Why is "Sphingolipid" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-19 06:03:55
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Sphingolipid entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-19 and was most recently seen on 2026-05-19.
Wikipedia Overview
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature. These compounds play important roles in signal transduction and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with a terminal hydroxyl group is a ceramide. Other common groups bonded to the terminal oxygen atom include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids.
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Trending Topic Today
Search Interest Perspective
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DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis - Nature
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Cholesterol depletion activates trafficking-coupled sphingolipid synthesis - Rockefeller University Press
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Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes - Science | AAAS
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Sphingolipid metabolism and hematologic disorders: current understanding and future directions - Frontiers
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Brain Pathology | ISN Neuropathology Journal - Wiley Online Library
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The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations - Nature
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LC–MS/MS Profiling Reveals Age- and Sex-Dependent Trends in Blood Sphingolipids - Chromatography Online
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Sphingolipids Market Forecast 2025-2035: Global Value to Reach USD 1,145.6 Million by 2035 at 5.1% CAGR - Yahoo Finance
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Broadening Research on the Role of Sphingolipids in Cancer - SBU News
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Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division - Rockefeller University Press
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Impact of Nutrition on Sphingolipid‐Regulated Physiology: A Review - Wiley Online Library
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Altered sphingolipid profile in primary biliary cholangitis: associations with fibrosis and inflammation - Nature
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A sphingolipid-derived paclitaxel nanovesicle enhances efficacy of combination therapies in triple-negative breast cancer and pancreatic cancer - Nature
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A sphingolipid-derived paclitaxel nanovesicle for improved cancer therapy - Nature
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Lifespan trajectories of serum sphingolipids in a clinically healthy Swiss population, towards precision medicine in cardiometabolic health assessment - Nature
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Sphingolipid signaling links elastin deficiency to arterial hyper-muscularization and congenital heart disease - Nature
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The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis - Nature
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Sphingolipids as indicators of exposure to long-term air pollution: a targeted metabolomics approach - Nature
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Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens - Nature
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Phytosphingosine, a sphingolipid isolated from fungal endophyte Penicillium oxalicum , exerts cytotoxic effects against breast cancer cells and shows blood compatibility - Nature
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Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation - ASM Journals
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Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions - Frontiers
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A Lipid-Based Approach to Stratification & Treatment Resistance in AML - UVA Health
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Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways - Nature
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Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development - Wiley Online Library
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Lipid Ratio Score May Predict Asthma Exacerbation Risk - Medscape
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Host sphingolipids support Plasmodium berghei liver stage development - ASM Journals
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Microbiota–Sphingolipid Pathway in Generalized Epilepsy: Evidence from Mendelian Randomization and Clinical Metabolomics - Frontiers
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Blood lipid–hormone ratios predict future asthma attacks years in advance - News-Medical
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Sphingolipid-rich supplement may ameliorate age-related metabolic dysfunction: Study - NutraIngredients.com
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Sphingolipids Market to Reach USD 1,224.8 Million by 2036, Driven by Therapeutic Research Expansion and Rising Demand for High-Purity Lipid Standards - Morningstar
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Intricate Regulation of Sphingolipid Biosynthesis: An In-Depth Look Into ORMDL-Mediated Regulation of Serine Palmitoyltransferase - Wiley Online Library
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DKC1 Protein Disrupts Sphingolipid Biosynthesis, Promoting Colorectal Cancer Growth - geneonline.com
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Editorial: The role of glycolipids and sphingolipids in the differentiation and function of innate immune cells - Frontiers
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Host sphingolipids support Plasmodium berghei liver stage development - ASM Journals
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Self-Assembly of Accumulated Sphingolipids into Cytotoxic Fibrils in Globoid Cell Leukodystrophy and Their Inhibition by Small Molecules In Vitro - ACS Publications
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Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis - American Heart Association Journals
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Lipidomic Analysis of Esophageal Epithelia Reveals a Distinctive Sphingolipid Profile in Eosinophilic Esophagitis - Wiley Online Library
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Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis - Nature
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DKC1 Drives Colorectal Cancer via Sphingolipid Disruption - Bioengineer.org
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IL-10 constrains sphingolipid metabolism to limit inflammation - Nature
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Functional roles of sphingolipids in immunity and their implication in disease - Nature
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Lipidomic Analysis of Esophageal Epithelia Reveals a Distinctive Sphingolipid Profile in Eosinophilic Esophagitis - Wiley Online Library
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An intestinal sphingolipid confers intergenerational neuroprotection - Nature
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Exploring Sphingolipid Implications in Neurodegeneration - Frontiers
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Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment - Rockefeller University Press
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Serine restriction alters sphingolipid diversity to constrain tumour growth - Nature
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Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model - Nature
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Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia - Nature
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Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis - Nature
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Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis - Rockefeller University Press
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The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy - Nature
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Development of an advanced liquid chromatography–tandem mass spectrometry measurement system for simultaneous sphingolipid analysis - Nature
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A sphingolipid rheostat controls apoptosis versus apical cell extrusion as alternative tumour-suppressive mechanisms - Nature
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Essential Role of Endothelial Sphingolipid Biosynthesis in Cerebrovascular Homeostasis - American Heart Association Journals
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Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy - Science | AAAS
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Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes - ASM Journals
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Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis - Nature
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Plasma membrane effects of sphingolipid-synthesis inhibition by myriocin in CHO cells: a biophysical and lipidomic study - Nature
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Sphingolipids in neurodegenerative diseases - Frontiers
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Nanoscale imaging of bacterial infections by sphingolipid expansion microscopy - Nature
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CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants - Nature
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Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia - Nature
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Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis - Nature
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Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer - Nature
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The link between the sphingolipid rheostat and obstructive sleep apnea - Scientific Reports - Nature
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Ceramides and other sphingolipids as drivers of cardiovascular disease - Nature
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Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans - Nature
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Nicotine Consumption Improves Motor Functions in Male Mice - Lifespan Research Institute
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Convergence of sphingolipid desaturation across over 500 million years of plant evolution - Nature
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Sphingolipid accumulation causes mitochondrial dysregulation and cell death - Nature
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Link Between Ceramide Transport and Cell Senescence Could Inform Aging Biology Research - Genetic Engineering and Biotechnology News
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A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice - Nature
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Role of sphingolipid metabolites in the homeostasis of steroid hormones and the maintenance of testicular functions - Frontiers
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Sphingolipid metabolites in inflammatory disease - Nature
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Sphingolipid composition of circulating extracellular vesicles after myocardial ischemia - Nature
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Candida albicans gains azole resistance by altering sphingolipid composition - Nature
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Sphingolipid lysosomal storage disorders - Nature
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Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson’s disease - medRxiv
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The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens - Nature
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Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network - Nature
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Sphingolipid signaling in kidney diseases - American Physiological Society Journal
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The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation - Nature
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Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function - Nature
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Suppression of de novo sphingolipid biosynthesis mitigates sarcopenia - Nature
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Sphingolipid biosynthesis modulates plasmodesmal ultrastructure and phloem unloading - Nature
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Alterations of Sphingolipid Metabolism in Different Types of Polycystic Ovary Syndrome - Nature
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Sphingolipids, mycobacteria and host: Unraveling the tug of war - Frontiers
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Diverse Facets of Sphingolipid Involvement in Bacterial Infections - Frontiers
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Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults - Nature
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Circulating Ceramides- Are Origins Important for Sphingolipid Biomarkers and Treatments? - Frontiers
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Principles of bioactive lipid signalling: lessons from sphingolipids - Nature
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Sphingolipid-dependent Dscam sorting regulates axon segregation - Nature
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Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology - Frontiers
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The pleiotropic roles of sphingolipid signaling in autophagy - Nature
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Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer’s disease transgenic mice by functioning as a metabolic probe | Scientific Reports - Nature
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The sphingolipid biosynthetic enzyme Sphingolipid delta8 desaturase is important for chilling resistance of tomato - Nature
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Sphingolipid metabolism and signaling in cardiovascular diseases - Frontiers
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A multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling | Scientific Reports - Nature
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Serum sphingolipid profiling as a novel biomarker for metabolic syndrome characterization - Frontiers
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.