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The Epstein–Barr virus, also known as human herpesvirus 4 (HHV-4), is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. EBV is the first identified oncogenic virus, a virus that can cause cancer. EBV establishes a permanent infection in human B cells. It is the most common cause of infectious mononucleosis and is also tightly linked to many malignant diseases. Various vaccine formulations have been tested in humans and other animals, however none of them were able to prevent EBV infection; thus, no vaccine has been approved to date.
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.