Why is "Protein C" trending?

Search Interest Perspective

• Protein C-terminal variations impact proteostasis - Nature
• Congenital Protein C Deficiency Presenting as Neonatal Purpura Fulminans: A Report of Two Cases - Cureus
• AAV8-mediated mouse/human PROC expression rescues thrombophilia in hereditary protein C-deficient mice - Nature
• AAV8 Gene Therapy Reverses Protein C Deficiency - Bioengineer.org
• Compound Heterozygous Protein C Deficiency Presenting With Splenic Infarction After COVID-19: A Case Report - Cureus
• Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging - American Heart Association Journals
• Engraftment of wild-type alveolar type II epithelial cells in surfactant protein C deficient mice - Nature
• Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice - American Heart Association Journals
• Bioinformatic analysis of rare endothelial protein C receptor missense variants associated with coagulation and thrombophilia risk - Nature
• Cardiac myosin-binding protein-C levels are associated with severity and prognosis in stable coronary artery disease - Nature
• Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads - Nature
• Cardiac myosin binding protein-C phosphorylation as a function of multiple protein kinase and phosphatase activities - Nature
• Endothelial protein C receptor promotes retinal neovascularization through heme catabolism - Nature
• Role of the activation peptide in the mechanism of protein C activation - Nature
• Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia - Nature
• expression in plaque-associated macrophages in diabetes - Nature
• Diagnostic challenge of the newborn patients with heritable protein C deficiency - Nature
• Protein C -mannosylation - Nature
• Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure - Nature
• Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling - Nature
• Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin - Haematologica
• Protein C Pathway in Paediatric and Neonatal Sepsis - Frontiers
• Activation of protein C by the thrombin–thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C - PNAS
• Increased Activated Protein C Response Rates Reduce the Thrombotic Risk of Factor V Leiden Carriers But Not of Prothrombin 20210G>A Carriers | Circulation Research - American Heart Association Journals
• Endothelial Cell Protein C Receptor: - American Heart Association Journals
• Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial | Communications Medicine - Nature
• Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells - PNAS
• Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds - PNAS
• Protein C Deficiency Often Has No Symptoms: Alicia’s Story - National Blood Clot Alliance
• Prenatal genetic testing for familial severe congenital protein C deficiency - Nature
• Activated Protein C in Sepsis - Projects - Kim Lab - University of Rochester Medicine
• Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc - Nature
• Identification of multipotent mammary stem cells by protein C receptor expression - Nature
• Assessing the Use of Activated Protein C in the Treatment of Severe Sepsis - The New England Journal of Medicine
• Activated Protein C for Sepsis - The New England Journal of Medicine
• Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR) | Scientific Reports - Nature
• Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle - Rockefeller University Press
• Assessing the Use of Activated Protein C in the Treatment of Severe Sepsis - The New England Journal of Medicine
• Drotrecogin Alfa (Activated) in Adults with Septic Shock - The New England Journal of Medicine
• Prothrombin Arg541Trp Mutation Leads to Defective PC (Protein C) Pathway Activation and Constitutes a Novel Genetic Risk Factor for Venous Thrombosis - American Heart Association Journals
• The c.1243T>C mutation in the PROC gene is linked with inherited protein C deficiency and severe purpura fulminans - Wiley Online Library
• Direct Comparison of Cardiac Myosin-Binding Protein C With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction - American Heart Association Journals
• An Economic Evaluation of Activated Protein C Treatment for Severe Sepsis - The New England Journal of Medicine
• Outer membrane protein C is a protective and unique vaccine antigen against Shigella flexneri 3a - Nature
• A novel surfactant protein C mutation resulting in aberrant protein processing and altered subcellular localization causes infantile interstitial lung disease - Nature
• The endothelial protein C receptor plays an essential role in the maintenance of pregnancy - Science | AAAS
• Identification of serpins specific for activated protein C using a lysate-based screening assay - Nature
• Clinical and ultrastructural spectrum of diffuse lung disease associated with surfactant protein C mutations - Nature
• Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C - Nature
• Unravelling the therapeutic activity of activated protein C - Nature
• A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis - Nature
• Arterial Thrombus in a Protein C Deficient Patient - Cureus
• Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C - Nature
• Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc - PNAS
• Severe malaria is associated with parasite binding to endothelial protein C receptor - Nature
• Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis - The New England Journal of Medicine
• Activated protein C inhibits inflammasome activation in IRI - Nature
• Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S - Wiley Online Library
• Thrombin, protein C, and protein S values in mother-infant dyads in the postpartum period - Anales de Pediatría
• A Mutation in the Surfactant Protein C Gene Associated with Familial Interstitial Lung Disease - The New England Journal of Medicine
• LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification - Nature
• The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria - Nature
• Activated Protein C Resistance Assay and Factor V Leiden - The New England Journal of Medicine
• Endothelial cell protein C receptor and the risk of venous thrombosis - Haematologica
• Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice - Nature
• Hydroxychloroquine and Surfactant Protein C Deficiency - The New England Journal of Medicine
• Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage - Nature
• Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis - The New England Journal of Medicine
• Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow - Wiley Online Library
• Childhood stroke associated with protein C and S deficiency - Yu - 2024 - CNS Neuroscience & Therapeutics - Wiley Online Library
• Establishment of a new protein C detection system based on chromogenic substrate assay and its clinical diagnostic value for deep vein thrombosis - Wiley Online Library
• A New, Viable Approach in Hemophilia: Inhibition of Activated Protein C - Docwire News
• MiR-124 and miR-506 are involved in the decline of protein C in children with extra-hepatic portal vein obstruction - Nature
• Genetic Modifiers of Antihrombin, Protein C, and Protein S Plasma Levels - American Heart Association Journals
• Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate - The New England Journal of Medicine
• Antithrombin, PC (Protein C), and PS (Protein S): Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels - American Heart Association Journals
• A novel surfactant protein C L55F mutation associated with interstitial lung disease alters subcellular localization of proSP-C in A549 cells - Nature
• Intrapleural Adenoviral-mediated Endothelial Cell Protein C Receptor Gene Transfer Suppresses the Progression of Malignant Pleural Mesothelioma in a Mouse Model | Scientific Reports - Nature
• Thrombotic Occlusion of a Microvascular Anastomosis in a Resistance to Activated Protein C (APC) Patient with Incomplete Wound Healing after High Doses of Ascorbic Acid (Vitamin C) - SCIRP Open Access
• Mutations in the Gene for Cardiac Myosin-Binding Protein C and Late-Onset Familial Hypertrophic Cardiomyopathy - The New England Journal of Medicine
• Structural vulnerability in EPCR suggests functional modulation - Scientific Reports - Nature
• Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome - The New England Journal of Medicine
• Ex Vivo Modeling of the PC (Protein C) Pathway Using Endothelial Cells and Plasma: A Personalized Approach - American Heart Association Journals
• Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis - Nature
• Identification of blood vascular endothelial stem cells by the expression of protein C receptor - Nature
• Resistance to Activated Protein C as a Basis for Venous Thrombosis - The New England Journal of Medicine
• Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V - The New England Journal of Medicine
• Cavernous Transformation of Portal Vein in the Setting of Protein C and Anti-thrombin III Deficiency - Cureus
• The thrombomodulin–protein C system is essential for the maintenance of pregnancy - Nature
• Kallikrein augments the anticoagulant function of the protein C system in thrombin generation - Wiley Online Library
• Laboratory and genetic evaluation of antithrombin, protein C and protein S deficiency in patients following thrombotic events | Szymańska | Hematology in Clinical Practice - Via Medica Journals
• Chronic Non-cirrhotic Portal Vein Thrombosis with Cavernous Transformation Secondary to Protein C and S Deficiency - Cureus
• Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective - Nature
• Acquired activated protein-C resistance in pregnancy and association with increased thrombin generation and fetal weight - The Lancet
• Ceprotin arrives in Korea to treat extremely rare protein C deficiency - koreabiomed.com
• Activated Protein C Reduces the Severity of Compression-Induced Spinal Cord Injury in Rats by Inhibiting Activation of Leukocytes - Journal of Neuroscience
• Heterozygosity for ABCA3 Mutations Modifies the Severity of Lung Disease Associated with a Surfactant Protein C Gene ( SFTPC ) Mutation - Nature
• Congenital Protein C Deficiency and Venous Thromboembolism — A Study of Three Dutch Families - The New England Journal of Medicine
• Correlation between the Functional Assay for Activated Protein C Resistance and Factor V Leiden in the Neonate - Nature
• RETRACTED ARTICLE: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C - Nature