Why is "Hereditary spherocytosis" trending?
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- Date: 2026-04-01 14:10:35
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Hereditary spherocytosis (HS) is a congenital hemolytic disorder wherein a genetic mutation coding for a structural membrane protein phenotype causes the red blood cells to be sphere-shaped (spherocytosis), rather than the normal biconcave disk shape. This abnormal shape interferes with the cells' ability to flex during blood circulation, and also makes them more prone to rupture under osmotic stress, mechanical stress, or both. Cells with the dysfunctional proteins are degraded in the spleen, which leads to a shortage of erythrocytes and results in hemolytic anemia.
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Search Interest Perspective
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Genotype clinical phenotype analysis of 35 cases of hereditary spherocytosis in children - Frontiers
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Confounding Factors in the Diagnosis of Hereditary Spherocytosis and Gallstone Formation in Related Hemolytic Disorders From a Tertiary Care Center in North India - Cureus
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Changing the Game: Bronson’s hereditary spherocytosis story - KY3
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Hereditary Spherocytosis due to an SPTA1 Nonsense Mutation Coinherited With α spectrinLELY in Trans - Wiley Online Library
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Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report - Frontiers
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Parvovirus B19-Induced Aplastic Crisis and Hemophagocytic Lymphohistiocytosis in a Child With Hereditary Spherocytosis - Cureus
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Identification and functional analysis of novel SPTB and ANK1 mutations in hereditary spherocytosis patients - Nature
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Can the CBC Be Used to Diagnose Hereditary Spherocytosis in Newborns? - AAP
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Yale doctors crack the code of a rare, inherited anemia - YaleNews
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A novel ANK1 frameshift mutation associated with neonatal hereditary spherocytosis: a case report - Frontiers
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The diagnostic protocol for hereditary spherocytosis‐2021 update - Wu - 2021 - Journal of Clinical Laboratory Analysis - Wiley Online Library
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SPTA1-Related Hereditary Spherocytosis: Novel Compound Heterozygous Mutations With Severe Clinical Manifestation - Cureus
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Temporal trends of splenectomy in pediatric hospitalizations with hereditary spherocytosis from 2000 to 2019: A national survey - Wiley Online Library
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Clinical characteristics of hereditary spherocytosis with red blood cell membrane protein gene variants - Frontiers
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Splenic Artery Embolization as a Primary Treatment for Hereditary Spherocytosis: A Case Report - Cureus
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Stress erythropoiesis in hereditary spherocytosis - Haughton - 2020 - American Journal of Hematology - Wiley Online Library
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An overview of hereditary spherocytosis and the curative effects of splenectomy - Frontiers
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Case Report: Post-splenectomy bulky pelvic splenosis in an adolescent with hereditary spherocytosis - Frontiers
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Hereditary Spherocytosis With Liver Transplantation After Cirrhosis: A Case Report - Frontiers
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Gallbladder preserving cholelithotomy in children with hereditary spherocytosis complicated by gallstones: a single-center retrospective study - Frontiers
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Bursting the bubble: hereditary spherocytosis masking poor glycemic control - American Osteopathic Association | AOA
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Super-Selective Partial Splenic Embolization for Hereditary Spherocytosis in Children: A Single-Center Retrospective Study - Frontiers
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Recurrent Acute Splenic Sequestration Crisis Due to Interacting Genetic Defects: Hemoglobin SC Disease and Hereditary Spherocytosis - ScienceDirect.com
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Parvovirus-Induced Transient Aplastic Crisis in a Patient With Newly Diagnosed Hereditary Spherocytosis - Cureus
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Young Boy With Anemia Caused by Hereditary Spherocytosis - Consultant360
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The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis - Nature
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Novel hereditary spherocytosis-associated splice site mutation in the ANK1 gene caused by parental gonosomal mosaicism - Haematologica
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Reply to “Flow cytometry test for hereditary spherocytosis”. Haematologica. 2012;97(12):e47 - Haematologica
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A novel essential splice site variant in SPTB in a large hereditary spherocytosis family - Wiley Online Library
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Intraoperative Cell-Saver Caused More Autologous Salvage Hemolysis in a Hereditary Spherocytosis Patient Than in a Normal Erythrocyte Patient - Frontiers
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Identification of a novel ANK1 mutation in hereditary spherocytosis co‐existing with BWS - Wiley Online Library
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Transcatheter Closing Atrial Septal Defect in a Child With Hereditary Spherocytosis - Frontiers
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Drug-induced liver injury from Deferasirox in a pediatric patient with hereditary spherocytosis: A case report - Wiley Online Library
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Hereditary spherocytosis associated with Noonan syndrome mimicking a dyserythropoietic anaemia - Wiley Online Library
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Flow Cytometric Analysis of Erythrocytes Osmotic Fragility in Hereditary Spherocytosis: A Case-Controlled Study Evaluating the Best Anticoagulant, Sample Pre-Treatment and NaCl Concentration for Reliable Screening of this Red Blood Cell Membrane Disor - Wiley Online Library
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Effect of primary lesions in cytoskeleton proteins on red cell membrane stability in patients with hereditary spherocytosis - Frontiers
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Malnutrition from anorexia nervosa triggers severe complications of hereditary spherocytosis in an adolescent girl: A case report - Wiley Online Library
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Comparison of a modified flow cytometry osmotic fragility test with the classical method for the diagnosis of hereditary spherocytosis - Wiley Online Library
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Evaluating eosin-5-maleimide binding as a diagnostic test for hereditary spherocytosis in newborn infants - Nature
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Improving the EMA Binding Test by Using Commercially Available Fluorescent Beads - Frontiers
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Facilitating EMA binding test performance using fluorescent beads combined with next-generation sequencing - Wiley Online Library
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A patient with pancreatitis, anaemia and an intrathoracic tumour - ERS - European Respiratory Society
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Using the eosin-5-maleimide binding test in the differential diagnosis of hereditary spherocytosis and hereditary pyropoikilocytosis - Wiley Online Library
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‘Is there no way to stop this?’: Hit by hereditary blood disorder across 3 generations, Pune family wonders how many more - The Indian Express
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A young man with acute abdomen and anaemia - Tidsskrift for Den norske legeforening
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Hereditary red cell membrane disorders and laboratory diagnostic testing - Wiley Online Library
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Partial Ankyrin and Spectrin Deficiency in Severe, Atypical Hereditary Spherocytosis - NEJM
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Blood disorder blamed for death of athlete, 15 - Toledo Blade
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Covid-19: London teenage girl one of youngest to get vaccine - BBC
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Nurse highlights son’s rare blood condition - Suffolk News
Why This Topic Is Trending
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