Why is "Hsp70" trending?

Search Interest Perspective

• Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response - Nature
• Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer - Science | AAAS
• Recent insights into HSP70: proteostasis and beyond - Frontiers
• Bi-A@SR Nanoparticles Enable Tumor-Localized NO Release to Suppress HSP70 and Reverse Chemoresistance - Wiley
• Unfolding the role of Hsp70 chaperones in neurodegeneration - News-Medical
• Mechanisms and regulation of the Hsp70 chaperone network - Nature
• Inhibition of the assembly of Plasmodium Hsp70-1 and Hsp40 complex blocks DNA replication by destabilizing ribonucleotide reductase subunit-2 - ASM Journals
• The regulatory role of heat shock protein 70 in modulating mitochondrial antioxidant defense systems in Esox lucius during post-mortem storage - ScienceDirect.com
• The Presence of Heat Shock Protein 70 (HSP70) Antibodies in Bilateral Meniere’s Disease: A Case Report - Cureus
• First complete structures of heat shock chaperone protein complex reveal handoff mechanism - Phys.org
• mtHsp70 chaperone converts mitochondrial proteostasis stress into impaired protein import - PNAS
• Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes - American Heart Association Journals
• Divergent roles of Hsp70 chaperones in orthoflavivirus protein secretion and virion formation - Nature
• Inhibition of the assembly of Plasmodium Hsp70-1 and Hsp40 complex blocks DNA replication by destabilizing ribonucleotide reductase subunit-2 - ASM Journals
• The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb - Nature
• TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins - Nature
• Increased circulating heat shock protein Hsp70 serum levels as a potential biomarker in bronchial asthma patients - Nature
• The Hsp70 chaperone network - Nature
• HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer - Nature
• Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer - Nature
• Single-molecule evidence of Entropic Pulling by Hsp70 chaperones - Nature
• Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain - Nature
• The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations - Frontiers
• The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase - Nature
• The HSP70 chaperone machinery: J proteins as drivers of functional specificity - Nature
• Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target - Frontiers
• Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis - Nature
• A fluorescent multi-domain protein reveals the unfolding mechanism of Hsp70 - Nature
• The complex evolution of the metazoan HSP70 gene family - Nature
• Hsp70-containing extracellular vesicles are capable of activating of adaptive immunity in models of mouse melanoma and colon carcinoma - Nature
• Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments - Nature
• Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein - Nature
• Pathway of Hsp70 interactions at the ribosome - Nature
• Substrate-binding domain conformational dynamics mediate Hsp70 allostery - PNAS
• HSP40 proteins use class-specific regulation to drive HSP70 functional diversity - Nature
• HSP70 is a negative regulator of NLRP3 inflammasome activation - Nature
• Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism - Nature
• Molecular dissection of amyloid disaggregation by human HSP70 - Nature
• Oligomerization of Hsp70: Current Perspectives on Regulation and Function - Frontiers
• Differential expression and regulation of HSP70 gene during growth phase in ruminants in response to heat stress - Nature
• The anti-inflammatory mechanisms of Hsp70 - Frontiers
• Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody - PNAS
• The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism - Nature
• The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation - Nature
• HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells - Science | AAAS
• Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone - Nature
• HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3 - Nature
• DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones - Nature
• Feedback control of the heat shock response by spatiotemporal regulation of Hsp70 - Rockefeller University Press
• The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation - Nature
• Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress - Nature
• Expression analysis of the apple HSP70 gene family in abiotic stress and phytohormones and expression validation of candidate MdHSP70 genes - Nature
• Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding - Nature
• Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome - PNAS
• Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a murine model of deep vein thrombosis - Nature
• Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor - Nature
• Pathways of allosteric regulation in Hsp70 chaperones - Nature
• Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer’s disease - Nature
• An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back - Nature
• ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation - Nature
• Heat shock protein 70 kDa (HSP70) is involved in the maintenance of pig sperm function throughout liquid storage at 17 °C - Nature
• Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis - Nature
• Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia - Nature
• ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation - Nature
• Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations - Nature
• USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization - Science | AAAS
• Metazoan Hsp70-based protein disaggregases: emergence and mechanisms - Frontiers
• The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain - PNAS
• The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance - Haematologica
• Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation | Cell Research - Nature
• Heat stress-induced heat shock protein 70 (HSP70) expressions among vulnerable populations in urban and rural areas Klang Valley, Malaysia - Nature
• Environmental stress and hypertension: the disregarded role of HSP70 - Nature
• The Hsp70 Gene Family in Solanum tuberosum : Genome-Wide Identification, Phylogeny, and Expression Patterns - Nature
• The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70 - Nature
• A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms | Scientific Reports - Nature
• The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases - Frontiers
• A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase - Nature
• Research study at Hollings points to new combination strategy for pancreatic cancer - The Medical University of South Carolina
• Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation - Frontiers
• Assessing Spikelet Fertility and HSP70 for Heat Tolerance - Bioengineer.org
• Cochaperones enable Hsp70 to use ATP energy to stabilize native proteins out of the folding equilibrium - Nature
• Alternative modes of client binding enable functional plasticity of Hsp70 - Nature
• Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation - Nature
• OLA1 protects cells in heat shock by stabilizing HSP70 - Nature
• Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules - Nature
• X-ray reflectivity study of the heat shock protein Hsp70 interaction with an artificial cell membrane model - Nature
• Multilevel interaction of the DnaK/DnaJ(HSP70/HSP40) stress-responsive chaperone machine with the central metabolism - Nature
• Sequence analysis of the Hsp70 family in moss and evaluation of their functions in abiotic stress responses - Nature
• Multistep mechanism of substrate binding determines chaperone activity of Hsp70 - Nature
• The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion - Nature
• Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology - Nature
• Structural and functional analysis of the Hsp70/Hsp40 chaperone system - Liu - 2020 - Protein Science - Wiley Online Library
• Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 - Nature
• Sequence and expression analysis of HSP70 family genes in Artemia franciscana - Nature
• Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation - Nature
• Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors - Science | AAAS
• Functional Specificity Among Hsp70 Molecular Chaperones - Science | AAAS
• Stimulation of gastric ulcer healing by heat shock protein 70 - ScienceDirect.com
• Hydrogel-based delivery of Tat-fused protein Hsp70 protects dopaminergic cells in vitro and in a mouse model of Parkinson’s disease - Nature
• Action of the Hsp70 chaperone system observed with single proteins - Nature