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The Casa Pazzi Madonna is a fresco fragment by Andrea del Castagno, created in 1443, originally the altarpiece of the chapel of Santa Brigida at the castello del Trebbio in the Pontassieve district, then owned by Andrea de' Pazzi, hence the painting's name. Removed from the wall in the 19th century it is now in the Contini Bonacossi collection within the Uffizi in Florence.
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