Why is "Epistatic" trending?

Search Interest Perspective

• How population subsampling to concentrate selection effects can help to find epistatic interactions of transmission ratio distortion - Nature
• Structural and epistatic regulatory variants cause hallmark white spotting in cattle - Science | AAAS
• Behind the Science: Epistasis, the sly genetic tag team behind some heart disease - Stanford Medicine
• Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection - PNAS
• Epistatic contributions to human traits via transcription factor mechanisms - medRxiv
• Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? - ASM Journals
• A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction effects - Nature
• A new genetic architecture for PHS resistance in rice: deciphering the epistatic interactions of three major QTL - Frontiers
• Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation - Nature
• Predicting epistasis across proteins by structural logic - PNAS
• Epistasis and co-adaptation in bacterial genome evolution - Nature
• Favorable epistasis in ancestral diterpene synthases promoted convergent evolution of a resin acid precursor in conifers - PNAS
• Protein-protein interactions are a major source of epistasis in genetic interaction networks - Nature
• Epistasis regulates genetic control of cardiac hypertrophy - Nature
• Cryptic variation fuels plant phenotypic change through hierarchical epistasis - Nature
• Epistasis in cardiac traits - Nature
• Epistasis and Its Effects on Phenotype | Learn Science at Scitable - Nature
• Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning - Nature
• Genome-Wide Epistatic Interaction Networks Affecting Feed Efficiency in Duroc and Landrace Pigs - Frontiers
• Epistatic Net allows the sparse spectral regularization of deep neural networks for inferring fitness functions - Nature
• Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence - Nature
• Epistatic models predict mutable sites in SARS-CoV-2 proteins and epitopes - PNAS
• In vivo functional phenotypes from a computational epistatic model of evolution - PNAS
• Epistatic interaction has the reverse effects with its constitutive quantitative trait loci - Nature
• Addressing epistasis in the design of protein function - PNAS
• Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes - Nature
• Epistatic mutations under divergent selection govern phenotypic variation in the crow hybrid zone - Nature
• Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems - Nature
• Genome instability drives epistatic adaptation in the human pathogen Leishmania - PNAS
• Network of epistatic interactions within a yeast snoRNA - Science | AAAS
• Nested epistasis enhancer networks for robust genome regulation - Science | AAAS
• Distributed transformer for high order epistasis detection in large-scale datasets - Nature
• Learning the pattern of epistasis linking genotype and phenotype in a protein - Nature
• Epistatic Effect of Regulators to the Adaptive Growth of Escherichia coli - Nature
• Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes - Wiley Online Library
• Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments - Nature
• Novel Alzheimer’s disease genes and epistasis identified using machine learning GWAS platform - Nature
• Screening for epistatic selection signatures: A simulation study - Nature
• A method for finding epistatic effects of maternal and fetal variants - Frontiers
• Environmental modulation of global epistasis in a drug resistance fitness landscape - Nature
• Epistatic interactions of genetic loci associated with age-related macular degeneration - Nature
• Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1 - Nature
• Epistasis-mediated compensatory evolution in a fitness landscape with adaptational tradeoffs - PNAS
• Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution - Nature
• Genome-wide discovery of epistatic loci affecting antibiotic resistance in Neisseria gonorrhoeae using evolutionary couplings - Nature
• Identification of epistatic SNP combinations in rheumatoid arthritis using LAMPLINK and Japanese cohorts - Nature
• An epistatic effect of KRT25 on SP6 is involved in curly coat in horses - Nature
• A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site - Nature
• Epistasis and the Evolution of Antimicrobial Resistance - Frontiers
• Genome-wide signatures of synergistic epistasis during parallel adaptation in a Baltic Sea copepod - Nature
• Emergent time scales of epistasis in protein evolution - PNAS
• Higher-order epistasis shapes natural variation in germ stem cell niche activity - Nature
• Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis - Nature
• Pleiotropy, epistasis and the genetic architecture of quantitative traits - Nature
• Epistasis shapes the fitness landscape of an allosteric specificity switch - Nature
• Repeatability of evolution on epistatic landscapes - Nature
• Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus - Frontiers
• Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase - Nature
• Development of epistatic YES and AND protein logic gates and their assembly into signalling cascades - Nature
• Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen - PNAS
• A quantitative genetic framework highlights the role of epistatic effects for grain-yield heterosis in bread wheat - Nature
• A survey about methods dedicated to epistasis detection - Frontiers
• An epistatic ratchet constrains the direction of glucocorticoid receptor evolution - Nature
• Idiosyncratic epistasis leads to global fitness–correlated trends - Science | AAAS
• Atlas of epistasis - medRxiv
• The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross - Nature
• Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology - Nature
• The contribution of epistasis to the architecture of fitness in an RNA virus - PNAS
• An Exhaustive Epistatic SNP Association Analysis on Expanded Wellcome Trust Data - Nature
• Analysis of Epistasis among QTLs on Heading Date based on Single Segment Substitution Lines in Rice - Nature
• Detecting CSSLs and yield QTLs with additive, epistatic and QTL×environment interaction effects from Oryza sativa O. nivara IRGC81832 cross - Nature
• Minimum epistasis interpolation for sequence-function relationships - Nature
• Genome-wide epistasis analysis in Parkinson’s disease between populations with different genetic ancestry reveals significant variant-variant interactions - medRxiv
• Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape - Nature
• Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders - Frontiers
• Epistatic interactions of major effect drought QTLs with genetic background loci determine grain yield of rice under drought stress - Nature
• Widespread genetic epistasis among cancer genes - Nature
• Synergistic epistasis enhances the co-operativity of mutualistic interspecies interactions - Nature
• Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme - Nature
• Inter-laboratory evolution of a model organism and its epistatic effects on mutagenesis screens - Nature
• Epistasis: Gene Interaction and the Phenotypic Expression of Complex Diseases Like Alzheimer's - Nature
• Epistatic hotspots organize antibody fitness landscape and boost evolvability - PNAS
• Mechanistic causes of sign epistasis and its applications - Frontiers
• Adaptive evolutionary paths from UV reception to sensing violet light by epistatic interactions - Science | AAAS
• Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of the influenza A virus - PNAS
• Genome-wide epistasis analysis reveals gene–gene interaction network on an intermediate endophenotype P-tau/Aβ - Nature
• Negative dominance and dominance-by-dominance epistatic effects reduce grain-yield heterosis in wide crosses in wheat - Science | AAAS
• Epistasis and quantitative traits: using model organisms to study gene–gene interactions - Nature
• Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease - Nature
• Epistatic Interaction of ERAP1 and HLA-B*51 in Iranian Patients with Behçet’s Disease | Scientific Reports - Nature
• Structural and molecular basis of the epistasis effect in enhanced affinity between SARS-CoV-2 KP.3 and ACE2 - Nature
• Estimating directional epistasis - Frontiers
• Correction: Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models | PLOS One - PLOS
• Characterization of Epistatic Interaction of QTLs LH8 and EH3 Controlling Heading Date in Rice | Scientific Reports - Nature
• Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean - PNAS
• Epistasis correlates to genomic complexity - PNAS
• QTL epistasis plays a role of homeostasis on heading date in rice - Nature
• Expression of Concern: Epistatic interactions between PHOTOPERIOD1, CONSTANS1 and CONSTANS2 modulate the photoperiodic response in wheat | PLOS Genetics - PLOS
• Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes - Frontiers
• Gene-gene interactions contribute to autism - Simons Foundation Autism Research Initiative | SFARI