Why is "Bromodomain" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-15 13:12:03
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Bromodomain entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-15 and was most recently seen on 2026-04-15.
Wikipedia Overview
A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones. Bromodomains, as the "readers" of lysine acetylation, are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes. Their affinity is higher for regions where multiple acetylation sites exist in proximity. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices each separated by loop regions of variable lengths that form a hydrophobic pocket that recognizes the acetyl lysine.
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Trending Topic Today
Search Interest Perspective
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Bromodomain and extra-terminal protein inhibitors modulate natural killer cell function and differentiation - Nature
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Bromodomain and extra-terminal proteins in solid tumors: regulators of immune microenvironment and emerging therapeutic targets - Frontiers
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Bromodomain-containing 4 as a therapeutic target in inflammatory bowel diseases and colorectal cancer - Frontiers
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Bromodomain-containing proteins interact with a non-canonical RNA polymerase II kinase to maintain gene expression upon heat stress - Nature
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An apicomplexan bromodomain protein, TgBDP1, associates with diverse epigenetic factors to regulate essential transcriptional processes in Toxoplasma gondii - ASM Journals
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Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention - PNAS
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Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens - PNAS
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BRPF1 in cancer epigenetics: a key regulator of histone acetylation and a promising therapeutic target - Nature
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Genome-wide analysis of bromodomain gene family in Arabidopsis and rice - Frontiers
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Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections - PNAS
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Bromodomain factor 5 is an essential regulator of transcription in Leishmania - Nature
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Discovery and characterization of bromodomain 2–specific inhibitors of BRDT - PNAS
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Bromodomain biology and drug discovery - Nature
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Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy - Nature
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Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity - Nature
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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia - Nature
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Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production - Nature
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BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia - Nature
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Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer - Nature
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Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4 - Nature
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Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival - Nature
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A chemical toolbox for the study of bromodomains and epigenetic signaling - Nature
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Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming - Nature
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Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo - Nature
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Selective BET bromodomain inhibition as an antifungal therapeutic strategy - Nature
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Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer - Nature
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The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair - Nature
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Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis - Nature
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Functional networks of the human bromodomain-containing proteins - Frontiers
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Bromodomain proteins: protectors against endogenous DNA damage and facilitators of genome integrity - Nature
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Lysine-Targeting, Covalent Inhibitors of Bromodomain BD1 of BET Proteins in Live Cells and Animals - Wiley Online Library
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Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics - Nature
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Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock - Nature
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Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer - Nature
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The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis - PNAS
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Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition - Nature
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A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT - Nature
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BET bromodomain inhibitors regulate keratinocyte plasticity - Nature
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Bromodomain-containing protein 9 promotes the growth and metastasis of human hepatocellular carcinoma by activating the TUFT1/AKT pathway - Nature
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The Pseudo‐Natural Product Tafbromin Selectively Targets the TAF1 Bromodomain 2 - Wiley Online Library
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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer - Nature
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Bromodomain and extraterminal protein inhibitor JQ1 induces maturation arrest and disrupts the cytoplasmic organization in mouse oocytes under in vitro conditions - Nature
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Discovery of BET specific bromodomain inhibitors with a novel scaffold - ScienceDirect.com
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Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles - Nature
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The bromodomain: a chromatin-targeting module? - Nature
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BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis - Nature
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Bromodomains: a new target class for drug development - Nature
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Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer - Nature
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Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1 - Nature
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas - Nature
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A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes - Science | AAAS
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Chemical synthesis of the ATAD2 bromodomain - PNAS
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Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening - Nature
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Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases - Wiley Online Library
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Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma - Nature
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Vyne's lead BET inhibitor fails phase 2 vitiligo trial, sinking stock - Fierce Biotech
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Why a promising breast cancer drug doesn’t work—and how to improve it - The Rockefeller University
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Essential Bromodomain TcBDF2 as a Drug Target against Chagas Disease - ACS Publications
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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling - Nature
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Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells - Nature
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The bromodomain inhibitor JQ1 up-regulates the long non-coding RNA MALAT1 in cultured human hepatic carcinoma cells - Nature
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Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer - Nature
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Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS -mutated NSCLC to pro-apoptotic agents - Nature
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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology - Nature
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Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay - Nature
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Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages | Scientific Reports - Nature
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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma - Nature
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BET bromodomain inhibitor JQ1 preferentially suppresses EBV-positive nasopharyngeal carcinoma cells partially through repressing c-Myc - Nature
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USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy - Nature
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The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response - Nature
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BET Bromodomain Suppression Inhibits VEGF-induced Angiogenesis and Vascular Permeability by Blocking VEGFR2-mediated Activation of PAK1 and eNOS - Nature
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Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2 - Nature
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Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells - Nature
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DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes - Nature
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Targeting bromodomains: epigenetic readers of lysine acetylation - Nature
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Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study - Nature
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Bromodomain 4 activation predicts breast cancer survival - PNAS
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Histone post-translational modifications — cause and consequence of genome function - Nature
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Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity - PNAS
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Bromodomain and extra-terminal inhibitors emerge as potential therapeutic avenues for gastrointestinal cancers - Baishideng Publishing Group
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A faster, less expensive approach identifies highly specific anti-cancer compounds - Baylor College of Medicine Blog Network -
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BET bromodomain inhibitors synergize with ATR inhibitors in melanoma - Nature
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Structure and acetyl-lysine recognition of the bromodomain - Nature
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Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β–dependent mechanisms - PNAS
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An apicomplexan bromodomain protein, TgBDP1, associates with diverse epigenetic factors to regulate essential transcriptional processes in Toxoplasma gondii - ASM Journals
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Discovery of a hidden transient state in all bromodomain families - PNAS
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Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins - Nature
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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain - PNAS
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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma - PNAS
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Study Discovers Novel Region for BRD4 Transcription and Potential Therapeutic Target - Northwestern University
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Correction to: BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia - Nature
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Targeting non-bromodomain chromatin readers - Nature
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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain - Nature
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Widening the window of bromodomain inhibition - Nature
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Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain - Wiley Online Library
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Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4-MYC oncogenic axis in multiple myeloma - Wiley Online Library
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Pan-cancer analyses of bromodomain containing 9 as a novel therapeutic target reveals its diagnostic, prognostic potential and biological mechanism in human tumours - Wiley Online Library
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Inhibition of the TRIM24 bromodomain reactivates latent HIV-1 - Nature
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Structure of the histone chaperone CIA/ASF1–double bromodomain complex linking histone modifications and site-specific histone eviction - PNAS
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Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.