Why is "Protein splicing" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-03-31 11:56:52
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Protein splicing is an intramolecular reaction of a particular protein in which an internal protein segment is removed from a precursor protein with a ligation of C-terminal and N-terminal external proteins on both sides. The splicing junction of the precursor protein is mainly a cysteine or a serine, which are amino acids containing a nucleophilic side chain. The protein splicing reactions which are known now do not require exogenous cofactors or energy sources such as adenosine triphosphate (ATP) or guanosine triphosphate (GTP). Normally, splicing is associated only with pre-mRNA splicing. This precursor protein contains three segments—an N-extein followed by the intein followed by a C-extein. After splicing has taken place, the resulting protein contains the N-extein linked to the C-extein; this splicing product is also termed an extein.
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Trending Topic Today
Search Interest Perspective
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Comparative analysis of RNA versus protein splicing in dual AAV-mediated gene therapy in a mouse model of DFNB9 deafness - ScienceDirect.com
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SpliceBio Nabs $135 Million Series B To Advance Protein Splicing Medicines - BioSpace
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Directed evolution of ligand dependence: Small-molecule-activated protein splicing - PNAS
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Improved protein splicing through viral passaging - ASM Journals
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Protein Splicing of Inteins: A Powerful Tool in Synthetic Biology - Frontiers
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Conditional protein splicing of the Mycobacterium tuberculosis RecA intein in its native host - Nature
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Improved protein splicing using embedded split inteins - Gramespacher - 2018 - Protein Science - Wiley Online Library
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SpliceBio raises another $135M for eye disease gene therapy trials - firstwordpharma.com
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FDA clears SpliceBio's IND of gene therapy for Stargardt trial - Eyes On Eyecare
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Inteins—mechanism of protein splicing, emerging regulatory roles, and applications in protein engineering - Frontiers
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Structure of the branched intermediate in protein splicing - PNAS
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A cysteine-less and ultra-fast split intein rationally engineered from being aggregation-prone to highly efficient in protein trans -splicing - Nature
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Intein Inhibitors as Novel Antimicrobials: Protein Splicing in Human Pathogens, Screening Methods, and Off-Target Considerations - Frontiers
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Traceless protein splicing utilizing evolved split inteins - PNAS
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Conditional Protein Splicing Switch in Hyperthermophiles through an Intein-Extein Partnership - ASM Journals
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Activation of protein splicing with light in yeast - Nature
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Branching out of the intein active site in protein splicing - PNAS
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Protein trans-splicing: optimization of intein-mediated GFP assembly as a model for the development of gene therapy - Frontiers
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Branched intermediate formation stimulates peptide bond cleavage in protein splicing - Nature
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Post-translational enzyme activation in an animal via optimized conditional protein splicing - Nature
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Immune recognition of a human renal cancer antigen through post-translational protein splicing - Nature
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SpliceBio Initiates Dose-Expansion Portion of Phase 1/2 ASTRA Clinical Trial for SB-007, a Dual-AAV Gene Therapy for Stargardt Disease - BioSpace
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Development of a new caged intein for multi-input conditional translation of synthetic mRNA - Nature
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SpliceBio Raises $135 Million Series B - citybiz.co
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SpliceBio Appoints Aniz Girach as Chief Medical Officer - citybiz.co
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An expanded library of orthogonal split inteins enables modular multi-peptide assemblies - Nature
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News in brief: Splice junction function - ACS Publications
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Spanish biotech aims to disrupt gene therapy field - Health Tech World
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Protein splicing In Cis and In Trans - Saleh - 2006 - The Chemical Record - Wiley Online Library
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