Why is "Mineralocorticoids" trending?
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Trend Analysis
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- Date: 2026-03-18 04:59:47
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Wikipedia Overview
Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. Mineralocorticoids are produced in the adrenal cortex and influence salt and water balances. The primary mineralocorticoid is aldosterone.
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Search Interest Perspective
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Aldosterone and the Mineralocorticoid Receptor in Atrial Fibrillation - American Heart Association Journals
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Aldosterone-mediated hypertension and non-steroidal mineralocorticoid receptor antagonists - Nature
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Could Mineralocorticoid Receptor Antagonists Be Harmful in Some Patients With Heart Failure? - JACC Journals
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Safety and efficacy of steroidal mineralocorticoid receptor antagonists in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of randomised controlled trials - The Lancet
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Steroidal mineralocorticoid receptor antagonists show little mortality benefit in patients receiving dialysis - 2 Minute Medicine
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Recent advances in mineralocorticoid receptor antagonists for heart failure with preserved ejection fraction: focus on finerenone in the era of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists - Frontiers
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[Figure, Steroid Hormone Synthesis Pathways from...] - StatPearls - National Institutes of Health (.gov)
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Mineralocorticoid Blocker Gets EU Nod for Heart Failure - Medscape
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Pharmacology and Therapeutic Potential of Finerenone: A Novel Third-Generation Nonsteroidal Mineralocorticoid Receptor Antagonist - Cureus
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Aldosterone–mineralocorticoid receptor interactions: new insights and therapeutic perspectives in primary aldosteronism - Nature
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Finerenone improves albuminuria in adults with type 1 diabetes and chronic kidney disease - 2 Minute Medicine
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Heart Failure: Use of MRAs for HFmrEF and HFpEF - Medscape Reference
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Mineralocorticoid antagonism in the treatment of heart failure - Nature
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Mineralocorticoid and glucocorticoid receptor heterodimers mediate cortisol-induced behavioural changes via modulation of glutamatergic signalling - Nature
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Positioning esaxerenone, a non-steroidal mineralocorticoid receptor antagonist, in the treatment of hypertension with and without hemodynamic cardiac stress - Nature
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Perirenal fat: a missing link between mineralocorticoid receptor activation and cardiovascular-kidney-metabolic syndrome in primary aldosteronism | Hypertension Research - Nature
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Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1 - Nature
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Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models - Nature
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Mineralocorticoid receptor phase separation modulates cardiac preservation - Nature
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Comparing the Long-Term Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors Versus Mineralocorticoid Receptor Antagonists as Add-On Therapies in the Management of Heart Failure: A Systematic Review - Cureus
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Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post‐Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest - American Heart Association Journals
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Mineralocorticoid receptor antagonists in heart failure: a systematic review and meta-analysis - Frontiers
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Mineralocorticoid Receptor Antagonist Use in Hypertension to Prevent Heart Failure: - JACC Journals
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A systematic review to compare adrenalectomy and mineralocorticoid receptor antagonists in patients with unilateral primary aldosteronism - Nature
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Blood pressure response to mineralocorticoid receptor antagonists or aldosterone synthase inhibitors according to baseline renin levels - Nature
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Glucocorticoids and mineralocorticoids in hair: facilitating accurate diagnosis of adrenal-related endocrine disorders - Frontiers
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E-Cigarette Smoke Exposure Elevates Renal MR Expression and Induces BP Elevation - American Heart Association Journals
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Stable-isotope tracing reveals the role of corticosteroid receptors in driving cortisol-mediated central and peripheral glucose regulation in zebrafish - Frontiers
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Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis - The Lancet
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Mineralocorticoid Receptors: - American Heart Association Journals
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Combining Semaglutide and Mineralocorticoids May Improve CKD - Medscape
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Characteristic analysis of adverse reactions of finerenone: an in-depth analysis from WHO-VigiAccess - Frontiers
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Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water - Nature
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The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor - PNAS
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Mineralocorticoid receptor overactivation in diabetes mellitus: role of O -GlcNAc modification - Nature
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Screen All With Hypertension for Primary Aldosteronism - Medscape
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Subtype Identification of Surgically Curable Primary Aldosteronism During Treatment With Mineralocorticoid Receptor Blockade - American Heart Association Journals
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Mineralocorticoid Effects in Cushing’s Disease: A Case Report - Cureus
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Arterial NALCN Knockdown Ameliorates Mineralocorticoid-Induced Hypertension and Arterial Overcontractility - American Heart Association Journals
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Visceral fat: a bad companion for mineralocorticoid receptor overactivation - Nature
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Mineralocorticoid Receptor Antagonism Prevents Aortic Plaque Progression and Reduces Left Ventricular Mass and Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease: The MAGMA Trial | Circulation - American Heart Association Journals
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Multiplexed steroid profiling of gluco- and mineralocorticoids pathways using a liquid chromatography tandem mass spectrometry method - ScienceDirect.com
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Prediction of endogenous mineralocorticoid receptor activity by depressor effects of mineralocorticoid receptor antagonists in patients with primary aldosteronism - Nature
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Esaxerenone Shows Cardiometabolic Benefits for Hypertension, T2D - Drug Topics
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Mineralocorticoid receptor antagonists in diabetic kidney disease — mechanistic and therapeutic effects - Nature
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Posttranslational Modifications of the Mineralocorticoid Receptor and Cardiovascular Aging - Frontiers
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A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids - Nature
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Novel role for mineralocorticoid receptors in control of a neuronal phenotype - Nature
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Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism - Nature
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Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis - American Heart Association Journals
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Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice | Neuropsychopharmacology - Nature
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Mineralocorticoid receptor antagonists for every patient with heart failure - The Lancet
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Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia | Circulation Research - American Heart Association Journals
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Association and mediation analyses among multiple metal exposure, mineralocorticoid levels, and serum ion balance in residents of northwest China - Nature
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Blocking mineralocorticoid signaling with esaxerenone reduces atherosclerosis in hyperglycemic ApoE KO mice without affecting blood pressure and glycolipid metabolism - Nature
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Structural determinants of activation of the mineralocorticoid receptor: an evolutionary perspective - Nature
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Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis - Frontiers
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Aldosterone and Vascular Mineralocorticoid Receptors: - American Heart Association Journals
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Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess - Nature
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ACHIEVE: Spironolactone Fails to Reduce Cardiovascular Risk in Dialysis Patients - HCPLive
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Efficacy and safety of mineralocorticoid receptor antagonists for the treatment of low-renin hypertension: a systematic review and meta-analysis - Nature
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A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse - American Heart Association Journals
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Spironolactone Fails to Cut Serious Cardiac Events in End-Stage Kidney Disease - MedPage Today
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Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate | Prostate Cancer and Prostatic Diseases - Nature
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Cardiac Mineralocorticoid Receptor and the Na+/H+ Exchanger: Spilling the Beans - Frontiers
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Mineralocorticoid receptor blockers for moderate kidney dysfunction: more merit than ever? | Hypertension Research - Nature
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Effects of esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, independent of urinary sodium/potassium ratio and salt intake - Nature
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New target may help protect bones as we age - Augusta University News
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Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease - Nature
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Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension: Insights from basic research - Frontiers
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Does mineralocorticoid receptor play a vital role in the development of depressive disorder? - ScienceDirect.com
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Effects of mineralocorticoid receptor antagonists on sex hormones and body composition in patients with primary aldosteronism - Nature
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The Cardiac Mineralocorticoid Receptor (MR): A Therapeutic Target Against Ventricular Arrhythmias - Frontiers
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Emerging fields for therapeutic targeting of the aldosterone–mineralocorticoid receptor signaling pathway - British Pharmacological Society | Journals
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Mineralocorticoid receptor as a therapeutic target in chronic kidney disease and hypertension - Nature
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Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation - Nature
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Identifying new cellular mechanisms of mineralocorticoid receptor activation in the heart - Nature
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Membrane Associated Synaptic Mineralocorticoid and Glucocorticoid Receptors Are Rapid Regulators of Dendritic Spines - Frontiers
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Comparison of echocardiographic findings in patients with aldosterone-producing adenomas: adrenalectomy versus mineralocorticoid receptor antagonists - Nature
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Association of Mineralocorticoid Receptor Antagonists With the Mortality and Cardiovascular Effects in Dialysis Patients: A Meta-analysis - Frontiers
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Aldosterone Synthase Inhibitors and Mineralocorticoid Receptor Antagonists: Competitors or Collaborators? - American Heart Association Journals
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MRAs, SGLT2 Inhibitors, and Kidney Outcomes in CKD and HF: Differences in Diseases, Drugs, or Both? - JACC Journals
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Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study | Hypertension Research - Nature
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Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension? - Frontiers
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Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma - Nature
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Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure - American Heart Association Journals
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Predictive factors of selective mineralocorticoid receptor antagonist treatment in chronic central serous chorioretinopathy - Nature
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Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification - Nature
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Treatment with a mineralocorticoid receptor blocker esaxerenone on top of the first-line therapy: promise in uncontrolled hypertension - Nature
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Efficacy of esaxerenone—a nonsteroidal mineralocorticoid receptor blocker—on nocturnal hypertension - Nature
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Non-steroidal mineralocorticoid receptor antagonists in heart failure - Nature
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Glucocorticoid and mineralocorticoid receptor expression in critical illness: A narrative review - Baishideng Publishing Group
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Mineralocorticoid receptor antagonists for cardioprotection in chronic kidney disease: a step into the future - Nature
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A comprehensive review of finerenone—a third-generation non-steroidal mineralocorticoid receptor antagonist - Frontiers
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Mineralocorticoids show utility as type 2 diabetes, prediabetes biomarkers - Healio
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CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity - Nature
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Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling - Nature
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Systematic review of the clinical outcomes of mineralocorticoid receptor antagonist treatment versus adrenalectomy in patients with primary aldosteronism - Nature
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Mineralocorticoid Receptor Stimulation Improves Cognitive Function and Decreases Cortisol Secretion in Depressed Patients and Healthy Individuals - Nature
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Blocking Mineralocorticoid Receptors Preserves Kidney Function in Diabetes - Inside Precision Medicine
Why This Topic Is Trending
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.