Why is "Metallothionein" trending?
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- Date: 2026-04-06 20:06:30
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Metallothionein (MT) is a family of cysteine-rich, low molecular weight proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological and xenobiotic heavy metals through the thiol group of its cysteine residues, which represent nearly 30% of its constituent amino acid residues.
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Search Interest Perspective
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Emerging Roles of Metallothioneins in Human Pathophysiology: A Review - Wiley Online Library
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A review on metallothionein research in marine and estuarine realms: past paradigms and future vistas - Frontiers
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New insights into the role of metallothioneins in obesity and diabetes - Nature
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Metallothionein III Mediates Ca2+-Dependent Zn2+ Spikes to Inhibit Dendritic Arborization - Journal of Neuroscience
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Metallothionein 1: the Achilles heel of Dnmt3a;Npm1-mutant acute myeloid leukemia - Haematologica
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Single-Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein-Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease - Wiley
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The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway - Nature
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A nutritional epigenetics study protocol indicates changes in prenatal ultra-processed food intake may reduce lead and mercury exposures to prevent autism and ADHD - EurekAlert!
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Zinc metallothionein imported into liver mitochondria modulates respiration - PNAS
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Characteristics, functions, and applications of metallothionein in aquatic vertebrates - Frontiers
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Cadmium tolerance is associated with tissue-specific plasticity of metallothionein gene expression in Gammarus fossarum field populations - Nature
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Metallothionein family genes in kiwifruit: characterization and determining their roles in plant’s response to different stresses - Frontiers
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A multi-domain snail metallothionein increases cadmium resistance and fitness in Caenorhabditis elegans - Nature
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Single-cell RNA sequencing data identify a conserved population of metallothionein-expressing macrophages that may be ubiquitous in vital human organs - Wiley Online Library
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Metallothionein 1: A New Spotlight on Inflammatory Diseases - Frontiers
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Acute toxicity of mercury in response to metallothionein expression and oxidative and cellular metabolic stress in Barbonymus gonionotus - Nature
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Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma - Nature
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Unique expression and critical role of metallothionein 3 in the control of osteoclastogenesis and osteoporosis - Nature
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Ultra-processed foods linked to prenatal heavy metal exposure and child brain development - Medical Xpress
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Metallothionein immunohistochemistry has high sensitivity and specificity for detection of Wilson disease - Nature
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Metallothionein 3 promotes osteoclast differentiation and survival by regulating the intracellular Zn - Nature
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Comparative analysis of immunomodulatory biomarker responses in clams Meretrix meretrix and Mactra veneriformis to waterborne cadmium exposure - Frontiers
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Functional characterization of a type 2 metallothionein gene, SsMT2 , from alkaline-tolerant Suaeda salsa - Nature
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A novel built-in adjuvant metallothionein-3 aids protein antigens to induce rapid, robust, and durable immune responses - Frontiers
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Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma - Nature
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Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease - Frontiers
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AP-1 (bZIP) Transcription Factors as Potential Regulators of Metallothionein Gene Expression in Tetrahymena thermophila - Frontiers
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The role of metallothionein in a dinitrofluorobenzene-induced atopic dermatitis-like murine model - Nature
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Microalgal Metallothioneins and Phytochelatins and Their Potential Use in Bioremediation - Frontiers
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Metallothionein: a game changer in histopathological diagnosis of Wilson disease - Wiley Online Library
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Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese - Nature
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Metallothionein-3-mediated intracellular zinc mediates antioxidant and anti-inflammatory responses in the complete Freund’s adjuvant-induced inflammatory pain mouse model - Nature
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Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies - Frontiers
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ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma - Nature
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Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival - Nature
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A role of metallothionein-3 in radiation-induced autophagy in glioma cells - Nature
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Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule - Science Partner Journals
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A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma - Nature
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Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis - Nature
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AzuR From the SmtB/ArsR Family of Transcriptional Repressors Regulates Metallothionein in Anabaena sp. Strain PCC 7120 - Frontiers
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Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans | Scientific Reports - Nature
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Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein - Nature
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Engineering a mouse metallothionein on the cell surface of Ralstonia eutropha CH34 for immobilization of heavy metals in soil - Nature
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Prevention of gastrointestinal lead poisoning using recombinant Lactococcus lactis expressing human metallothionein-I fusion protein - Nature
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Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess - Nature
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Changes in physio-biochemical parameters and expression of metallothioneins in Avena sativa L. in response to drought - Nature
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Macrophage metallothioneins participate in the antileishmanial activity of antimonials - Frontiers
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Zinc chelation: a metallothionein 2A’s mechanism of action involved in osteosarcoma cell death and chemotherapy resistance - Nature
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Evidence for nuclear interaction of a cytoskeleton protein (OsIFL) with metallothionein and its role in salinity stress tolerance - Nature
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Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex - ScienceDirect.com
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Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes - American Physiological Society Journal
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Differential protein expression in metallothionein protection from depleted uranium-induced nephrotoxicity - Nature
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A de novo evolved domain improves the cadmium detoxification capacity of limpet metallothioneins - Nature
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Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice - Wiley Online Library
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Effects of Waterborne Cadmium Exposure on Its Internal Distribution in Meretrix meretrix and Detoxification by Metallothionein and Antioxidant Enzymes - Frontiers
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Molecular Medicine Reports - Spandidos Publications
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Quantitative Plasma Proteomics Identifies Metallothioneins as a Marker of Acute-on-Chronic Liver Failure Associated Acute Kidney Injury - medRxiv
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Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells - Wiley Online Library
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Biofilm and metallothioneins: A dual approach to bioremediate the heavy metal menace - Wiley Online Library
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The Glutathione/Metallothionein System Challenges the Design of Efficient O2‐Activating Copper Complexes - Wiley Online Library
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Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent - Nature
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Engineered Bacteria EcN-MT Alleviate Liver Injury in Cadmium-Exposed Mice via its Probiotics Characteristics and Expressing of Metallothionein - Frontiers
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UConn, Biohaven Pharmaceuticals Ink Licensing Deal for Investigational Agent for Inflammatory and Autoimmune Diseases - UConn Today
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Intracellular bioaccumulation of the rare earth element Gadolinium in ciliate cells resulting in biogenic particle formation and excretion - Nature
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Distinct pathways for zinc metabolism in the terrestrial slug Arion vulgaris - Nature
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Cilostazol restores autophagy flux in bafilomycin A1-treated, cultured cortical astrocytes through lysosomal reacidification: roles of PKA, zinc and metallothionein 3 - Nature
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Toxicological effects of copper on bioaccumulation and mRNA expression of antioxidant, immune, and apoptosis-related genes in Chinese striped-necked turtle ( Mauremys sinensis - Frontiers
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The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression - Nature
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Zinc and the modulation of redox homeostasis - ScienceDirect.com
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PmtA Regulates Pyocyanin Expression and Biofilm Formation in Pseudomonas aeruginosa - Frontiers
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Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors - Nature
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SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression | Oncogenesis - Nature
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ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins - Frontiers
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Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd3S9 | Scientific Reports - Nature
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Identification and functional analysis of cadmium-binding protein in the visceral mass of Crassostrea gigas - Nature
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Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - Nature
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Hydrogen sulfide - cysteine cycle system enhances cadmium tolerance through alleviating cadmium-induced oxidative stress and ion toxicity in Arabidopsis roots - Nature
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Use of molecular biomarkers in Eisenia foetida to assess copper toxicity in agricultural soils affected by mining activities - Scielo.cl
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Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein - Nature
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Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.