Why is "Riboswitch" trending?

Search Interest Perspective

• A pinky promise explains a riboswitch puzzle - AIP.ORG
• Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12 - Nature
• Riboswitch-controlled lipid conversion enables functional membrane asymmetry in artificial cells - Nature
• Researchers use AI to develop RNA-based synthetic NAND switch in living cells - Phys.org
• Site‐Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting - Wiley Online Library
• Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases - Science | AAAS
• Modulating TPP riboswitch activity simultaneously enhances crop yield, nutritional quality and stress tolerance - Nature
• Co-transcriptional folding orchestrates sequential multi-effector sensing by a glycine tandem riboswitch - Nature
• Beyond the niche - unlocking the full potential of synthetic riboswitches - Nature
• tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch - Nature
• Designing molecular RNA switches with Restricted Boltzmann machines - Nature
• RNA folding kinetics control riboswitch sensitivity in vivo - Nature
• Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression - Nature
• Rational development of FMN-based orthogonal riboswitch that functions in response to specific non-cognate ligand - Nature
• A nascent riboswitch helix orchestrates robust transcriptional regulation through signal integration - Nature
• Targeting RNA with small molecules using state-of-the-art methods provides highly predictive affinities of riboswitch inhibitors | Communications Biology - Nature
• SAM-VI riboswitch structure and signature for ligand discrimination - Nature
• Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes - Nature
• Fluorescent riboswitch-controlled biosensors for the genome scale analysis of metabolic pathways - Nature
• riboswitches regulate genes for diverse physiological processes in bacteria - Nature
• Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution - Nature
• A natural riboswitch scaffold with self-methylation activity - Nature
• Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes - Nature
• Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system - Nature
• Structural basis for promiscuity in ligand recognition by yjdF riboswitch - Nature
• Characterization of a natural triple-tandem c-di-GMP riboswitch and application of the riboswitch-based dual-fluorescence reporter - Nature
• A Synthetic Riboswitch to Regulate Haloarchaeal Gene Expression - Frontiers
• Insights into the cotranscriptional and translational control mechanisms of the Escherichia coli tbpA thiamin pyrophosphate riboswitch | Communications Biology - Nature
• Unraveling RNA dynamical behavior of TPP riboswitches: a comparison between Escherichia coli and Arabidopsis thaliana - Nature
• Translational T-box riboswitches bind tRNA by modulating conformational flexibility - Nature
• Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution - Nature
• Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand - Nature
• Fluoride-Controlled Riboswitch-Based Dampening of Gene Expression for Cloning Potent Promoters - Frontiers
• 8-oxoguanine riboswitches in bacteria detect and respond to oxidative DNA damage - PNAS
• From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology - ASM Journals
• Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function - Nature
• An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system - Nature
• riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure - Nature
• T7 phage-assisted evolution of riboswitches using error-prone replication and dual selection - Nature
• Robust and tunable performance of a cell-free biosensor encapsulated in lipid vesicles - Science | AAAS
• Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag - Nature
• Phylogenomic and comparative analysis of the distribution and regulatory patterns of TPP riboswitches in fungi - Nature
• Dual-acting riboswitch control of translation initiation and mRNA decay - PNAS
• A Glycine-Dependent Riboswitch That Uses Cooperative Binding to Control Gene Expression - Science | AAAS
• A riboswitch gives rise to multi-generational phenotypic heterogeneity in an auxotrophic bacterium - Nature
• Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch - Nature
• An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch - Nature
• Riboswitch control of Rho-dependent transcription termination - PNAS
• Tuning a riboswitch response through structural extension of a pseudoknot - PNAS
• Magnesium ions mediate ligand binding and conformational transition of the SAM/SAH riboswitch - Nature
• The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold - Nature
• A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells - Nature
• The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts - Nature
• Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography - Nature
• A c-di-AMP riboswitch controlling kdpFABC operon transcription regulates the potassium transporter system in Bacillus thuringiensis - Nature
• Some general principles of riboswitch structure and interactions with small-molecule ligands - Cambridge University Press & Assessment
• A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control - Nature
• Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold | Nature Chemical Biology - Nature
• Hierarchical mechanism of amino acid sensing by the T-box riboswitch - Nature
• Local-to-global signal transduction at the core of a Mn - Nature
• The riboswitch-mediated control of sulfur metabolism in bacteria - PNAS
• Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA - Nature
• Single-molecule analysis reveals multi-state folding of a guanine riboswitch - Nature
• Switchable Fluorescent Light‐Up Aptamers Based on Riboswitch Architectures - Wiley Online Library
• An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch - Nature
• Potential effects of metal ion induced two-state allostery on the regulatory mechanism of add adenine riboswitch - Nature
• Structural determinants for ligand capture by a class II preQ1 riboswitch - PNAS
• Folding of a transcriptionally acting PreQ1 riboswitch - PNAS
• Exploring the structure, function of thiamine pyrophosphate riboswitch, and designing small molecules for antibacterial activity - Wakchaure - 2023 - WIREs RNA - Wiley Interdisciplinary Reviews
• Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape - Nature
• High-throughput identification of synthetic riboswitches by barcode-free amplicon-sequencing in human cells - Nature
• A Glycine Riboswitch in Streptococcus pyogenes Controls Expression of a Sodium:Alanine Symporter Family Protein Gene - Frontiers
• Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation - Nature
• Riboswitches for the alarmone ppGpp expand the collection of RNA-based signaling systems - PNAS
• Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch - Nature
• Flipping Riboswitches - ScienceDirect.com
• Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity - PNAS
• Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch - Nature
• High-resolution images reveal workings of a bacterial RNA riboswitch, a promising new target for antibiotics - Phys.org
• Structural basis of ligand binding by a c-di-GMP riboswitch - Nature
• RiboTALE: A modular, inducible system for accurate gene expression control - Nature
• An intermolecular base triple as the basis of ligand specificity and affinity in the guanine- and adenine-sensing riboswitch RNAs - PNAS
• Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands - Wiley Online Library
• Genetic dissection of regulation by a repressing and novel activating corrinoid riboswitch enables engineering of synthetic riboswitches - ASM Journals
• Sequestration of a two-component response regulator by a riboswitch-regulated noncoding RNA - Science | AAAS
• A riboswitch selective for the queuosine precursor preQ - Nature
• Dynamics Correlation Network for Allosteric Switching of PreQ1 Riboswitch | Scientific Reports - Nature
• Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch - Nature
• Riboswitch RSthiT as a Molecular Tool in Lactococcus lactis | Applied and Environmental Microbiology - ASM Journals
• A systematic search for RNA structural switches across the human transcriptome - Nature
• An Intrinsic Alkalization Circuit Turns on mntP Riboswitch under Manganese Stress in Escherichia coli - ASM Journals
• Riboswitch nanocarriers for adenine rescue metabolic disease phenotypes - Nature
• Fluoride resistance and transport by riboswitch-controlled CLC antiporters - PNAS
• Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch - Nature
• The glmS riboswitch integrates signals from activating and inhibitory metabolites in vivo - Nature
• Coenzyme B12 riboswitches are widespread genetic... : Nucleic Acids Research - Ovid
• ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands - Nature
• T box riboswitches in Actinobacteria: Translational regulation via novel tRNA interactions - PNAS
• Structure of the SAM-II riboswitch bound to S -adenosylmethionine - Nature
• Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch - PNAS