Why is "CYP2A6" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-03-31 08:59:01
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Cytochrome P450 2A6 is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. CYP2A6 is the primary enzyme responsible for the oxidation of nicotine and cotinine. It is also involved in the metabolism of several pharmaceuticals, carcinogens, and a number of coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body that appreciably catalyzes the 7-hydroxylation of coumarin, such that the formation of the product of this reaction, 7-hydroxycoumarin, is used as a probe for CYP2A6 activity.
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Search Interest Perspective
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CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway - Nature
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Curcumin Successfully Inhibited the Computationally Identified CYP2A6 Enzyme-Mediated Bioactivation of Aflatoxin B1 in Arbor Acres broiler - Frontiers
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Genotyping, characterization, and imputation of known and novel CYP2A6 structural variants using SNP array data - Nature
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Dr. Lu Publishes on Nicotine and Alcohol Interaction in the Liver - East Tennessee State University
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WSU Spokane researchers develop potential drugs to help curb smoking - WSU Insider
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Study finds vaping has long-term effect on the heart for adolescent males but not females - Medical Xpress
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Newly-devised molecule might help people quit smoking by blocking nicotine break-down - ZME Science
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Fine-mapping the CYP2A6 regional association with nicotine metabolism among African American smokers - Nature
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Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer - Frontiers
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CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation - Nature
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Effect of very low nicotine content cigarettes on smoking behavior in Chinese smokers with genotype-stratified nicotine metabolism rates - Frontiers
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Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension - Nature
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Sequence variants at CHRNB3 CHRNA6 and CYP2A6 affect smoking behavior - Nature
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Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy - Nature
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Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme—an in silico approach - Nature
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Nicotine self-administration with menthol and audiovisual cue facilitates differential packaging of CYP2A6 and cytokines/chemokines in rat plasma extracellular vesicles - Nature
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Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes - Nature
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CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele - Nature
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Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans - Nature
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Characterisation of pharmacogenomic variation in the Shetland and Orkney Isles in Scotland - Nature
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Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review - Frontiers
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Personalized medicine to help smokers quit - American Psychological Association (APA)
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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation - Nature
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WSU Spokane Researchers Develop Potential Drugs to Help Curb Smoking - Lab Manager
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Polymorphisms of ADME-related genes and their implications for drug safety and efficacy in Amazonian Amerindians - Nature
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Health | Genetic link to smoking addiction - BBC
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Accurate transcriptome assembly by Nanopore RNA sequencing reveals novel functional transcripts in hepatocellular carcinoma - Wiley Online Library
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Friends connect on a genetic level - Nature
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Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation - Nature
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Catalog of 680 variations among eight cytochrome P450 ( CYP ) genes, nine esterase genes, and two other genes in the Japanese population - Nature
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Mechanism-based medication development for the treatment of nicotine dependence | Acta Pharmacologica Sinica - Nature
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‘Java genes’ explain why coffee doesn’t work for some people - ZME Science
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Beware Interactions Between Cinnamon and Medications - The People's Pharmacy
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Genetic factors of esophageal cancer commonly found among Japanese population discovered - 大阪大学
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Your genes help you pick friends | India News - Hindustan Times
Why This Topic Is Trending
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