Why is "Prostaglandin D2" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-04-02 16:19:29
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells. It is critical to development of allergic diseases such as asthma.
Research carried out in 1989 found PGD2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid).
Related Topics
Trending Topic Today
Search Interest Perspective
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Researchers reveal structural basis of prostaglandin D2 receptor DP1 activation and its implications for drug design - MSN
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Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1 - Nature
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Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma - Frontiers
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Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia - Science | AAAS
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Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling - PNAS
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Signaling on Macrophages and Microglia in Murine Coronavirus Encephalomyelitis - ASM Journals
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Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D - Wiley Online Library
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Prostaglandin D2 receptor antagonism: a novel therapeutic option for eosinophilic asthma? - The Lancet
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Prostaglandin D2 metabolite in urine is an index of food allergy - Scientific Reports - Nature
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The Leptomeninges Produce Prostaglandin D2 Involved in Sleep Regulation in Mice - Frontiers
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Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D - Wiley Online Library
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Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination - Nature
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, is specifically up-regulated in individuals in long-term remission from ulcerative colitis - PNAS
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metabolites are elevated with disease severity in patients with Fukuyama congenital muscular dystrophy - Nature
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amplifies lupus disease through basophil accumulation in lymphoid organs - Nature
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and CRTH2 as an approach to treat allergic diseases - Nature
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Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2 - Nature
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Prostaglandin D2 stimulates phenotypic changes in vascular smooth muscle cells | Experimental & Molecular Medicine - Nature
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receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung - Nature
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metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel - Nature
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Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo - PNAS
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PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations - Nature
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deficiency exacerbates food antigen-induced mast cell hyperplasia - Nature
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Drug Discovery to Reduce the Progression of Muscular Dystrophy by Targeting an Enzyme that Synthesizes Prostaglandin D2, Bioactive Fatty Acid - JAXA 有人宇宙技術部門
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Suppression of Niacin‐induced Vasodilation with an Antagonist to Prostaglandin D2 Receptor Subtype 1 - Wiley
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receptor deficiency attenuates the somnogenic effect of prostaglandin D - Nature
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induces programmed cell death in Trypanosoma brucei bloodstream form - Nature
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Prostaglandin D2 and Reproduction - Wiley Online Library
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The yin and yang of male pattern baldness - Science News
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New cause for male pattern baldness discovered: Is cure next? - KHOU
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The end of baldness? - theglobeandmail.com
Why This Topic Is Trending
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