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- Date: 2026-04-11 00:31:47
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Wikipedia Overview
In organic chemistry, the Diels–Alder reaction is a chemical reaction between a conjugated diene and a substituted alkene, commonly termed the dienophile, to form a substituted cyclohexene derivative. It is the prototypical pericyclic reaction with a concerted mechanism; specifically, it is a thermally-allowed [4+2] cycloaddition with Woodward–Hoffmann symbol [π4s + π2s].
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Formal Diels–Alder reaction of saturated carboxylic acids via C–H activation - Nature
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Regioisomeric Tuning of Intermolecular Diels-Alder Reaction by Electrostatic Field-Dipole Interaction - Wiley
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Diels-Alder reaction affords circumpyrene tetracarboxydiimide with excited state intramolecular charge transfer character | Communications Chemistry - Nature
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The Diels–Alder Reaction as a Mechanistic Probe for Vibrational Strong Coupling - Wiley Online Library
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Diels–Alder Reaction Advances via C–H Activation - Bioengineer.org
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Magnetic Induction Heating Enables On-Demand Drug Release via Diels–Alder Polymeric Nanocarriers - ACS Publications
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Electric field–catalyzed single-molecule Diels-Alder reaction dynamics - Science | AAAS
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Development of a Vinylated Cyclic Allene: A Fleeting Strained Diene for the Diels–Alder Reaction - Wiley Online Library
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Lewis Acid-Catalyzed Domino Inverse Electron-Demand Diels–Alder/Thermal Ring Expansion Reaction for the Synthesis of Arene-Annulated Eight-Membered Nitrogen Heterocycles | Organic Letters - ACS Publications
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An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone - Nature
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Real-Time Visualisation of Reaction Kinetics and Dynamics: Single-Molecule Insights into the Iminium-Catalysed Diels–Alder Reaction - Wiley Online Library
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Controlling cyclodextrin host-guest complexation in water with dynamic pericyclic chemistry - Nature
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Inverse‐Electron‐Demand Diels–Alder Reaction Involving Indole Scaffold and Its Derivatives - Wiley Online Library
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A polyheteroatomic Diels–Alderase - Nature
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Inverse-Electron-Demand Diels–Alder Reaction of Tropone with Graphene Supported on Cu(111) - Wiley Online Library
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Self-assembly using a retro Diels-Alder reaction - Nature
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Regioselective Synthesis of Carbazoles via Chemodivergent Cascade Intramolecular [4 + 2] Annulation - Wiley
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Topochemical synthesis of chiroptical materials through charge-transfer/Diels–Alder cascade reaction - Nature
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Evolution of the Diels–Alder Reaction Mechanism since the 1930s: Woodward, Houk with Woodward, and the Influence of Computational Chemistry on Understanding Cycloadditions - Wiley Online Library
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Exo -selective intermolecular Diels–Alder reaction by PyrI4 and AbnU on non-natural substrates - Nature
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Inducing high exo selectivity in Diels–Alder reaction by dimethylborane substituent: a DFT study - Nature
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Diels-Alder reaction directly observed under the microscope - Chemistry World
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Asymmetric hetero-Diels–Alder reaction catalyzed by dirhodium(II) carboxamidates - PNAS
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An on‐surface Diels–Alder reaction - Castro‐Esteban - 2021 - Angewandte Chemie International Edition - Wiley Online Library
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Catalytic asymmetric oxa-Diels–Alder reaction of acroleins with simple alkenes - Nature
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Acceleration of Diels-Alder reactions by mechanical distortion - Science | AAAS
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Industrial Applications of the Diels–Alder Reaction - Funel - 2013 - Angewandte Chemie International Edition - Wiley Online Library
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Water microdroplet chemistry enables catalyst-free Diels–Alder reaction - Chemistry World
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Unusual KIE and dynamics effects in the Fe-catalyzed hetero-Diels-Alder reaction of unactivated aldehydes and dienes - Nature
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An enantioselective ambimodal cross-Diels–Alder reaction and applications in synthesis - Nature
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Electrostatic catalysis of a Diels–Alder reaction - Nature
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Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells - Nature
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The hexadehydro-Diels–Alder reaction - Nature
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(M=Lu, Sc): Reactivity and Reversibility Enable Chemical Separation of Metallofullerenes - Wiley Online Library
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Total Synthesis of (−)-Lamellodysidine A via an Intramolecular Diels–Alder Reaction - ACS Publications
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Catalytic Asymmetric Aza‐Diels–Alder Reaction of Ketimines and Unactivated Dienes - Wiley Online Library
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Pushing the ball uphill: energetically unfavourable Diels-Alder reaction driven by chemical fuel - Chemistry World
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Catalyst closes a gap in hetero Diels-Alder reaction - C&EN
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Enantioselective Synthesis of Atropisomeric Tri-Axis Naphthalenes via Diels–Alder Reaction and Dehydrative Aromatization of Isobenzofurans - Wiley Online Library
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Structural and solvent control over activation parameters for a pair of retro Diels-Alder reactions - Nature
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Self‐Accelerating Diels–Alder Reaction for Preparing Polymers of Intrinsic Microporosity - Wiley Online Library
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Houk group research featured in Nature Chemistry - UCLA – Chemistry and Biochemistry
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Quinones as Dienophiles in the Diels–Alder Reaction: History and Applications in Total Synthesis - Wiley Online Library
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Diels–Alder reactions and electrophilic substitutions with atypical regioselectivity enable functionalization of terminal rings of anthracene - Nature
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C( alkyl )–C( vinyl ) bond cleavage enabled by Retro-Pallada-Diels-Alder reaction - Nature
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Synthesis of a Bicyclo[2.2.1]heptane Skeleton with Two Oxy-Functionalized Bridgehead Carbons via the Diels–Alder Reaction - ACS Publications
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First natural Diels–Alder enzyme discovered in mulberry tree - Chemistry World
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Total Synthesis of Lugdunomycin via Sequential Photoinduced Spiroketalization and Isobenzofuran Diels–Alder Reactions - Wiley Online Library
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Diels–Alder study casts doubt on innate endo-selectivity - Chemistry World
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Hexadehydro Diels–Alder/Alkynyliodanation Cascade: A Highly Regioselective Entry to Polycyclic Aromatics - ACS Publications
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Stereoselective Sequential Diels–Alder Reactions on a Cyclic Furan Trimer for the Construction of an Asymmetric Scaffold | Organic Letters - ACS Publications
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Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody - Journal of Nuclear Medicine
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The Asymmetric Hetero‐Diels–Alder Reaction in the Syntheses of Biologically Relevant Compounds - Wiley Online Library
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Formation of 6-Azaindoles by Intramolecular Diels–Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A - ACS Publications
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Three-component diels-alder reaction through palladium carbene migratory insertion enabled dearomative C(sp - Nature
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MEDT analysis of mechanism and selectivities in non-catalyzed and lewis acid-catalyzed diels–alder reactions between R-carvone and isoprene - Nature
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How Lewis Acids Catalyze Diels–Alder Reactions - Vermeeren - 2020 - Angewandte Chemie International Edition - Wiley Online Library
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Copper-Catalyzed Enantioselective Dehydro-Diels–Alder Reaction: Atom-Economical Synthesis of Axially Chiral Carbazoles - Wiley Online Library
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Molecular cage seizes control in tetradehydro Diels–Alder reaction - Chemistry World
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The evolutionary origin of naturally occurring intermolecular Diels-Alderases from Morus alba - Nature
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Antiaromaticity Gain Activates Tropone and Nonbenzenoid Aromatics as Normal-Electron-Demand Diels–Alder Dienes - ACS Publications
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-THC) and Their cis Analogs Using an Enantioselective Organocatalyzed Diels–Alder Reaction - ACS Publications
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Highly Stereoselective Diels–Alder Reactions Catalyzed by Diboronate Complexes** - Wiley Online Library
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Unconventional exo selectivity in thermal normal-electron-demand Diels–Alder reactions - Nature
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Computational study on the catalytic control of endo exo Diels-Alder reactions by cavity quantum vacuum fluctuations - Nature
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Engineered Diels-Alder enzyme is fast and selective - C&EN
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Turbo-charged Diels-Alder reaction - Chemistry World
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Catalytic Asymmetric Aza‐Diels–Alder Reaction of Ketimines and Unactivated Dienes - Wiley Online Library
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The Houk and Tang groups discover an organocatalytic Diels-Alderase in Nature - UCLA – Chemistry and Biochemistry
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Cerium(III) immobilized on the functionalized halloysite as a highly efficient catalyst for aza-Diels–Alder reaction - Nature
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Large Molecular Rotation in Crystal Changes the Course of a Topochemical Diels–Alder Reaction from a Predicted Polymerization to an Unexpected Intramolecular Cyclization - Wiley Online Library
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A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions - Nature
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Radical Cation Diels–Alder Reactions by TiO2 Photocatalysis - ACS Publications
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Gold-Catalyzed Cycloisomerization/1,5-H Migration/Diels–Alder Reaction Cascade: Synthesis of Complex Nitrogen-Containing Heterocycles | Organic Letters - ACS Publications
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Recent advances of Diels–Alderases involved in natural product biosynthesis - Nature
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Full article: Diels-Alder reactions in the presence of a minimal amount of water - Taylor & Francis Online
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Organocatalytic Enantioselective Diels–Alder Reaction of 2-Trifluoroacetamido-1,3-dienes with α,β-Unsaturated Ketones - Wiley Online Library
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N‐Heterocyclic Carbene Catalyzed Photoenolization/Diels–Alder Reaction of Acid Fluorides - Wiley Online Library
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Diels–Alder polymerization: a versatile synthetic method toward functional polyphenylenes, ladder polymers and graphene nanoribbons - Nature
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Highly Stereoselective Diels–Alder-Based Strategy for the Synthesis of 3-epi-Formicin A and 1-epi-Formicin B - ACS Publications
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Two-Way Catalysis in a Diels–Alder Reaction Limits Inhibition Induced by an External Electric Field - Wiley Online Library
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Photoinduced formal [4 + 2] cycloaddition of two electron-deficient olefins and its application to the synthesis of lucidumone - Nature
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The Hexadehydro‐Diels–Alder Reaction: A New Chapter in Aryne Chemistry - Wiley Online Library
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When molecules just need a push in the right direction - C&EN
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TEMPO-Mediated Aza-Diels–Alder Reaction: Synthesis of Tetrahydropyridazines Using Ketohydrazones and Olefins - ACS Publications
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Zapping Diels-Alder reactions - C&EN
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A Diels–Alder super diene breaking benzene into C - Nature
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Doing the impossible: enzyme-catalyzed Diels-Alder reaction - Asia Research News |
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Synthesis of Robust MOFs@COFs Porous Hybrid Materials via an Aza-Diels–Alder Reaction: Towards High-Performance Supercapacitor Materials - Wiley Online Library
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Temporal Control of Efficient In Vivo Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels–Alder Reaction - ACS Publications
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Retro-Diels–Alder study links solvent viscosity to reaction rate under microwave heating - Chemistry World
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A multi-substrate screening approach for the identification of a broadly applicable Diels–Alder catalyst - Nature
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Insight into a natural Diels–Alder reaction from the structure of macrophomate synthase - Nature
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Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditions - Nature
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Furan-containing polymeric Materials: Harnessing the Diels-Alder chemistry for biomedical applications - ScienceDirect.com
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A thorough understanding of the Diels–Alder reaction of 1,3‐butadiene and ethylene - Wiley Online Library
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Theoretical study of cyano‐promoted intramolecular aza‐Diels–Alder reaction - Wiley Online Library
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First reaction on carbon nanobelts creates largest ever iptycene - Chemistry World
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A Dehydrogenative Diels–Alder/Aromatization Sequence to Access 6/6/6/6/5 Pentacyclic Steroids: Their Anti-inflammatory Activities | Organic Letters - ACS Publications
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Diels-Alder reaction rate in the solid state and the evidence of the location of molecular complexes between the reagents on the reaction pathway - Wiley Online Library
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