Why is "Parkin (protein)" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-04-06 15:11:13
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PRKN gene. Parkin plays a critical role in ubiquitination – the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes. Ubiquitination involves the sequential action of three enzymes. First, an E1 ubiquitin-activating enzyme binds to inactive Ub in eukaryotic cells via a thioester bond and mobilises it in an ATP-dependent process. Ub is then transferred to an E2 ubiquitin-conjugating enzyme before being conjugated to the target protein via an E3 ubiquitin ligase. There exists a multitude of E3 ligases, which differ in structure and substrate specificity to allow selective targeting of proteins to intracellular degradation.
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Trending Topic Today
Search Interest Perspective
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Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy - Nature
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Early Parkinson's-mutated parkin protein reactivated by 'molecular glue': Study - Parkinson's News Today
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Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? - PNAS
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Researchers identify role of Parkinson's-related protein in cancer and T cell activation - Medical Xpress
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Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover - Journal of Neuroscience
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Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia - Nature
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Parkin protein linked with Parkinson’s disease promotes anti-tumor responses - Parkinson's News Today
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Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy - Nature
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Enzyme Triggers Parkin, Protein With Parkinson's Link, to Protect Cells - Parkinson's News Today
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A mutational atlas for Parkin proteostasis - Nature
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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase - Nature
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Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia - Nature
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DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria - Nature
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PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products - Nature
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Naturally occurring hyperactive variants of human parkin - Communications Biology - Nature
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Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma - Nature
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Activation of parkin by a molecular glue - Nature
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Parkin maintains mitochondrial levels of the protective Parkinson’s disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10 | Cell Death & Differentiation - Nature
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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling - Nature
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A molecular explanation for the recessive nature of parkin -linked Parkinson’s disease - Nature
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The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells - Nature
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Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury - Nature
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PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy - Nature
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Parkin-dependent regulation of the MCU complex component MICU1 - Nature
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Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency - Nature
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The Roles of PINK1 and Parkin in Parkinson's Disease - PLOS
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The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy - Nature
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Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson’s disease model - Nature
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Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function - PNAS
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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases - Nature
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Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress - Nature
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Protein Called MITOL Linked to Parkinson’s, Research Suggests - Parkinson's News Today
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Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover - Journal of Neuroscience
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Parkin regulates kainate receptors by interacting with the GluK2 subunit - Nature
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Selective escape of proteins from the mitochondria during mitophagy - Nature
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Parkinson's disease protein buys time for cell repair - Medical Xpress
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Enhancing protein degradation studies with cell-free E3 ligase expression - News-Medical
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HBV/HBx promotes mitochondrial fission via Drp1 stimulation and activation. - PLOS
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Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease - Nature
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HKDC1 protein found crucial to maintaining two mitochondria subcellular structures, mitochondria and lysosomes - Phys.org
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Tumor Suppressor Parkin Reduces Primary and Metastatic Growth - genengnews.com
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The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo - PNAS
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Parkinson’s disease protein buys time for cell repair - wehi.edu.au
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Early-onset Parkinson's: Novel drug molecule may fight development - Medical News Today
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Getting Parkin going again | The Neuro - McGill University
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