Why is "Hsp90" trending?

Search Interest Perspective

• Structural basis for chaperone-guided assembly of RNA-induced silencing complex - Nature
• Hsp90 and associates shaping parasite biology - ASM Journals
• Study uncovers hidden class of BRCA1 mutations and a potential way to target them - UT MD Anderson
• Hsp90 as a pathophysiological factor and emerging therapeutic target in atopic dermatitis - Frontiers
• Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells | Cell Death & Disease - Nature
• Correction: Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle - PLOS
• Integrative Database-Driven In Silico and In Vitro Study of Anemarrhena asphodeloides Bunge Highlighting Hippeastrine as a Regulator of the HSP90/PI3K/Akt/mTOR Axis in Oral Squamous Cell Carcinoma - Wiley
• PARP Inhibitor Resistance in BRCA1 Breast Cancer Could Be Addressed by Targeting HSP90 - Inside Precision Medicine
• Suppression of Hsp90 expression in Aspergillus fumigatus enhances sensitivity to oxidative stress and activates host cell NF-κB p65 and ERK signaling pathways - ASM Journals
• Molecular mechanism of PINK1 regulation by the Hsp90 machinery - Nature
• Genome-wide comparative analysis of the HSP90 gene family in four Ipomoea species and functional insights into the potentiality of IbHSP90-2 in low temperature tolerance - Frontiers
• Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis - Wiley
• HSP90 as an evolutionary capacitor drives adaptive eye size reduction via atonal - Nature
• A small-molecule HSP90 inhibitor, NVP-HSP990, alleviates rotavirus infection - ASM Journals
• Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction - Nature
• HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane - Nature
• ATP plays a structural role in Hsp90 function - Nature
• ATG5–HSP90.2-mediated micromitophagy as a cytological basis for maternal inheritance of plant mitochondria - Nature
• Topical application of the HSP90 inhibitor 17-AAG reduces skin inflammation and partially restores microbial balance: implications for atopic dermatitis therapy - Nature
• Chimeric Small Molecule Drug Conjugate Effectively Targets Solid Tumors - Genetic Engineering and Biotechnology News
• Structural and functional complexity of HSP90 in cellular homeostasis and disease - Nature
• Evolution of the conformational dynamics of the molecular chaperone Hsp90 - Nature
• Dr. LaPointe's Lab Reveals Co-operation Isn’t Always Key - University of Alberta
• Cochaperones convey the energy of ATP hydrolysis for directional action of Hsp90 - Nature
• Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism - Nature
• The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding - Nature
• Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells - Nature
• Visualizing the transiently populated closed-state of human HSP90 ATP binding domain - Nature
• Expression of membrane Hsp90 is a molecular signature of T cell activation - Nature
• HSP90 mediates the connection of multiple programmed cell death in diseases - Nature
• HSP90 multi-functionality in cancer - Frontiers
• HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer - Science | AAAS
• Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor - Nature
• Hsp90 provides a platform for kinase dephosphorylation by PP5 - Nature
• HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation - Nature
• Nucleotide exchange is sufficient for Hsp90 functions in vivo - Nature
• HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation - Nature
• Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex - Nature
• Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90 - Nature
• The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range - Nature
• Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life - Nature
• Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network - Science | AAAS
• Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition | Cell Death & Differentiation - Nature
• Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism - Nature
• Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment | Scientific Reports - Nature
• Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex - Nature
• The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation - Nature
• The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium - Nature
• Identification of HSP90 inhibitors as a novel class of senolytics - Nature
• Structural basis for the dynamic chaperoning of disordered clients by Hsp90 - Nature
• Glucocorticoid receptor complexes form cooperatively with the Hsp90 co-chaperones Pp5 and FKBPs - Nature
• Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus - Nature
• Design, synthesis and biological studies of new isoxazole compounds as potent Hsp90 inhibitors - Nature
• Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression - Frontiers
• Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation - Nature
• The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism - Nature
• New Class of Hsp90 C-Terminal Domain Inhibitors with Anti-tumor Properties against Triple-Negative Breast Cancer - ACS Publications
• Pervasive contingency and entrenchment in a billion years of Hsp90 evolution - PNAS
• The Onset of Molecule‐Spanning Dynamics in Heat Shock Protein Hsp90 - Wiley
• Critical regulation of TGFβ signaling by Hsp90 - PNAS
• Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer - Nature
• Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer - Science | AAAS
• The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells - Nature
• Hsp90 interacts with multiple dengue virus 2 proteins - Nature
• Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 - Nature
• A switch point in the molecular chaperone Hsp90 responding to client interaction - Nature
• Targeting the dynamic HSP90 complex in cancer - Nature
• The Mechanism of Hsp90 ATPase Stimulation by Aha1 - Nature
• Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome - PNAS
• HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1 - Nature
• The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function - PNAS
• Mutations in Hsp90 Cochaperones Result in a Wide Variety of Human Disorders - Frontiers
• Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures - Nature
• HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis - PNAS
• Regulation of survivin function by Hsp90 - PNAS
• Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish - Science | AAAS
• The mechanism of Hsp90-induced oligomerizaton of Tau - Science | AAAS
• The Differential Roles of HSP90 Isoforms in Skin Inflammation: Anti-Inflammatory Potential of TRAP1 Inhibition - ScienceDirect.com
• HSP90 interacts with VP37 to facilitate the cell-to-cell movement of broad bean wilt virus 2 - ASM Journals
• Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone - Nature
• Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome - Nature
• HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine - Nature
• HSP90 at the hub of protein homeostasis: emerging mechanistic insights - Nature
• HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons - Nature
• hsp90: Twist and Fold - ScienceDirect.com
• Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans - Nature
• RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex - Nature
• HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19 - Nature
• The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases - Frontiers
• Molecular chaperones: The busy life of Hsp90 - ScienceDirect.com
• Selection for robust metabolism in domesticated yeasts is driven by adaptation to Hsp90 stress - Science | AAAS
• Proteostatic tuning underpins the evolution of novel multicellular traits - Science | AAAS
• The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding - Nature
• The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach - Nature
• High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer - Nature
• A Dynamic View of ATP-coupled Functioning Cycle of Hsp90 N-terminal Domain - Nature
• Targeting HSP90 for cancer therapy - Nature
• The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells - Nature
• The Hsp90β Isoform: An Attractive Target for Drug Development - Chaudhury - 2025 - Medicinal Research Reviews - Wiley Online Library
• Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens - Nature