Why is "Melanocortin 1 receptor" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-24 12:31:15
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Melanocortin_1_receptor entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-24 and was most recently seen on 2026-03-24.
Wikipedia Overview
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH). It is coupled to Gαs and upregulates levels of cAMP by activating adenylyl cyclase in cells expressing this receptor. It is normally expressed in skin and melanocytes, and to a lesser degree in periaqueductal gray matter, astrocytes and leukocytes. In skin cancer, MC1R is highly expressed in melanomas but not carcinomas.
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Trending Topic Today
Search Interest Perspective
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Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity - Nature
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Small-Animal PET of Melanocortin 1 Receptor Expression Using a - Journal of Nuclear Medicine
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Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling - American Heart Association Journals
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Study finds link between red hair and pain threshold - National Institutes of Health (NIH) | (.gov)
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Journal of the European Academy of Dermatology and Venereology - Wiley Online Library
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Red Hair Pigment and Melanoma Risk - The Dermatology Digest
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Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair - The Lancet
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Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy - Nature
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Studies in Mice Help to Explain Why Redheads Have Different Pain Thresholds - Genetic Engineering and Biotechnology News
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Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E - American Heart Association Journals
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Palatin Announces Positive Topline Results from Phase 2 Ulcerative Colitis (UC) Study of Oral Melanocortin-1 Receptor Agonist PL8177 - PR Newswire
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Redheads May Have Different Pain Thresholds – New Research Reveals Why - SciTechDaily
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Redheads and Anesthesia: Do They Feel Pain at Higher Levels? - Healthline
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Functional divergence of the pigmentation gene melanocortin-1 receptor ( MC1R ) in six endemic Macaca species on Sulawesi Island - Nature
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Association of melanocortin 1 receptor gene ( MC1R ) polymorphisms with skin reflectance and freckles in Japanese - Nature
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cAMP-independent non-pigmentary actions of variant melanocortin 1 receptor: AKT-mediated activation of protective responses to oxidative DNA damage - Nature
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Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker - Nature
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Human melanocortin 1 receptor ( MC1R ) gene variants alter melanoma cell growth and adhesion to extracellular matrix - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.