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In simple words, the cistrome refers to a collection of regulatory elements of a set of genes, including transcription factor binding sites and histone modifications. More specifically, "the set of cis-acting targets of a trans-acting factor on a genome-wide scale, also known as the in vivo genome-wide location of transcription factor binding sites or histone modifications". The term cistrome is a portmanteau of cistr + ome. The term cistrome was coined by investigators at the Dana–Farber Cancer Institute and Harvard Medical School.
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