Why is "G protein" trending?

Search Interest Perspective

• The structure and function of taste G protein-coupled receptors and their implications in diseases - Nature
• G protein-coupled receptor (GPCR) - Britannica
• Structural determinants of G protein subtype selectivity at the serotonin receptor 5-HT1A - Science | AAAS
• The dynamic basis of G-protein recognition and activation by a GPCR - Nature
• Ubiquitin-driven G protein-coupled receptor inflammatory signaling at the endosome - American Physiological Society Journal
• Structure and dynamics determine G protein coupling specificity at a class A GPCR - Science | AAAS
• The therapeutic potential of orphan adhesion G-protein-coupled receptors - Nature
• A structural overview of G-protein-coupled receptors in neurological disorders | Acta Pharmacologica Sinica - Nature
• Activation dynamics traced through a G protein–coupled receptor by 81 1H-15N NMR probes - Science | AAAS
• Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity - Nature
• Conformational biosensors delineate endosomal G protein regulation by GPCRs - Nature
• Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature
• Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis - Nature
• Identifying the biomarkers associated with G protein-coupled receptors of parkinson’s disease - Nature
• Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors - Nature
• Activation of cytomegalovirus-encoded G protein-coupled receptor UL33 by an innate N-terminal peptide - Nature
• Insights into G-protein coupling preference from cryo-EM structures of G - Nature
• Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors - Nature
• Structural insights into ligand recognition and G protein preferences across histamine receptors - Nature
• Multiple intramolecular triggers converge to preferential G protein coupling in the CB - Nature
• G Protein-Coupled Receptors and Their Role as Drug Targets - the-scientist.com
• Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation - PNAS
• G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders - Nature
• G Protein-Coupled Receptors: A Century of Research and Discovery - American Heart Association Journals
• Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery - Nature
• G-Protein–Coupled Receptors in Heart Disease - American Heart Association Journals
• Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity - Nature
• G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery - Nature
• GPCR | Learn Science at Scitable - Nature
• Time-resolved cryo-EM of G-protein activation by a GPCR - Nature
• Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor - Nature
• G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding - Nature
• Promiscuous G-protein activation by the calcium-sensing receptor - Nature
• Investigating G-protein coupled receptor signalling with light-emitting biosensors - Frontiers
• Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function - Frontiers
• Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor - Nature
• Ligand and G-protein selectivity in the κ-opioid receptor - Nature
• The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites - Nature
• Binding kinetics drive G protein subtype selectivity at the β - Nature
• Mechanisms of signalling and biased agonism in G protein-coupled receptors - Nature
• G-protein-coupled receptors and cancer - Nature
• The role of G protein conformation in receptor–G protein selectivity - Nature
• Fusion protein strategies for cryo-EM study of G protein-coupled receptors - Nature
• Coevolution underlies GPCR-G protein selectivity and functionality - Nature
• Restructuring G-Protein- Coupled Receptor Activation - ScienceDirect.com
• GPCRs (G-Protein–Coupled Receptors) as Microprocessors: - American Heart Association Journals
• G protein peptidomimetics reveal allosteric effects and stepwise interactions in ghrelin receptor–G protein coupling - Science | AAAS
• Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design - Nature
• GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach - Nature
• Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors - Nature
• Stickier G-protein conformations - Nature
• G-protein activation by a metabotropic glutamate receptor - Nature
• Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55 - Nature
• Fine-tuning activation specificity of G-protein-coupled receptors via automated path searching - PNAS
• Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity - Nature
• Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes - Nature
• Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery - Nature
• Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury - Nature
• Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5 - PNAS
• Structural insights into G protein activation by D1 dopamine receptor - Science | AAAS
• Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors - Science | AAAS
• Understanding Ligand Binding to G-Protein Coupled Receptors Using Multiscale Simulations - Frontiers
• ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells - Nature
• Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor - Nature
• Analyzing kinetic signaling data for G-protein-coupled receptors - Nature
• G Protein-Coupled Receptor (GPCR) Collaborative - St. Jude Children's Research Hospital
• Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape - Nature
• Histamine-modulated wettability switching in G-protein-coupled receptor inspired nanochannel for potential drug screening and biosensing - Nature
• Heterotrimeric G protein activation by G-protein-coupled receptors - Nature
• Balancing G protein selectivity and efficacy in the adenosine A - Nature
• Fingerprinting G protein–coupled receptor signaling - Science | AAAS
• Some G protein heterotrimers physically dissociate in living cells - PNAS
• Covalent agonists for studying G protein-coupled receptor activation - PNAS
• Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs - Nature
• Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET - Nature
• Coding GPCR-G protein specificity - Nature
• Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides - PNAS
• Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor - Nature
• G-protein activation live - Nature
• Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation | npj Systems Biology and Applications - Nature
• G Protein-Coupled Receptors in Taste Physiology and Pharmacology - Frontiers
• G protein coupled receptor transcripts in human immune cells and platelets - Nature
• Anionic phospholipids control mechanisms of GPCR-G protein recognition - Nature
• Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel - Nature
• Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1 - Nature
• receptor regulate psychosis-related effects and memory deficits - Nature
• Orphan G protein-coupled receptors: the ongoing search for a home - Frontiers
• Illuminating dynamics of G -protein-coupled receptors - St. Jude Children's Research Hospital
• Ligand-induced activation and G protein coupling of prostaglandin F - Nature
• Fine-tuning receptor–G protein activation and signaling - Science | AAAS
• Conformation- and activation-based BRET sensors differentially report on GPCR–G protein coupling - Science | AAAS
• Structural insight into apelin receptor-G protein stoichiometry - Nature
• Molecular basis for the selective G protein signaling of somatostatin receptors - Nature
• Growth factor–dependent phosphorylation of Gαi shapes canonical signaling by G protein–coupled receptors - Science | AAAS
• Space and time influence G-protein coupled receptor interactions - St. Jude Children's Research Hospital
• Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists - PNAS
• Structural insights into G-protein-coupled receptor allostery - Nature
• Building unconventional G protein-coupled receptors, one block at a time - ScienceDirect.com
• Development of an antibody fragment that stabilizes GPCR/G-protein complexes - Nature
• Computational design of G Protein-Coupled Receptor allosteric signal transductions - Nature