Why is "Exon" trending?

Search Interest Perspective

• Emerging TKIs Drive Renewed Progress in EGFR Exon 20 Insertion–Positive NSCLC - OncLive
• A decade ago, these drugs tore apart the FDA. Today, they might be some patients' best hope - statnews.com
• Exon-skipping approach boosts levels of key Rett syndrome protein - The Transmitter
• Houston Dynamo FC loan forward Exon Arzú to Real C.D. España in Honduras - Houston Dynamo FC
• Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics - Nature
• Sunvozertinib Monotherapy Bests Platinum-Doublet Chemotherapy in EGFR Exon 20+ NSCLC - OncLive
• Exceptional response to furmonertinib in lung adenocarcinoma harboring HER2 exon 20 insertion mutation: a case report - Frontiers
• EGFR and Lung Cancer - American Lung Association
• Andamertinib Effective in NSCLC With EGFR Exon 20 Insertion Mutation - AJMC
• Sarepta’s DMD Exon-Skippers Fail Confirmatory Study, Stock Craters - BioSpace
• Phylogenomic profile of exon-intron organization across angiosperms, their relationships with protein domains, and functional implications - Nature
• Gene regulation through exon junction complex modularity - Nature
• NDA for Zipalertinib in Pretreated NSCLC With EGFR Exon 20 Insertion Mutations Is Submitted to the FDA - OncLive
• The Landscape of EGFR Exon 20-Positive Lung Cancer Treatment - Targeted Oncology
• A portable poison exon for small-molecule control of mammalian gene expression - Nature
• INCA033989 With/Without Ruxolitinib Drives Spleen and Anemia Responses in CALR Exon 9–Mutated Myelofibrosis - OncLive
• Current and Emerging Options for Uncommon EGFR- and Exon 20 Insertion–Mutated NSCLC - AJMC
• Comprehensive map of the regulatory network triggered by MET exon 14 skipping reveals important involvement of the RAS-ERK signaling pathway - Nature
• Poziotinib for EGFR exon 20-insertion NSCLC: Clinical efficacy of the phase 2 ZENITH trial and differential impact of EGFR exon 20 insertion location on sensitivity - Nature
• Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing - Nature
• Sunvozertinib Approval Fills Treatment Gap in Pretreated EGFR Exon 20–Mutant NSCLC - OncLive
• PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expression - Nature
• Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation - Frontiers
• DOLPHIN advances single-cell transcriptomics beyond gene level by leveraging exon and junction reads - Nature
• Long-read RNA sequencing unveils a novel cryptic exon in MNAT1 along with its full-length transcript structure in TDP-43 proteinopathy - Nature
• Genetic and clinical characteristics of Japanese cystinuria with exon and exon–intron boundary variants - Nature
• Alternative Splicing of Exon 23a in Neurofibromatosis Type 1 Pre-mRNA: Its Contribution to the Protein Structure and Function of Neurofibromin - Wiley Interdisciplinary Reviews
• MET exon 14 skipping mutations in non-small-cell lung cancer a 3 years screening experience - Nature
• FDA Clears Oncomine Dx Express Test for Sunvozertinib in EGFR Exon 20+ NSCLC - Targeted Oncology
• DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function - Nature
• FDA Grants Accelerated Approval to Sunvozertinib for Metastatic NSCLC With EGFR Exon 20 Insertion Mutations - The ASCO Post
• Clinical applications of exon-skipping antisense oligonucleotides in neuromuscular diseases - ScienceDirect.com
• Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction - Nature
• Takeda to Voluntarily Withdraw Mobocertinib for EGFR Exon 20 Insertion+ NSCLC - OncLive
• Dizal's US first; now what? | ApexOnco - Clinical Trials news and analysis - Oncology Pipeline
• FDA Grants Accelerated Approval to Sunvozertinib for EGFR Exon 20 Insertion Mutations in NSCLC - Oncodaily
• Houston Dynamo FC sign Honduran National Team attacker Exon Arzú on full transfer from Real C.D. España - Houston Dynamo FC
• Recent Developments in Targeting EGFR Exon 20 Mutations in Non–Small Cell Lung Cancer - ASCO Daily News
• Differential exon usage of developmental genes is associated with deregulated epigenetic marks - Nature
• Capmatinib in MET exon 14-mutated non-small-cell lung cancer: final results from the open-label, phase 2 GEOMETRY mono-1 trial - The Lancet
• Structural insights into the cross-exon to cross-intron spliceosome switch - Nature
• Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model - Nature
• Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease - Nature
• Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects - Nature
• Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib | Leukemia - Nature
• EGFR Exon 20 Lung Cancer – New Treatment Options and Detection Methods - American Lung Association
• EGFR Therapies Fail to Benefit Patients With NSCLC and Exon 20 Insertions - Targeted Oncology
• Multinational proficiency tests for EGFR exon 20 insertions reveal that the assay design matters - Nature
• Exon architecture controls mRNA m6A suppression and gene expression - Science | AAAS
• Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons | Translational Psychiatry - Nature
• Regulation of micro- and small-exon retention and other splicing processes by GRP20 for flower development - Nature
• Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression - Nature
• FDA Approves Amivantamab for EGFR-Positive NSCLC With Exon 19 Deletion, Exon 21 L858R Substitution - AJMC
• Exon-junction complex association with stalled ribosomes and slow translation-independent disassembly - Nature
• Tepotinib in Non–Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations - NEJM
• Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5 - Nature
• Novel FBN1 intron variant causes isolated ectopia lentis via in-frame exon skipping - Nature
• Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue - Nature
• Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer - Nature
• Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease - PNAS
• Exon-skipping antisense oligonucleotides for cystic fibrosis therapy - PNAS
• The same genomic variants in the first three exons of KANSL1 can be either benign or causative of Koolen-de Vries syndrome: Definition of a validation procedure - ScienceDirect.com
• FDA Grants Accelerated Approval for Sunvozertinib (Zegfrovy) in NSCLC - Oncology News Central
• John Cody Exon Obituary April 17, 2023 - Russon Mortuary & Crematory - Russon Brothers
• Savolitinib Earns Full Approval in China for Locally Advanced/Metastatic MET Exon 14+ NSCLC - OncLive
• Exon junction complex shapes the m - Nature
• Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions - NEJM
• Structural insights into human exon-defined spliceosome prior to activation - Cell Research - Nature
• Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing - Science | AAAS
• The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity - Nature
• TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A - Nature
• Capmatinib in MET Exon 14–Mutated or MET -Amplified Non–Small-Cell Lung Cancer - NEJM
• EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment - Nature
• Why EGFR Exon 21 L858R Mutations Should Be Treated Differently - European Medical Journal
• Antisense-mediated exon skipping targeting EZH2 suppresses tumor growth in a xenograft mouse model of hepatocellular carcinoma - ScienceDirect.com
• Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations - Nature
• Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis - Nature
• Current Treatments for EGFR Exon 20 Insertion+ NSCLC - Targeted Oncology
• Exon-Skipping Therapy for DMD Linked to High Care Costs, Health Care Resource Utilization - AJMC
• Marcia Horn Discusses Advancements in EGFR Exon 20 Insertion+ NSCLC and the Importance of Community - AJMC
• The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients - Nature
• CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells - Science | AAAS
• Teaching NeuroImages: CNS hemangioblastomas in von Hippel-Lindau disease with exon 3 deletion - Neurology® Journals
• Next generation sequencing is a highly reliable method to analyze exon 7 deletion of survival motor neuron 1 ( SMN1 ) gene - Nature
• The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons - Science | AAAS
• Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping - Nature
• Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing - Nature
• FDA Rejects HER2 Exon 20-Targeted Therapy for Lung Cancer - Oncology News Central
• Sarepta Therapeutics Announces FDA Clearance of IND for the Company’s PPMO Exon 51 Candidate, SRP-5051 - Sarepta Therapeutics
• Impact of Exon 1 polymorphism in the MBL2 gene on MBL serum levels and infection susceptibility in acute lymphoid leukemia - Nature
• Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts - Nature
• A second hotspot for pathogenic exon-skipping variants in CDC45 | European Journal of Human Genetics - Nature
• Houston Dynamo sign Honduran forward Exon Arzú - MLSsoccer.com
• A distribution hallmark, longer mRNA half-life and flexible protein coding - Nature
• Newborn screening of duchenne muscular dystrophy specifically targeting deletions amenable to exon-skipping therapy - Nature
• Non-invasive and high-throughput interrogation of exon-specific isoform expression - Nature
• The role of D4 receptor gene exon III polymorphisms in shaping human altruism and prosocial behavior - Frontiers
• A first exon termination checkpoint preferentially suppresses extragenic transcription - Nature
• Poziotinib is active in EGFR exon 20 mutant non-small cell lung cancer with efficacy highly dependent on insertion location - UT MD Anderson
• Therapeutic Advances for Metastatic NSCLC With EGFR Exon 20 Insertion Mutations - Cancer Therapy Advisor