Why is "Nicotinic acetylcholine receptor" trending?
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- Date: 2026-04-03 05:09:13
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Wikipedia Overview
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system; and (2) they are the receptors found on skeletal muscle that receives acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system.
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Characterisation of an unusual nicotinic acetylcholine receptor subtype preferentially sensitive to biogenic amines - Nature
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Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization - Science | AAAS
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Loss of α7 nicotinic acetylcholine receptor exacerbates adrenergic-induced cardiac damage - American Physiological Society Journal
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Regulation of Melanogenesis in Skin Epidermal Keratinocytes via Activation of α7 Nicotinic Acetylcholine Receptor on the Expression of α-Melanocyte-Stimulating Hormone - Wiley
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α7 nicotinic acetylcholine receptor agonist attenuates lipopolysaccharide-induced acute kidney injury in mice by reducing CCL2 expression in macrophages - Nature
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Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction - Frontiers
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Cloning and Preliminary Functional Studies of the Nicotinic Acetylcholine Receptor α6 Subunit in Megalurothrips usitatus (Bagnall) - Wiley Online Library
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Control of Synaptic Levels of Nicotinic Acetylcholine Receptor by the Sequestering Subunit Dα5 and Secreted Scaffold Protein Hig - Journal of Neuroscience
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The role of the α7 nicotinic acetylcholine receptor in promoting M2 macrophage polarization at inflammatory sites - Nature
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Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging - Journal of Neuroscience
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Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins - Frontiers
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α7 nicotinic acetylcholine receptor, activated glia, and cognitive impairment in schizophrenia: a dual-tracer PET study - Nature
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The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology - Nature
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Nicotine in e-cigarette aerosol reduces GABA neuron migration via the α7 nicotinic acetylcholine receptor - Nature
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Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition - Nature
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An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling - Nature
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Structural basis of human α7 nicotinic acetylcholine receptor activation - Nature
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Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model - Nature
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A release of local subunit conformational heterogeneity underlies gating in a muscle nicotinic acetylcholine receptor - Nature
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Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor - Nature
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Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling - PNAS
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Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence - Nature
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Intracellular complexes of the β2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics - PNAS
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Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor - PNAS
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The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2* and α3β4* Receptors - Frontiers
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Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility - Frontiers
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Alpha-7 nicotinic acetylcholine receptor agonist alleviates psoriasis-like inflammation through inhibition of the STAT3 and NF-κB signaling pathway - Nature
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Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products - PNAS
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High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using 18F-ASEM PET - Journal of Nuclear Medicine
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A nicotinic acetylcholine receptor mutation conferring target-site resistance to imidacloprid in Nilaparvata lugens (brown planthopper) - PNAS
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Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity - Nature
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The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke - Frontiers
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Neurobiologist Jean-Pierre Changeux tells us the story of the nicotinic acetylcholine receptor - Institut Pasteur
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The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass - Nature
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Identification of Nicotinic Acetylcholine Receptor for N-Acetylcysteine to Rescue Nicotine-induced Injury Using Beating Cilia in Primary Tissue Derived Airway Organoids - Wiley
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α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins - Nature
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Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice - Nature
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Target identification and validation of the alpha7 nicotinic acetylcholine receptor as a potential therapeutic target in retinal disease - Frontiers
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Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens - Nature
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The α10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system - PNAS
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Greater Nicotinic Acetylcholine Receptor Density in Smokers Than in Nonsmokers: A PET Study with 2-18F-FA-85380 - Journal of Nuclear Medicine
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Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine - Nature
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Temporal Change in Human Nicotinic Acetylcholine Receptor After Smoking Cessation: 5IA SPECT Study - Journal of Nuclear Medicine
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The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family - Frontiers
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Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane - Nature
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α7 Nicotinic Acetylcholine Receptor May Be a Pharmacological Target for Perioperative Neurocognitive Disorders - Frontiers
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Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex - Nature
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An in vitro potency assay using nicotinic acetylcholine receptor binding works well with antivenoms against Bungarus candidus and Naja naja - Nature
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Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p -AKT/Bcl-2 pathways - Nature
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The expression of nicotinic acetylcholine receptor subunits and their associations with local immune cells and prognosis in oral squamous cell carcinoma - Wiley Online Library
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A gating mechanism proposed from a simulation of a human α7 nicotinic acetylcholine receptor - PNAS
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Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology - Nature
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Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease - ScienceDirect.com
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Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain - PNAS
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Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption - Frontiers
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Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies | Scientific Reports - Nature
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The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests | Scientific Reports - Nature
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Crystallization scale purification of α7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system - Nature
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18F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET - Journal of Nuclear Medicine
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State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor - Nature
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AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats | Neuropsychopharmacology - Nature
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Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis - Frontiers
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Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression - Nature
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The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein - Frontiers
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Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor - Nature
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Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder - Frontiers
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Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking - PNAS
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A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization - Journal of Neuroscience
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Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress - Nature
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High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice - ScienceDirect.com
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Nicotinic Acetylcholine Receptor β2 Subunits in the Medial Prefrontal Cortex Control Attention - Science | AAAS
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Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice - Frontiers
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Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2 - Nature
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Loss of α-9 Nicotinic Acetylcholine Receptor Subunit Predominantly Results in Impaired Postural Stability Rather Than Gaze Stability - Frontiers
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Multiple mutations in the nicotinic acetylcholine receptor Ccα6 gene associated with resistance to spinosad in medfly - Nature
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Retinal waves in mice lacking the β2 subunit of the nicotinic acetylcholine receptor - PNAS
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Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke - Frontiers
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Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats - Nature
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Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia - Nature
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Activation of α7 Nicotinic Acetylcholine Receptor Decreases On-site Mortality in Crush Syndrome through Insulin Signaling-Na/K-ATPase Pathway - Frontiers
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Behavioral changes after nicotine challenge are associated with α7 nicotinic acetylcholine receptor-stimulated glutamate release in the rat dorsal striatum - Nature
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Alpha7 nicotinic acetylcholine receptor activation protects against myocardial reperfusion injury through modulation of autophagy - ScienceDirect.com
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α7 Nicotinic Acetylcholine Receptor Is Expressed in Human Atherosclerosis and Inhibits Disease in Mice—Brief Report - American Heart Association Journals
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Nicotinic Acetylcholine Receptor Agonists: A Milestone for Modern Crop Protection - Wiley Online Library
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Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies - Nature
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β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue - Frontiers
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Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia | Neuropsychopharmacology - Nature
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Treatment for Tobacco Dependence: Effect on Brain Nicotinic Acetylcholine Receptor Density - Nature
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Crucial Role of α4 and α6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration - Journal of Neuroscience
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Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy - Wiley Online Library
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Correction: Corrigendum: Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex - Nature
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Differential Desensitization and Distribution of Nicotinic Acetylcholine Receptor Subtypes in Midbrain Dopamine Areas - Journal of Neuroscience
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Nicotine Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells - American Heart Association Journals
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Embedded cholesterol in the nicotinic acetylcholine receptor - PNAS
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The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance via Regulation of Monocyte Recruitment and Activity in Polymicrobial Septic Peritonitis - Frontiers
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Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor - Nature
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Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression - Frontiers
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Nicotinic Acetylcholine Receptor Distribution in Alzheimer's Disease, Dementia with Lewy Bodies, Parkinson's Disease, and Vascular Dementia: In Vitro Binding Study Using 5-[125I]-A-85380 | Neuropsychopharmacology - Nature
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Nicotinic Acetylcholine Receptor Stability at the NMJ Deficient in α-Syntrophin In Vivo - Journal of Neuroscience
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An allosteric link connecting the lipid-protein interface to the gating of the nicotinic acetylcholine receptor - Nature
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