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Mesaconitine (MA) is a highly toxic diterpene, or diester-diterpene alkaloid from plants of the genus Aconitum. It stimulates β-adrenergic receptors, and the consequent activation of intracellular processes can lead to the long-lasting changes in excitability, which in turn leads to disruption of the heart, nerves, and muscles. Hyperexcitability is primarily due to the direct and powerful effect of mesaconitine on voltage-dependent sodium channels in the membranes of excitable cells.
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