer - Cure Today
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Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression - Wiley
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Hemiballismus as the Initial Manifestation of Brain Metastasis: Diagnostic Discordance Between PET-CT and MRI in a Patient With Multiple Neoplasms - Cureus
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Soluble E-cadherin drives brain metastasis in aggressive inflammatory breast cancer - News-Medical
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Guideline Recommendations and Imaging for Detection of Brain Metastasis - Targeted Oncology
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Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses - Nature
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Manuel Valiente, head of the Brain Metastasis group at the Spanish National Cancer Research Centre (CNIO). - EurekAlert!
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Editorial: Brain metastasis and systemic target therapy: implications for neurosurgeons - Frontiers
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Brain Metastasis After Curative Resection of Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis - Cureus
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Correction: GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway - Nature
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Brain metastasis from non-small cell lung cancer: crosstalk between cancer cells and tumor microenvironment components - Nature
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Metabolic adaptations of brain metastasis - Nature
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Association of sarcopenia with survival and treatment response in brain metastasis of non-small cell lung cancer - Nature
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From 6 Months to 5 Years: The New Era of Brain Metastasis Survival - Targeted Oncology
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HER3-DXd Yields Activity in NSCLC, Breast Cancer Brain Metastasis Groups - CancerNetwork
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Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations - Wiley Online Library
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SPANXB1 drives brain metastasis in breast cancer via MMP1 regulation: potential therapeutic insights with metformin - Nature
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Analysis of Anticoagulants in Patients with Brain Metastases - Cleveland Clinic
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Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non-Small Cell Lung Cancer Brain Metastasis - Wiley
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Breast cancer brain metastasis: bridging biological mechanisms to therapeutic innovations - EurekAlert!
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Leading group in brain metastasis research predicts mid-term advances that will improve patients’ lives - Centro Nacional de Investigaciones Oncológicas - CNIO
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A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis - Science | AAAS
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Silent Threat: Delayed Brain Metastasis After Successful Ovarian Cancer Therapy - Rupa - 2025 - Clinical Case Reports - Wiley Online Library
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Direct-Acting Oral Anticoagulants Safe for Patients with Brain Metastasis - Cleveland Clinic
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Trastuzumab deruxtecan shows positive results in rare breast cancer with brain metastasis - EurekAlert!
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Ischemic stroke of undetermined source as a priming event for brain metastasis: a case report and systematic literature review - Frontiers
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Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI - Nature
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Stephen V Liu: METIS Trial Shows TTFields Delay Brain Metastasis Progression in NSCLC - Oncodaily
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The prognostic importance of neuronatin positivity as immunohistochemical in patients with lung adenocarcinoma in the development of brain metastasis | Scientific Reports - Nature
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Pathological complete response to conversion therapy for lung adenocarcinoma with brain metastasis: a case report - Frontiers
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Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways - Frontiers
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Exploration of patient plasma exosomes as biomarkers for predicting lung cancer brain metastasis - Frontiers
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Concurrent systemic treatment during stereotactic radiosurgery for breast cancer brain metastasis: analysis of survival outcomes and propensity score matching analysis | Mauro | Reports of Practical Oncology and Radiotherapy - Via Medica Journals
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Silent Threat: Delayed Brain Metastasis After Successful Ovarian Cancer Therapy - Rupa - 2025 - Clinical Case Reports - Wiley Online Library
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How Cancer "Hides" From the Brain's Immune Cells as It Metastasizes - Technology Networks
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Alireza Mansouri: Predicting Brain Metastasis Development in NSCLC with Innovative Nomograms - Oncodaily
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Bridging the Gap: First Clinical Experience With Linear Accelerator (LINAC) Radiosurgery Using Automated HyperARC for Brain Metastasis in a Low-Resource Setting in Pakistan - Cureus
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HER3-DXd in Active Brain Metastases: Early Signals of Intracranial Activity in HER2-Positive MBC - Docwire News
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SABCS 2025: REVEAL GENOMICS Presents Major Advance in Predicting Brain Metastasis in HER2+ Breast Cancer - Business Wire
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How Breast Cancer Spreads to the Brain - Technology Networks
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Blood-brain barrier alterations as an initiator of brain metastasis from lung cancer: a new take on an old story - Nature
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Enhancing NSCLC Brain Metastasis Treatment With MR-Guided Ultrasound: Manmeet Ahluwalia, MD, MBA, FASCO - AJMC
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Development of a prognostic risk stratification model for HER2-positive breast cancer brain metastasis and its implications in guiding treatment decisions - Nature
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New AI Methods Advance Diagnosis After Brain Metastasis Treatment - Duke University School of Medicine
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Clinical Insights on the Next Treatment Approach for Metastatic HER2+ Breast Cancer with Brain Metastasis - OncLive
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Brain structural alterations and cognitive dysfunction in lung cancer patients without brain metastasis - Nature
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Wins for Cabozantinib in Kidney Cancer Brain Mets, Aggressive Disease Subtype - MedPage Today
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Case Report: Pathological complete response yet early brain relapse in HER2-positive breast cancer: a case-based review - Frontiers
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GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway - Nature
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Accendatech's Phase 3 Trial of ACT001, an Oral Compound with Novel MoA, Begins Enrolling Patients with Small Cell Lung Cancer with Brain Metastasis in a Highly Competitive Research Field - Business Wire
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A Rare Case of Brain Metastasis of Gastric Neuroendocrine Carcinoma - Cureus
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“New Hope” for Melanoma Patients With CNS Metastases - Oncology News Central
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Case 1: Isolated Brain Relapse in HER2-Positive Breast Cancer - The ASCO Post
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Non-invasive fluorescence imaging of breast cancer metastasis to the brain in an orthotopic nude-mouse model - SelectScience
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Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy - Nature
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Breast Cancer Brain Metastasis: A Comprehensive Review - ASCO Publications
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Prediction of brain metastasis development with DNA methylation signatures - Nature
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Patient With Metastatic NSCLC and Brain Metastasis - The ASCO Post
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Progress in personalized immunotherapy for patients with brain metastasis - Nature
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The epigenetic landscape of brain metastasis - Oncogene - Nature
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A Genetic Screen Identifies a New Master Regulator of Brain Metastasis - Yale School of Medicine
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Whole brain radiotherapy and simultaneous integrated boost: is it still a viable treatment for multiple brain metastases in the era of SRS? | Yıldırım | Reports of Practical Oncology and Radiotherapy - Via Medica Journals
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Role of GPX3+ astrocytes in breast cancer brain metastasis activated by circulating tumor cell exosomes - Nature
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Symptomatic Prostate-Specific Membrane Antigen PET–Positive Radionecrosis After Multimodality Brain Metastasis–Directed Treatment Including [177Lu]Lu-PSMA-617 - Journal of Nuclear Medicine
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UTD1 Receives FDA Orphan Drug Designation in Breast Cancer Brain Metastasis - OncLive
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UNMC researchers identify key protein in breast cancer brain metastasis - University of Nebraska Medical Center
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Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 - Nature
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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis - Nature
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Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis - Nature
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An unexpected corridor to brain metastasis - Science | AAAS
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Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity - Science | AAAS
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Metabolic Reprogramming Underlying Brain Metastasis of Breast Cancer - Frontiers
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Immunotherapy Confers Survival Benefit in NSCLC Patients With Brain Metastasis - Cancer Therapy Advisor
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Challenges in Treating Brain Metastasis in HER2-Positive Breast Cancer - Targeted Oncology
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Bria-IMT Plus Immunotherapy Shows Early Promise in Breast Cancer Brain Metastasis - OncLive
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Machine learning-based prediction model for brain metastasis in patients with extensive-stage small cell lung cancer - Nature
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An in vivo screen identifies NAT10 as a master regulator of brain metastasis - Science | AAAS
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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment - Nature
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Scientists Discover a Preventative Approach for Brain Metastasis - Inside Precision Medicine
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Cancer Discovery. CNIO researchers propose a new treatment for brain metastasis based on immunotherapy - Centro Nacional de Investigaciones Oncológicas - CNIO
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Cancer Cells Hijack the Neuron-Glia Connection for Brain Metastasis - the-scientist.com
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SRS With Immunotherapy Extends Survival in RCC With Brain Metastasis - Targeted Oncology
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Incidence and impact of brain metastasis in patients with hereditary BRCA1 or BRCA2 mutated invasive breast cancer - Nature
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Computing brain metastasis impact - Nature
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A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information - Nature
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Improving Outcomes in RCC Brain Metastasis With SRS and Immunotherapy - Targeted Oncology
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Estimating the risk of brain metastasis for patients newly diagnosed with cancer - Nature
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Feeding latent brain metastasis - Nature
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Breast cancer brain metastasis: insight into molecular mechanisms and therapeutic strategies - Nature
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Systemic Treatment a Major Factor Impacting Survival of Patients with Breast Cancer with Brain Metastasis - Cleveland Clinic
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Brain metastasis, EGFR mutation subtype and generation of EGFR-TKI jointly influence the treatment outcome of patient with EGFR -mutant NSCLC - Nature
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Analysis of risk factors and prognostic factors of brain metastasis in gastric cancer: a surveillance, epidemiology and end-results database study - Nature
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Editorial: Advances of brain metastasis in breast cancer - Frontiers
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.