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Intrinsic or rho-independent termination is one of several natural mechanisms by which the process of transcription is terminated, causing the transcription complex to dissociate and the newly synthesized RNA molecule to be released from the DNA template. In bacteria such as E. coli, transcription is terminated either by a Rho-dependent or Rho-independent process. In the Rho-dependent process, the Rho protein locates and binds a signal sequence in the nascent RNA transcript and signals for cleavage. Contrarily, intrinsic termination does not require a special protein to signal termination but is instead facilitated by secondary structures formed by nucleotide sequences encoded within the nascent RNA itself.
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