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This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Theophylline/ephedrine entered the ranking for the first time today at position #. This is its highest position ever recorded.
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-13 and was most recently seen on 2026-05-13.
Theophylline ephedrine, or theophylline/ephedrine, sold under the brand name Franol among others, is a fixed-dose combination formulation of theophylline, an adenosine receptor antagonist, and ephedrine, a norepinephrine releasing agent and indirectly acting sympathomimetic agent, which has been used as a bronchodilator in the treatment of asthma and as a nasal decongestant. It was first studied and used to treat asthma in the 1930s or 1940s and combinations of the two drugs subsequently became widely used. A ratio of 5:1 theophylline to ephedrine is usually used in combinations of the drugs. Later research found that the combination was no more effective for asthma than theophylline alone but produced more side effects.
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.