Why is "Phospholipase C" trending?
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Trend Analysis
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- Date: 2026-03-20 12:26:07
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Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Phospholipase C's role in signal transduction is its cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which serve as second messengers. Activators of each PLC vary, but typically include heterotrimeric G protein subunits, protein tyrosine kinases, small G proteins, Ca2+, and phospholipids.
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Search Interest Perspective
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Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability - Science | AAAS
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Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia - Nature
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Phospholipase C: underrated players in microbial infections - Frontiers
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Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation - PNAS
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Putting G protein–coupled receptor-mediated activation of phospholipase C in the limelight - Rockefeller University Press
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Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi - ASM Journals
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Phosphatidylinositol-specific phospholipase C enhances epidermal penetration by Staphylococcus aureus - Nature
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Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors - PNAS
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Genome-Wide Investigation of the Phospholipase C Gene Family in Zea mays - Frontiers
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Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C - Nature
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Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia - Frontiers
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Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction - PNAS
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Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow - Nature
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Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes - Nature
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Functional redundancy of Burkholderia pseudomallei phospholipase C enzymes and their role in virulence - Nature
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Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK - Nature
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A fungal phospholipase C involved in the degradation of plant glycosylinositol phosphorylceramides during Arabidopsis/Botrytis interaction - Nature
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Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling - Nature
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Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice - Nature
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In silico analysis to identify miR-1271-5p/PLCB4 (phospholipase C Beta 4) axis mediated oxaliplatin resistance in metastatic colorectal cancer - Nature
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Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels - PNAS
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Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS - PNAS
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G-protein-activated phospholipase C- β , new partners for cell polarity proteins Par3 and Par6 - Nature
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Japanese Encephalitis Virus Exploits Dopamine D2 Receptor-phospholipase C to Target Dopaminergic Human Neuronal Cells - Frontiers
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Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway - Nature
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Focal adhesion kinase promotes phospholipase C-γ1 activity - PNAS
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–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain - Nature
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Characterization of the Glehnia littoralis Non-specific Phospholipase C Gene GlNPC3 and Its Involvement in the Salt Stress Response - Frontiers
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Neuropeptide S Induces Acute Anxiolysis by Phospholipase C-Dependent Signaling within the Medial Amygdala - Nature
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Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements - Nature
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The Phospholipase C-IP3 Pathway is Involved in Muscarinic Antinociception | Neuropsychopharmacology - Nature
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Dephosphorylation of the adaptor LAT and phospholipase C–γ by SHP-1 inhibits natural killer cell cytotoxicity - Science | AAAS
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Protein Kinase C and Phospholipase C Activity and Expression of Their Specific Isozymes Is Decreased and Expression of MARCKS Is Increased in Platelets of Bipolar but Not in Unipolar Patients - Nature
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Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening - PNAS
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ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways - Nature
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Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer - Nature
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A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase - Nature
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A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq - Nature
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DAF-2c signaling promotes taste avoidance after starvation in Caenorhabditis elegans by controlling distinct phospholipase C isozymes - Nature
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Single and Repeated Stress-Induced Modulation of Phospholipase C Catalytic Activity and Expression: Role in LH Behavior - Nature
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Crystal structure of Rac1 bound to its effector phospholipase C-β2 - Nature
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Phospholipase C isozymes selectively couple to specific neurotransmitter receptors - Nature
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Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm? - Nature
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Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants - Nature
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Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-γ1 - PNAS
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Phospholipase C and termination of G-protein-mediated signalling in vivo - Nature
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Abscisic acid induces oscillations in guard-cell cytosolic free calcium that involve phosphoinositide-specific phospholipase C - PNAS
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Inositide-specific phospholipase c β1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia | Leukemia - Nature
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Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis - Nature
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Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-γ regulated gene negatively associated with prostate tumor invasion - Nature
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Requirement of phospholipase C-γ2 (PLCγ2) for Dectin-1-induced antigen presentation and induction of T - Wiley Online Library
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Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade - Nature
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PLCβ1 by-passes early growth response -1 to induce the differentiation of neuronal cells - Nature
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kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast - ASM Journals
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+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C β4 Signaling Cascade in the Cerebellum - Journal of Neuroscience
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Revisiting the role of phospholipases C in virulence and the lifecycle of Mycobacterium tuberculosis - Nature
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Shedding of Trypanosoma cruzi Surface Molecules That Regulate Host Cell Invasion Involves Phospholipase C and Increases Upon Sterol Depletion - Frontiers
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Nucleocytoplasmic shuttling of phospholipase C‐δ1: A link to Ca2+ - Wiley Online Library
Why This Topic Is Trending
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Search Interest & Related Topics
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