Why is "Mitophagy" trending?

Search Interest Perspective

• Mitophagy in the pathogenesis and management of disease - Nature
• Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway - PNAS
• Receptor-mediated mitophagy: a new target of neurodegenerative diseases - Frontiers
• Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress - Science | AAAS
• Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis - Rockefeller University Press
• Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
• USP25 inhibition ameliorates Parkinson’s disease by restoring mitophagy - PNAS
• Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration - Frontiers
• Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging - Nature
• Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies - Nature
• A mitochondria-targeted fluoropolymer nanoparticle with inherent mitophagy-inducing and red fluorescence properties for treatment of atherosclerosis - Nature
• Recovery from apoptosis in photoreceptor cells: A role for mitophagy - Cell Death & Disease - Nature
• Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature
• Exploring mitophagy levels in Drosophila Malpighian tubules unveils the pivotal role of mitophagy in kidney function and diabetic kidney disease - Nature
• ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis - Nature
• Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature
• Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation - Nature
• Arachidonic acid induces pyroptosis via a non-autophagic function of mitophagy and enhances immunotherapy in a PDAC model - Nature
• Ubiquitin-specific protease 14 inhibition promotes mitophagy and attenuates neural apoptosis after spinal cord injury - Nature
• Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy - Nature
• The role of mitophagy in female reproductive system diseases: from molecular mechanisms to therapeutic strategies - Frontiers
• STAR/STARD1: A mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy - PNAS
• Targeting FAM111B attenuates mitophagy and increases the sensitivity to lenvatinib treatment by increasing MFN2 stability in hepatocellular carcinoma - Nature
• DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species - Nature
• An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates - Nature
• PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning - Nature
• Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy - American Heart Association Journals
• USP30 inhibition augments mitophagy to prevent T cell exhaustion - Science | AAAS
• Mitophagy in the mechanisms of treatment resistance in solid tumors - Frontiers
• The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria - Rockefeller University Press
• Macrophage mitophagy-related genes predict prognosis and therapeutic response in lung adenocarcinoma - Nature
• Porcine deltacoronavirus infection triggers mitophagy to dampen the interferon response and promote viral replication - Frontiers
• Targeting MCL1 by UMI-77 to induce mitophagy alleviates renal tubular epithelial cells injury in acute kidney injury - Nature
• RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer | Oncogene - Nature
• A structural switch reveals how to disarm USP30 and unlock mitophagy - Nature
• Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells - Frontiers
• Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury - Frontiers
• CaM promotes cardiomyocyte mitophagy in myocardial ischemia-reperfusion injury involving in the regulation of the IP3R3-GRP75-VDAC1 complex - Nature
• Isoliensinine inhibits mitophagy and sensitizes T cell malignancies for STING-mediated NK clearance - Nature
• Identification of biomarkers associated with mitophagy in bladder cancer - Nature
• Evidence that mitochondria in macrophages are destroyed by microautophagy - Nature
• Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature
• Sex and region-specific disruption of autophagy and mitophagy in Alzheimer’s disease: linking cellular dysfunction to cognitive decline - Nature
• NIA Small Business Showcase: Vincere Biosciences - National Institute on Aging (.gov)
• The mitophagy pathway and its implications in human diseases | Signal Transduction and Targeted Therapy - Nature
• Mitophagy-related regulated cell death: molecular mechanisms and disease implications - Nature
• Mitophagy in human health, ageing and disease - Nature
• The Role of Mitophagy in Innate Immunity - Frontiers
• Targeting mitophagy in neurodegenerative diseases - Nature
• Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD - Nature
• Mitophagy in ischemic heart disease: molecular mechanisms and clinical management - Nature
• Mechanism and role of mitophagy in the development of severe infection - Nature
• PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy - Nature
• Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature
• Ginsenoside Rh2 repressed the progression of prostate cancer through the mitochondrial damage induced by mitophagy and ferroptosis - Frontiers
• Leveraging engineered mitochondria through intercellular communication network for accelerated transport and delivery - Nature
• Mitochondrial transfer mediates endothelial cell engraftment through mitophagy - Nature
• Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging - Nature
• Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy - Nature
• Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy | Cell Death & Differentiation - Nature
• Inflammation and mitophagy are mitochondrial checkpoints to aging - Nature
• Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases - Nature
• Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis - Science | AAAS
• MitophAging: Mitophagy in Aging and Disease - Frontiers
• A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy | Cell Discovery - Nature
• Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency - Nature
• Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review - Frontiers
• Mitophagy: insights into its signaling molecules, biological functions, and therapeutic potential in breast cancer - Nature
• Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches - Nature
• BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia - Nature
• Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury - Wiley
• Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8+ T cell formation - Science | AAAS
• Mitochondrial Ca2+ oscillation induces mitophagy initiation through the PINK1-Parkin pathway | Cell Death & Disease - Nature
• CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model - Nature
• The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress - Nature
• Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes - Nature
• Coronavirus M protein promotes mitophagy over virophagy by recruiting PDPK1 to phosphorylate SQSTM1 at T138 - Nature
• Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy - Nature
• BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma - Nature
• SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia | Cell Death & Disease - Nature
• Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow - Nature
• USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons - Nature
• Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease - Nature
• BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects - Nature
• ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3 - Nature
• augmentation restores mitophagy and limits accelerated aging in Werner syndrome - Nature
• Blood flow meets mitophagy - Rockefeller University Press
• The role of mitophagy in metabolic diseases and its exercise intervention - Frontiers
• Pancreatic β-cell mitophagy as an adaptive response to metabolic stress and the underlying mechanism that involves lysosomal Ca2+ release | Experimental & Molecular Medicine - Nature
• Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model - Nature
• PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease - Nature
• Role of mitophagy in the neurodegenerative diseases and its pharmacological advances: A review - Frontiers
• Mitochondrial Lon-induced mitophagy benefits hypoxic resistance via Ca - Nature
• Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases - Frontiers
• Erastin-induced multi-pathway cell death in endometriosis: a mechanistic and translational narrative review - Frontiers
• HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome - Nature
• Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns - Frontiers
• KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy | Scientific Reports - Nature
• Reversible induction of mitophagy by an optogenetic bimodular system - Nature
• The ketogenic diet and hypoxia promote mitophagy in the context of glaucoma - Frontiers