Why is "Leucine" trending?

Search Interest Perspective

• Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature
• How Leucine Supports Muscle Health and Other Health Benefits - Verywell Health
• Understanding Leucine: A Muscle-Building Amino Acid - Cleveland Clinic Health Essentials
• N-Acetyl-L-Leucine Reduces Disease Progression in Phase 2 Extension Study for Ataxia-Telangiectasia - NeurologyLive
• Leucine Zipper 4 Autoantibody–Associated Myeloneuropathy With Multiple Cranial Neuropathies and Longitudinally Extensive Tractopathy - Neurology® Journals
• Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice - Science | AAAS
• Impact of keto leucine and isoleucine on CHO cell central carbon metabolism and performance in fed-batch and steady-state perfusion - Frontiers
• Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum - ScienceDirect.com
• From food to fuel: How leucine enhances mitochondrial energy production - EurekAlert!
• How to Take Leucine for Bodybuilding - Everyday Health
• Scientists discover the nutrient that supercharges cellular energy - ScienceDaily
• Leucine-Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages - Wiley
• N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson’s disease models - JCI.org
• A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1’s role in ap2-g activation - Nature
• Disease-Modifying, Neuroprotective Effect of N-Acetyl-l-Leucine in Adult and Pediatric Patients With Niemann-Pick Disease Type C - Neurology® Journals
• Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport - Frontiers
• Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance | Signal Transduction and Targeted Therapy - Nature
• Leucine Zipper 4 Autoantibody–Associated Myeloneuropathy With Multiple Cranial Neuropathies and Longitudinally Extensive Tractopathy - Neurology® Journals
• Limited therapeutic efficacy of N -acetyl-L-leucine in a mouse model of CLN1 disease - Nature
• GNC launches new leucine-rich GNC AMP Wheybolic - Nutraceutical Business Review
• Utility of Small Bowel Capsule Endoscopy and Leucine-Rich Alpha-2-Glycoprotein in Pediatric Crohn’s Disease Management - Cureus
• HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity - Nature
• Cetobacterium alleviates the lipid accumulation in Nile tilapia (Oreochromis niloticus) induced by leucine addition - Frontiers
• Registered Dietitian Says This Amino Acid Is the “On Switch” for Muscle Growth - Men's Journal
• Exercise and L-leucine supplementation may improve appetite control: Study - nutraingredients.com
• Leucine-rich repeat neuronal 1 as a prognostic indicator and functional modulator in breast cancer - Frontiers
• I’m a trainer, and these are the 11 foods high in leucine I always recommend - The Manual
• Why You Need Valine and How to Get Enough of This BCAA - Verywell Health
• In silico prediction method for plant Nucleotide-binding leucine-rich repeat- and pathogen effector interactions - Wiley Online Library
• The diagnostic utility of urinary 5-HIAA and leucine-rich alpha-2 glycoprotein in acute appendicitis: a narrative review - Frontiers
• Leucine rich repeat containing 15 promotes triple-negative breast cancer proliferation and invasion via the ITGB1/FAK/PI3K signalling pathway - Nature
• GNC Overhauls Wheybolic Line With New Leucine Formula - Store Brands
• Conserved leucine-rich repeat proteins in the adhesive projectile slime of velvet worms - PNAS
• Protein rules that actually matter - keysnews.com
• Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk - Nature
• Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins - Science | AAAS
• Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine - Science | AAAS
• Trial of N -Acetyl- l -Leucine in Niemann–Pick Disease Type C - The New England Journal of Medicine
• The impact of leucine supplementation on body composition and glucose tolerance following energy restriction: an 8-week RCT in adults at risk of the metabolic syndrome - Nature
• -leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports - Nature
• Co-ingestion of glutamine and leucine synergistically promotes mTORC1 activation - Nature
• Low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli - Nature
• Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats - Nature
• Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway - Science | AAAS
• Acetylation turns leucine into a drug by membrane transporter switching - Nature
• Effect of 8-week leucine supplementation and resistance exercise training on muscle hypertrophy and satellite cell activation in rats - Wiley
• Low On Protein? Prioritize Leucine - USA Triathlon
• Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway - Nature
• SAR1B senses leucine levels to regulate mTORC1 signalling - Nature
• Leucine regulates autophagy via acetylation of the mTORC1 component raptor - Nature
• N -Acetyl- l -Leucine and Neurodegenerative Disease - The New England Journal of Medicine
• Should You Take Amino Acid Supplements? - Time Magazine
• Many vegans get enough protein but fall short on key amino acids - News-Medical
• Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila - Nature
• Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling - Nature
• Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency - Nature
• Indirect activation of a plant nucleotide binding site–leucine-rich repeat protein by a bacterial protease - PNAS
• O -GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine - Nature
• Leucine-rich repeat extensin proteins regulate plant salt tolerance in Arabidopsis - PNAS
• Study identifies molecule that stimulates muscle-building - Illinois News Bureau
• LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer - Nature
• Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction - Nature
• A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets - Nature
• Leucine-rich Alpha-2 glycoprotein could be clinically useful in active and postoperative Crohn’s disease - Nature
• N-Acetyl-l-Leucine Significantly Reduces Neurologic Signs and Symptoms in Phase 3 Trial for Niemann-Pick Disease Type C - NeurologyLive
• Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes - Nature
• Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment - Nature
• Quinone perception in plants via leucine-rich-repeat receptor-like kinases - Nature
• Escherichia coli Leucine-Responsive Regulatory Protein Bridges DNA In Vivo and Tunably Dissociates in the Presence of Exogenous Leucine - ASM Journals
• Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors - Nature
• Vegan diets often lack 2 essential amino acids, study finds - South China Morning Post
• Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle - Frontiers
• Leucine-rich alpha-2 glycoprotein as a marker of mucosal healing in inflammatory bowel disease - Nature
• A high-fat diet promotes cancer progression by inducing gut microbiota–mediated leucine production and PMN-MDSC differentiation - PNAS
• Structure and regulation of full-length human leucine-rich repeat kinase 1 - Nature
• Exercise May Promote Skeletal Muscle Hypertrophy via Enhancing Leucine-Sensing: Preliminary Evidence - Frontiers
• Researchers Warn: Vegan Diets May Lack Key Nutrients - SciTechDaily
• Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2 - Science | AAAS
• The role of leucine and isoleucine in tuning the hydropathy of class A GPCRs - Wiley Online Library
• Impacts of protein quantity and distribution on body composition - Frontiers
• Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene - PNAS
• ATP sulfurylase atypical leucine zipper interacts with Cys3 and calcineurin A in the regulation of sulfur amino acid biosynthesis in Cryptococcus neoformans | Scientific Reports - Nature
• Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice - Nature
• Association of leucine and other branched chain amino acids with clinical outcomes in malnourished inpatients: a secondary analysis of the randomized clinical trial EFFORT - Nature
• Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice - Nature
• Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice - Nature
• Differential regulation of mTORC1 by leucine and glutamine - Science | AAAS
• BugSpeaks launches enhanced 2026 gut microbiome report - ET HealthWorld
• Sleep Disorders in Leucine-Rich Glioma-Inactivated Protein 1 and Contactin Protein-Like 2 Antibody-Associated Diseases - Frontiers
• You're Not Getting The Most Out Of Your Protein If It's Lacking This - mindbodygreen.com
• Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration - Nature
• NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway - Nature
• The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells - PNAS
• Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain - PNAS
• Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions - PNAS
• A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival - Frontiers
• An extracellular network of Arabidopsis leucine-rich repeat receptor kinases - Nature
• GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism - Nature
• Even protein-rich vegan diets may fall short on key nutrients, study suggests - BBC Science Focus Magazine
• Effects of dietary L-leucine supplementation on testicular development and semen quality in boars - Frontiers