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The eukaryotic large ribosomal subunit (60S) is denoted according to its sedimentation coefficients in Svedberg units. The 60S subunit is the large subunit of the eukaryotic ribosome (S80), with the other major component being the eukaryotic small ribosomal subunit (40S). It is structurally and functionally related to the 50S subunit of 70S prokaryotic ribosomes. However, the 60S subunit is much larger than the prokaryotic 50S subunit and contains many additional protein segments, as well as ribosomal RNA expansion segments.
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