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The first large-scale human trial of the birth control pill was unethically conducted by Gregory Pincus and John Rock in 1955 in Puerto Rico. Before the drug was approved as safe in the mainland U.S., many poor and uneducated Puerto Rican women were used as guinea pigs by Gregory and John. These trials are a major component in the history of the development of female oral contraceptives, occurring in between initial small trial testing on the east coast and the release of the drug for public consumption. The trials are controversial because the Puerto Rican women were uninformed of the potential health and safety risks of the drug. There was a large amount of criticism coming from feminist circles surrounding the trial.
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