Why is "Thiazolidinedione" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-03-28 14:38:18
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
The thiazolidinediones, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in the treatment of diabetes mellitus type 2 that were introduced in the late 1990s. As of 2024, there are two FDA-approved drugs in this class, pioglitazone and rosiglitazone.
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Search Interest Perspective
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Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPARγ modulator - Nature
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GLP-1 RA, Thiazolidinedione Combo Linked to Lower Mortality in Type 2 Diabetes - AJMC
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Thiazolidinedione Derivatives as Anticancer Agents: Synthetic Strategies, SAR, and Therapeutic Potential - Wiley Online Library
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Dongkook Pharm Moves to Develop Generic of Chong Kun Dang Diabetes Drug Duvie - aju press
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Oral antihyperglycemic therapy for type 2 diabetes mellitus - CMAJ
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Understanding Contemporary Use of Thiazolidinediones | Circulation: Heart Failure - American Heart Association Journals
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GLP-1s and Thiazolidinediones May Lower Heart Risk in T2D - Medscape
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Structure–Activity Relationship Study and Design Strategies of Hydantoin, Thiazolidinedione, and Rhodanine-Based Kinase Inhibitors: A Two-Decade Review | ACS Omega - ACS Publications
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Thiazolidinediones for Nonalcoholic Steatohepatitis — Promising but Not Ready for Prime Time - NEJM
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Etiology of Drug-Induced Edema: A Review of Dihydropyridine, Thiazolidinedione, and Other Medications Causing Edema - Cureus
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Thiazolidinedione use and risk of Parkinson’s disease in patients with type 2 diabetes mellitus - Nature
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Preparation of PIE‐Active Poly(2,4‐thiazolidinediones) by Oxidative Polymerization and Simultaneous Specific Detection of Cu2+/Co2+ Ions - Wiley Online Library
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Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance - NEJM
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Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes - Nature
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Thiazolidinediones - NEJM
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Design, synthesis and mechanistic study of N-4-Piperazinyl Butyryl Thiazolidinedione derivatives of ciprofloxacin with Anticancer Activity via Topoisomerase I/II inhibition - Nature
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CADD based designing and biological evaluation of novel triazole based thiazolidinedione coumarin hybrids as antidiabetic agent - Nature
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Different sites of actions make different responses to thiazolidinediones between mouse and rat models of fatty liver - Nature
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Thiazolidinediones increase fracture risk - Nature
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Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis - Nature
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Molecular Toxicological Alterations in the Mouse Hearts Induced by Sub‐Chronic Thiazolidinedione Drugs Administration - Jarrar - - Fundamental & Clinical Pharmacology - Wiley Online Library
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Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists - Nature
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Thiazolidinedione as an alternative to facilitate oral administration in geriatric patients with Alzheimer's disease - ScienceDirect.com
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This Outdated Diabetes Drug Still Has Something to Offer - UC San Diego Today
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The effect of thiazolidinediones on BMD and osteoporosis - Nature
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Gastroprotective effect of rhodanine and 2,4-thiazolidinediones scaffolds in rat stomachs by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins - Nature
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Diabetes Medications Increase Fracture Risk - Docwire News
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β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment - Nature
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Indole clubbed 2,4-thiazolidinedione linked 1,2,3-triazole as a potent antimalarial and antibacterial agent against drug-resistant strain and molecular modeling studies - Wiley Online Library
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Thiazolidinedione Use Linked to Diabetic Macular Edema - Medical Professionals Reference
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Evaluating the Antivirulence Effects of New Thiazolidinedione Compounds Against Pseudomonas aeruginosa PAO1 - Sage Journals
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Thiazolidinediones and clinical outcomes in type 2 diabetes - The Lancet
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New study could lead to diabetes treatment with fewer side effects - Drug Target Review
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Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption - Nature
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Risk of Fracture with Thiazolidinediones: An Individual Patient Data Meta-Analysis - Frontiers
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Cyclic Stretch Facilitates Myogenesis in C2C12 Myoblasts and Rescues Thiazolidinedione-Inhibited Myotube Formation - Frontiers
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Ensuring drug safety: lessons from the thiazolidinediones - The Lancet
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Thiazolidinediones for NASH—one pill doesn't fix everything - Nature
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Thiazolidinediones for Nonalcoholic Steatohepatitis — Promising but Not Ready for Prime Time - NEJM
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Researchers Find New Anti-Aging Properties in Old Diabetes Drugs - NYU Langone Health
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Diabetics May Be at Lower Parkinson’s Risk if Being Treated with Thiazolidinediones, Study Suggests - Parkinson's News Today
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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes - NEJM
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Decoding the Genetic Blueprint: Advancing Personalized Medicine in Type 2 Diabetes through Pharmacogenomics - Via Medica Journals
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Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats - Nature
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Triple combination therapy may be optimal for CV protection in type 2 diabetes - Healio
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Investigators probe edema side effect of popular diabetes drugs - Vanderbilt Health News
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Depot-related and thiazolidinedione-responsive expression of uncoupling protein 2 (UCP2) in human adipocytes - Nature
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Pioglitazone Use, Bladder Cancer Linked - Renal and Urology News
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Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs - Nature
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Pioglitazone Shows No Significant Association With Bladder Cancer Risk - CancerNetwork
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Metformin and thiazolidinedione combo most effective for preventing AF in type 2 diabetes - Medical Dialogues
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Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials - Nature
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Drug Insight: thiazolidinediones and diabetic nephropathy—relevance to renoprotection - Nature
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Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro - Nature
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Precision medicine approach improves HbA - Nature
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Type 2 Diabetes Mellitus: ACP Releases Updated Recommendations for Oral Pharmacologic Treatment - American Academy of Family Physicians | AAFP
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Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy - NEJM
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Two diabetes drug classes can increase, maintain beta-cell function - Healio
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FDA Removes Restrictions on Avandia, But is it Too Little Too Late? - diaTribe
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Revisiting the Avandia Scare: Results from the RECORD Trial - diaTribe
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Certain Antidiabetic Agents Linked to Increased Pneumonia Risk - Medical Professionals Reference
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Comparative Safety of Dipeptidyl Peptidase-4 Inhibitors Versus Sulfonylureas and Other Glucose-lowering Therapies for Three Acute Outcomes - Nature
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Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome - Nature
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Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis - CMAJ
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Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects - ScienceDirect.com
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Pioglitazone versus Rosiglitazone: Effects on Lipids, Lipoproteins, and Apolipoproteins in Head‐to‐Head Randomized Clinical Studies - Deeg - 2008 - PPAR Research - Wiley Online Library
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A Retrospective Analysis of Lobeglitazone as an Add-On to Existing Glucose-Lowering Therapy in Indian Adults with Suboptimally Controlled Type 2 Diabetes for Its Clinical Effectiveness: A Real-World Clinical Experience | Baidya | Clinical Diabetology - Via Medica Journals
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Pioglitazone after Ischemic Stroke or Transient Ischemic Attack - NEJM
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PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis - Frontiers
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FDA Approves 3 New Diabetes Treatments - Medical Professionals Reference
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Link between diabetes drug and bladder cancer confirmed - McGill University
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Responding to an FDA Warning — Geographic Variation in the Use of Rosiglitazone - NEJM
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PPARγ signaling and emerging opportunities for improved therapeutics - ScienceDirect.com
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Jeil Pharmaceutical launches dapagliflozin+pioglitazone combo for type-2 diabetes - koreabiomed.com
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Insulin-sensitizing agents in women with polycystic ovary syndrome - ScienceDirect.com
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Could a diabetes drug help to prevent vascular dementia? - Alzheimer's Research UK
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Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis - Nature
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American Diabetes Association Release: Pioglitazone Decreases Type 2 Diabetes Risk In Stroke Patients With Insulin Resistance - BioSpace
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Effect of Troglitazone in Insulin-Treated Patients with Type II Diabetes Mellitus - NEJM
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Diabetes drug pioglitazone (Actos): risk of fracture - CMAJ
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Researchers Suggest Role for Hypothalamic PPAR-gamma in Diabetes Drug-Related Weight Gain - Genetic Engineering and Biotechnology News
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Akums launches drug combo for Type-2 Diabetes - ET Pharma
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Oral antihyperglycemic therapy for type 2 diabetes mellitus - CMAJ
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Adverse Drugs Reaction and Prescribing Pattern of Antidiabetic Medications in Type 2 Diabetes Patients: An Observational Ambispective Study - Via Medica Journals
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Link between diabetes drug and risk of bladder cancer confirmed - imt.ie
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Glenmark introduces Lobeglitazone for uncontrolled Type 2 diabetes in India - BioSpectrum India
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Glenmark to launch Lobeglitazone in India for T2 diabetes in adults - ET HealthWorld
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Glenmark launches drug for uncontrolled diabetes in India - Mint
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Scotland backs saxagliptin for type-2 diabetes - GPonline
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Glenmark launches drug to treat patients with insulin-resistant diabetes - Zee Business
Why This Topic Is Trending
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Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.