Why is "Daf-16" trending?
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- Date: 2026-03-29 04:07:23
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Wikipedia Overview
DAF-16 is the sole ortholog of the FOXO family of transcription factors in the nematode Caenorhabditis elegans. It is responsible for activating genes involved in longevity, lipogenesis, heat shock survival and oxidative stress responses. It also protects C.elegans during food deprivation, causing it to transform into a hibernation - like state, known as a Dauer. DAF-16 is notable for being the primary transcription factor required for the profound lifespan extension observed upon mutation of the insulin-like receptor DAF-2. The gene has played a large role in research into longevity and the insulin signalling pathway as it is located in C. elegans, a successful ageing model organism.
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Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins - Nature
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Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth - Nature
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DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans - Nature
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DAF-16/FOXO Transcription Factor in Aging and Longevity - Frontiers
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The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development - Nature
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DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism - Science | AAAS
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Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans - Nature
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Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction - Nature
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DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes - Nature
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DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity - Nature
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DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells - Nature
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DAF-21/Hsp90 is required for C elegans longevity by ensuring DAF-16/FOXO isoform A function - Nature
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Jujubae Fructus extract prolongs lifespan and improves stress tolerance in Caenorhabditis elegans dependent on DAF-16/SOD-3 - Nature
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The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68 - Nature
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LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling - Nature
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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling - Nature
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A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans | Scientific Reports - Nature
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Interplay of neuronal and non-neuronal genes regulates intestinal DAF-16-mediated immune response during Fusarium infection of Caenorhabditis elegans - Nature
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Non-autonomous DAF-16/FOXO activity antagonizes age-related loss of C. elegans germline stem/progenitor cells - Nature
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Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost - Nature
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A new DAF-16 isoform regulates longevity - Nature
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Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease - Frontiers
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Lifespan-regulating genes in C. elegans - Nature
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alleviates aging by activating daf-18 Pten ) and independent of daf-16 - Nature
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Selaginella Extracts Extend Lifespan and Mitigate Oxidative Stress in Caenorhabditis elegans - Frontiers
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Function of RSKS-1-AAK-2-DAF-16 signaling cascade in enhancing toxicity of multi-walled carbon nanotubes can be suppressed by mir-259 activation in Caenorhabditis elegans - Nature
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Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans - PNAS
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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans - Nature
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Alpiniae oxyphylla fructus extract promotes longevity and stress resistance of C. elegans via DAF-16 and SKN-1 - Frontiers
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Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes - Science | AAAS
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Intestinal Insulin Signaling Encodes Two Different Molecular Mechanisms for the Shortened Longevity Induced by Graphene Oxide in Caenorhabditis elegans - Nature
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DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage - Nature
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Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity - Nature
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Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway - Frontiers
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SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans - Nature
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Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans - Nature
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Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans - Nature
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Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling - Nature
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Salmonella enterica serovar Paratyphi A-induced immune response in Caenorhabditis elegans depends on MAPK pathways and DAF-16 - Frontiers
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Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions - PNAS
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A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling - Nature
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DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity - Nature
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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans - Nature
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Lactobacillus paracasei subsp. paracasei 2004 improves health and lifespan in Caenorhabditis elegans - Nature
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PQM-1 controls hypoxic survival via regulation of lipid metabolism - Nature
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Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation - Nature
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Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans - Nature
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MiDaf16 like and MiSkn1-like gene families are reliable targets to develop biotechnological tools for the control and management of Meloidogyne incognita - Nature
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MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans - Nature
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ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans - Nature
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Endosomal trafficking protein TBC-2 modulates stress resistance and lifespan through DAF-16-dependent and independent mechanisms - Wiley Online Library
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Neurosecretory control of aging in Caenorhabditis elegans - PNAS
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The C. elegans miR-235 regulates the toxicity of graphene oxide via targeting the nuclear hormone receptor DAF-12 in the intestine - Nature
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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling - PNAS
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Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans - PNAS
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MONITTR allows real-time imaging of transcription and endogenous proteins in C. elegans - Rockefeller University Press
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DAF-2c signaling promotes taste avoidance after starvation in Caenorhabditis elegans by controlling distinct phospholipase C isozymes - Nature
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Phloretic acid requires the insulin/IGF-1 pathway and autophagy to enhance stress resistance and extend the lifespan of Caenorhabditis elegans - Frontiers
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Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging - PNAS
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An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress - Nature
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Elucidating the Mechanism of Weissella -dependent Lifespan Extension in Caenorhabditis elegans - Nature
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Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans | Scientific Reports - Nature
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Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance - Nature
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Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans - Journal of Neuroscience
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Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans - Nature
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Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans - Nature
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Screening for cold tolerance genes in C. elegans , whose expressions are affected by anticancer drugs camptothecin and leptomycin B - Nature
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The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans - Nature
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Age-dependent heat shock hormesis to HSF-1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans - Wiley Online Library
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RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2 /insulin/IGF-1 mutant C. elegans - Nature
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Aging-US: Sulforaphane promotes C. elegans longevity and healthspan - EurekAlert!
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Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways - Nature
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Profile of Gary Ruvkun - PNAS
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Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. elegans - Science | AAAS
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Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response - Nature
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Apigenin glycosides from green pepper enhance longevity and stress resistance in Caenorhabditis elegans - sciencedirect.com
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Intestinal long non-coding RNAs in response to simulated microgravity stress in Caenorhabditis elegans - Nature
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Evolution of germ-line signals that regulate growth and aging in nematodes - PNAS
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Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system | Scientific Reports - Nature
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Visible light reduces C. elegans longevity - Nature
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Fat Metabolism Regulates Satiety Behavior in C. elegans - Nature
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Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans - Frontiers
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Mechanisms of aging-related proteinopathies in Caenorhabditis elegans - Nature
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Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans - Nature
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Neuro-intestinal acetylcholine signalling regulates the mitochondrial stress response in Caenorhabditis elegans - Nature
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Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 - PNAS
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Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans - Nature
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A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans - Nature
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Cells use Morse code-like rhythms to coordinate growth - Phys.org
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Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification - PNAS
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Metabotropic GABA signalling modulates longevity in C. elegans - Nature
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Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity - PNAS
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Mitochondrial Function Is Required for Secretion of DAF-28/Insulin in C. elegans - PLOS
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Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans - Nature
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Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans - Nature
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Antiamyloid β toxicity effect of genistein via activation of DAF-16 and HSP-16.2 signal pathways in Caenorhabditis elegans - Wiley Online Library
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Role of phospholipase D in the lifespan of Caenorhabditis elegans - Nature
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Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways - Nature
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1-Mesityl-3-(3-Sulfonatopropyl) Imidazolium Protects Against Oxidative Stress and Delays Proteotoxicity in C. elegans - Frontiers
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Sulforaphane prolongs lifespan and healthspan of C. elegans through insulin/IGF-1 signaling - News-Medical
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