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The physiology of decompression is the aspect of physiology which is affected by exposure to large changes in ambient pressure. It involves a complex interaction of gas solubility, partial pressures and concentration gradients, diffusion, bulk transport by perfusion, and bubble mechanics in living tissues. Gas is inhaled at ambient pressure, and some of this gas dissolves into the blood through the alveolar walls, is circulated, and diffuses into other fluids of perfused tissues. Inert gas continues to be taken up until the gas dissolved in the tissues is in a state of equilibrium with the gas in the lungs, or the ambient pressure is reduced until the inert gases dissolved in the tissues are at a higher concentration than the equilibrium state, and start diffusing out again.
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