Why is "Enhancer (genetics)" trending?

Search Interest Perspective

• Temporal constraints on enhancer usage shape the regulation of limb gene transcription - Nature
• A Suite of Enhancer AAVs Support Targeted Gene Therapy for Brain Disease - Genetic Engineering and Biotechnology News
• JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation - Nature
• Promoters and enhancers: Tool catches gene-controlling DNA sequences doing each other's jobs - Phys.org
• Enhancers are genes that express organizational RNAs - Frontiers
• Relating enhancer genetic variation across mammals to complex phenotypes using machine learning - Science | AAAS
• Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature
• Is enhancer-driven gene regulation all wrapped up? - Nature
• Genome synteny reveals hidden enhancer conservation - Nature
• Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles - Nature
• Context transcription factors establish cooperative environments and mediate enhancer communication - Nature
• Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions - Nature
• Increased enhancer–promoter interactions during developmental enhancer activation in mammals - Nature
• Enhancer–promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation - Nature
• Dynamic interplay between enhancer–promoter topology and gene activity - Nature
• Genetic coupling of enhancer activity and connectivity in gene expression control - Nature
• Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs - Nature
• Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells - Nature
• Large-scale discovery of potent, compact and erythroid specific enhancers for gene therapy vectors - Nature
• Dynamic interplay between non-coding enhancer transcription and gene activity in development - Nature
• Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk - Nature
• Enhancer RNA transcription pinpoints functional genetic variants linked to asthma - Nature
• RNA polymerase II dynamics shape enhancer–promoter interactions - Nature
• Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness - Nature
• Genome-wide enhancer maps link risk variants to disease genes - Nature
• Enhancer–promoter specificity in gene transcription: molecular mechanisms and disease associations - Nature
• Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis - Nature
• Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis - Nature
• A principled strategy for mapping enhancers to genes - Nature
• Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes - Nature
• Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations - Nature
• Long-range enhancer–promoter contacts in gene expression control - Nature
• Single-gene imaging links genome topology, promoter–enhancer communication and transcription control - Nature
• SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks - Nature
• Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping - Nature
• Enhancer–promoter contact formation requires RNAPII and antagonizes loop extrusion - Nature
• Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation - Nature
• Gene Enhancers Are Important Despite Apparent Redundancy - Berkeley Lab News Center (.gov)
• Global discovery of lupus genetic risk variant allelic enhancer activity - Nature
• UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs - Nature
• MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation - Nature
• The effect of genetic variation on promoter usage and enhancer activity - Nature
• Enhancers assemble! - Nature
• Sex Determination for Males Hinges on Gene Enhancer - Genetic Engineering and Biotechnology News
• PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma - Nature
• Genome-wide analysis of enhancer RNA in gene regulation across 12 mouse tissues - Nature
• Transcription factors: from enhancer binding to developmental control - Nature