Why is "Proliferating cell nuclear antigen" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-30 14:14:42
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.
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Trending Topic Today
Search Interest Perspective
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Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell - National Institutes of Health (.gov)
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Three proliferating cell nuclear antigen homologues from Metallosphaera sedula form a head-to-tail heterotrimer - Nature
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Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination - PNAS
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Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replication - ASM Journals
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Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation - Frontiers
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Proliferating cell nuclear antigen impairs the nuclear import of influenza A virus PB2 and suppresses virus replication - Wiley Online Library
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Comparative Analysis of Cluster of Differentiation 57 and Proliferating Cell Nuclear Antigen Expression in Different Grades of Oral Squamous Cell Carcinoma: An Immunohistochemical Study - Cureus
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Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis - PNAS
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Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex - Nature
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Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair - PNAS
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Localization and Quantification of Proliferating Cells During Rat Fracture Repair: Detection of Proliferating Cell Nuclear Antigen by Immunohistochemistry - Wiley Online Library
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Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia - Nature
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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks - PNAS
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ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study | Oncogene - Nature
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The structure of a ring-opened proliferating cell nuclear antigen–replication factor C complex revealed by fluorescence energy transfer - PNAS
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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells - PNAS
Why This Topic Is Trending
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Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.