Why is "LRP1" trending?
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- Date: 2026-03-11 10:30:44
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Wikipedia Overview
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.
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Search Interest Perspective
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LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer’s disease - Frontiers
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Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV - Nature
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Inhibition of BMPER Mitigates Pulmonary Hypertension by Modulating LRP1-YAP Interaction in Smooth Muscle Cells - American Heart Association Journals
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Researchers develop novel Alzheimer's treatment to sidestep immune side effects - EurekAlert!
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Nanoparticles Potently Reverse Alzheimer’s in Mice - Lifespan Research Institute
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Nanoparticles reverse Alzheimer’s pathology in mice | UCL News - UCL - University College London
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New nanoparticle treatment helps brain to clear toxic Alzheimer’s proteins in mice - The Conversation
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LMO7 Suppresses Tumor-Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1 - Wiley
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Nanoparticle Therapy Promotes Aβ Clearance and Cognitive Recovery in Alzheimer’s Mouse Model - Genetic Engineering and Biotechnology News
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Scientists Reverse Alzheimer’s Symptoms in Mice Using Blood–Brain Barrier Therapy - European Medical Journal
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Nanoparticle therapy restores brain function in mice with Alzheimer’s disease - PsyPost
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EGFRvIII-positive glioblastoma contributes to immune escape and malignant progression via the c-Fos-MDK-LRP1 axis - Nature
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Multi-faceted role of LRP1 in the immune system - Frontiers
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LRP1 is a master regulator of tau uptake and spread - Nature
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Low-density lipoprotein receptor-related protein-1 (LRP1) in the glial lineage modulates neuronal excitability - Frontiers
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LRP1 Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases - American Heart Association Journals
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ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells - Nature
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The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment - Frontiers
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Putting the BBB back on track: supramolecular polymersomes for Alzheimer’s - BioWorld MedTech
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-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling - Nature
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LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin - Nature
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Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA - Nature
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Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1 - PNAS
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Nanoparticle Therapy Reverses Alzheimer’s in Mice - Technology Networks
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Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor–Related Protein-1) Maintains Arterial Integrity: - American Heart Association Journals
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Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening - Nature
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Low Density Lipoprotein Receptor-Related Protein-1 in Cardiac Inflammation and Infarct Healing - Frontiers
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Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue - Nature
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LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells - Nature
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Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin - Nature
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ApoE Receptor-2 R952Q Variant in Macrophages Elevates Soluble LRP1 to Potentiate Hyperlipidemia and Accelerate Atherosclerosis in Mice - American Heart Association Journals
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The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis - Frontiers
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γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 - Science | AAAS
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The fusion gene LRP1 SNRNP25 drives invasion and migration by activating the pJNK/37LRP/MMP2 signaling pathway in osteosarcoma - Nature
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Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition - Journal of Neuroscience
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CD44s-activated tPA/LRP1-NFκB pathway drives lamellipodia outgrowth in luminal-type breast cancer cells - Frontiers
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Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ - Nature
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This Nanotechnology Discovery Is Reversing Alzheimer's In Mice - bgr.com
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Ligand Binding to LRP1 Transactivates Trk Receptors by a Src Family Kinase–Dependent Pathway - Science | AAAS
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Inhibition of tau neuronal internalization using anti-tau single domain antibodies - Nature
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Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor - Frontiers
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Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis—Brief Report - American Heart Association Journals
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Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling - Wiley
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The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors - Nature
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Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice - Nature
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Yes-Associated Protein (YAP) Promotes Tumorigenesis in Melanoma Cells Through Stimulation of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) - Nature
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LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action - American Physiological Society Journal
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Schematic presentation of the CRISPR/Cas9-Knock out screen. - PLOS
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LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation - American Heart Association Journals
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Schwann Cell LRP1 Regulates Remak Bundle Ultrastructure and Axonal Interactions to Prevent Neuropathic Pain - Journal of Neuroscience
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Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism - Springer Nature Link
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Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1 - Frontiers
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Low density lipoprotein receptor related protein 1 regulates adult hippocampal neurogenesis and memory - Wiley
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Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A - Rockefeller University Press
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LRP-1-mediated intracellular antibody delivery to the Central Nervous System - Nature
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Low-Density Lipoprotein Receptor-Related Protein-1 Signaling in Angiogenesis - Frontiers
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Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1 - Journal of Neuroscience
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Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye - Frontiers
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Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain - Journal of Neuroscience
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Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus - Nature
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The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease - Frontiers
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LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit | Scientific Reports - Nature
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Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption - Rockefeller University Press
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Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9 - ACS Publications
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Functional Roles of the Interaction of APP and Lipoprotein Receptors - Frontiers
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Blocking cellular receptor stops spread of tau in mouse brains - National Institutes of Health (.gov)
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The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells - Nature
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Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration - Journal of Neuroscience
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The Unfolded Protein Response Is a Major Mechanism by Which LRP1 Regulates Schwann Cell Survival after Injury - Journal of Neuroscience
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LRP1 is required for novobiocin-mediated fibronectin turnover - Nature
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Activated α2-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Müller Glial Cells | Scientific Reports - Nature
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Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting - Wiley Online Library
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Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain - Journal of Neuroscience
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Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency - Nature
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New study reveals LRP1's crucial role in bone formation and joint development - News-Medical
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Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1 - Nature
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TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1 | Scientific Reports - Nature
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Dengue virus reduces expression of low-density lipoprotein receptor-related protein 1 to facilitate replication in Aedes aegypti - Nature
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LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease - Frontiers
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Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts - Chun - 2022 - Journal of Thrombosis and Haemostasis - Wiley Online Library
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On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias - Science | AAAS
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416 LRP1 as a modulator of hippocampal neurogenesis and neurodegeneration - Cambridge University Press & Assessment
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Natural killer cells promote intra‐cellular‐infected trophoblasts survival via APOD‐LRP1 axis - Wiley Online Library
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Association of Low-Density Lipoprotein Receptor-Related Protein 1 and Its rs1799986 Polymorphism With Mild Cognitive Impairment in Chinese Patients With Type 2 Diabetes - Frontiers
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Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities - Wiley Online Library
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How the tumor microenvironment stimulates pancreatic cancer growth and progression - Medical Xpress
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Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function - Wiley Online Library
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A bioinformatic approach to characterize the vitellogenin receptor and the low density lipoprotein receptor superfamily in the newt Cynops orientalis - Nature
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LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β - Journal of Neuroscience
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When Alzheimer’s Tau Knocks, This Neuron Receptor Opens the Door - Genetic Engineering and Biotechnology News
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LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis - Science | AAAS
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Blocking cellular receptor stops spread of tau in mouse brains - National Institute on Aging (.gov)
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Tracking Tau - UC Santa Barbara
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Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1 - Nature
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Expression of LRP1 by Human Osteoblasts: A Mechanism for the Delivery of Lipoproteins and Vitamin K1 to Bone - Wiley Online Library
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Mayo Clinic researcher's memory study leads to surprising obesity finding - The Florida Times-Union
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Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1? - Nature
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Mechanism of caveolae-mediated endocytosis of LRP1 - u-tokyo.ac.jp
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CD91 receptor promotes SARS-CoV-2 infection - News-Medical
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Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons - Nature
Why This Topic Is Trending
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