Why is "Isovaleryl-CoA" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-04-09 23:18:33
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Isovaleryl-CoA is a metabolic intermediate formed during the catabolism of the branched-chain amino acid, leucine. It is a short-chain acyl-CoA thioester that plays a key role in mitochondrial energy metabolism. The compound is converted into 3-methylcrotonyl-CoA by the enzyme isovaleryl-CoA dehydrogenase (IVD), a flavoprotein that catalyzes the third step in the leucine degradation pathway. Deficiency of this enzyme activity results in the accumulation of isovaleryl-CoA and related metabolites, leading to a rare autosomal recessive disorder known as isovaleric acidemia, characterized by metabolic crises, developmental delays, and a distinctive odor due to isovaleric acid buildup. The metabolism of isovaleryl-CoA is vital for proper amino acid utilization and energy homeostasis in humans.
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Search Interest Perspective
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Structural Insights into Isovaleryl-Coenzyme A Dehydrogenase: Mechanisms of Substrate Specificity and Implications of Isovaleric Acidemia-Associated Mutations - Science Partner Journals
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Cryo-EM structures of isovaleryl-CoA dehydrogenase offers new therapeutic strategies for inherited isovaleric acidemia - EurekAlert!
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Recent advances in microbial 3-methyl-1-butanol production - Frontiers
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An Alternative Isovaleryl CoA Biosynthetic Pathway Involving a Previously Unknown 3-Methylglutaconyl CoA Decarboxylase - Wiley Online Library
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Isovaleric Acidemia: A Case Report - Cureus
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High-resolution native electrophoresis in-gel activity assay reveals biological insights of medium-chain fatty acyl-CoA dehydrogenase deficiency - Nature
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Functional annotation of putative fadE9 of Mycobacterium tuberculosis as isobutyryl-CoA dehydrogenase involved in valine catabolism - ScienceDirect.com
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Structure and DNA binding of alkylation response protein AidB - PNAS
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Acute Metabolic Decompensation of Isovaleric Acidemia Presenting as Persistent Metabolic Acidosis in a Middle-Aged Man: A Case Report - Cureus
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Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases - Nature
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Impact of Branched-Chain Amino Acid Catabolism on Fatty Acid and Alkene Biosynthesis in Micrococcus luteus - Frontiers
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Visualization of a radical B12 enzyme with its G-protein chaperone - PNAS
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Isovaleric Acidemia: A Rare Case of an Inborn Error of Metabolism - Cureus
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Mechanism of 3-Methylglutaconyl CoA Decarboxylase AibA/AibB: Pericyclic Reaction versus Direct Decarboxylation - Wiley Online Library
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Degradative Pathway of L-Leucine in Proteus vulgaris - Nature
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Respiratory electron transfer pathways in plant mitochondria - Frontiers
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2-Methylbutyryl-Coenzyme A Dehydrogenase Deficiency: A New Inborn Error of L-Isoleucine Metabolism - Nature
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Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (1H-NMR) | Scientific Reports - Nature
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Functional insights into the testis transcriptome of the edible sea urchin Loxechinus albus - Nature
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The role of photosynthesis and amino acid metabolism in the energy status during seed development - Frontiers
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Xanthomonas campestris FabH is required for branched-chain fatty acid and DSF-family quorum sensing signal biosynthesis - Nature
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A UDP-glucosyltransferase functions in both acylphloroglucinol glucoside and anthocyanin biosynthesis in strawberry ( Fragaria ananassa - Wiley Online Library
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