Why is "Stapled peptide" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-13 20:38:25
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Stapled_peptide entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-13 and was most recently seen on 2026-03-13.
Wikipedia Overview
A stapled peptide is a modified peptide, typically in an alpha-helical conformation, that is constrained by a synthetic brace ("staple"). The staple is formed by a covalent linkage between two amino acid side-chains, forming a peptide macrocycle. Staples, generally speaking, refer to a covalent linkage of two previously independent entities. Peptides with multiple, tandem staples are sometimes referred to as stitched peptides. Among other applications, peptide stapling is notably used to enhance the pharmacologic performance of peptides.
Read more on Wikipedia →Related Topics
- Agonist
- Alpha helix
- Amino acid
- Beta-peptide
- Bibcode (identifier)
- Binding affinity
- Biopharmaceutical
- Cell membrane
- Clinical trial
- Conformational entropy
Trending Topic Today
Search Interest Perspective
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Study on the design, synthesis and activity of MDM2/MDMX anti-tumor stapled peptide PROTAC - Nature
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Stapled Peptide Nanoparticle Combo Prevents RSV Infection - respiratory-therapy.com
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Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor - Science | AAAS
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Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma - ACS Publications
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A Stapled Peptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase Subunits METTL3 and METTL14 for Cancer Therapy - Wiley Online Library
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Inhaled Stapled Peptide Reduces Airway Obstruction in Preclinical Study - Genetic Engineering and Biotechnology News
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An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer - Nature
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A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection - Science | AAAS
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Aileron straps in for 2025 with a new name: Rein Therapeutics - Fierce Pharma
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Computational design of stapled peptide inhibitor against SARS-CoV-2 receptor binding domain - Wiley Online Library
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Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic - PNAS
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Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer - Nature
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A Stapled Peptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase Subunits METTL3 and METTL14 for Cancer Therapy - Wiley Online Library
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Stapled peptide reactivates p53 - Nature
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Designing stapled peptides to inhibit protein-protein interactions: An analysis of successes in a rapidly changing field - Wiley Online Library
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Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices - Nature
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Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists - Nature
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Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer - Nature
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Aileron Therapeutics Closes $40 Million Series D Financing - Fierce Biotech
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.