Why is "Zinc finger" trending?
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- Date: 2026-03-30 23:49:59
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Wikipedia Overview
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilize the fold. The term zinc finger was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA. However, it has been found to encompass a wide variety of differing protein structures in eukaryotic cells. Xenopus laevis TFIIIA was originally demonstrated to contain zinc and require the metal for function in 1983, the first such reported zinc requirement for a gene regulatory protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domain proteins.
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Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila - Science | AAAS
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Zinc finger domains bind low-complexity domain polymers - Nature
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How a tiny zinc finger protein determines tomato fruit size | Newswise - Newswise
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How proteins bind to RNA: The dual mechanism of zinc fingers and disordered regions - Phys.org
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AI-Enhanced Zinc Finger Proteins May Reduce Immune Risks in Cell and Gene Therapies - Genetic Engineering and Biotechnology News
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Tiny Zinc-Finger Protein Key to Giant Tomatoes- Crop Biotech Update (October 29, 2025) | Gene Editing Supplement - ISAAA.org
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The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements - Nature
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TANDEM ZINC-FINGER/PLUS3 integrates light signaling and flowering regulatory pathways at the chromatin level - Wiley
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AI used to design immune-safe 'zinc finger' proteins for gene therapy - Phys.org
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Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice - Nature
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GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion - Nature
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The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor - Nature
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Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome - Nature
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Zinc Finger Protein 82 regulates p53 protein stability through histone deacetylase and enhances neo-adjuvant chemotherapy in esophageal cancer - Nature
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A novel zinc finger protein gene signature for prognostic prediction, tumor microenvironment characterization, and therapeutic response in uterine corpus endometrial carcinoma - Nature
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Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs - Nature
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Zinc-finger proteins in health and disease - Cell Death Discovery - Nature
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A universal deep-learning model for zinc finger design enables transcription factor reprogramming - Nature
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Zinc finger proteins: guardians of genome stability - Frontiers
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Activation of recombinases at specific DNA loci by zinc-finger domain insertions - Nature
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Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells - Nature
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Cooperative dynamics of PARP-1 zinc-finger domains in the detection of DNA single-strand breaks - Nature
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The role of zinc finger proteins in malignant tumors - Zhao - 2023 - Wiley
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Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo - Nature
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Zinc Finger Transcription Factors: The On/Off Switch for Genes Inspired by Frogs - Pfizer
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Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance - Nature
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Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation - Nature
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Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos - PNAS
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RING Zinc Finger Proteins in Plant Abiotic Stress Tolerance - Frontiers
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Functional anatomy of zinc finger antiviral protein complexes - Nature
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A genome-wide comparative evolutionary analysis of zinc finger-BED transcription factor genes in land plants - Nature
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Structure-based design of an RNA-binding zinc finger - PNAS
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Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases - Nature
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Zinc Finger Proteins in Neuro-Related Diseases Progression - Frontiers
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Genome editing with engineered zinc finger nucleases - Nature
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New zinc finger model shows promise for gene therapy - EurekAlert!
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GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail - Nature
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A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes - Nature
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C2H2 Zinc Finger Proteins: Master Regulators of Abiotic Stress Responses in Plants - Frontiers
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Diversifying the structure of zinc finger nucleases for high-precision genome editing - Nature
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Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences - PNAS
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Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease - Nature
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C2H2 zinc finger proteins greatly expand the human regulatory lexicon - Nature
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Zinc-finger PARP proteins ADP-ribosylate alphaviral proteins and are required for interferon-γ–mediated antiviral immunity - Science | AAAS
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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase - PNAS
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Persistent repression of tau in the brain using engineered zinc finger protein transcription factors - Science | AAAS
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Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice - PNAS
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Recognition of polyadenosine RNA by zinc finger proteins - PNAS
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Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function - PNAS
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A zinc finger transcription factor enables social behaviors while controlling transposable elements and immune response in prefrontal cortex - Nature
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Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway - Frontiers
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Rational attenuation of RNA viruses with zinc finger antiviral protein - Nature
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Engineering of Zinc Finger Nucleases Through Structural Modeling Improves Genome Editing Efficiency in Cells - Wiley
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The apple DNA-binding one zinc-finger protein MdDof54 promotes drought resistance - Nature
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Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution - Nature
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Modulation of host gene expression by the zinc finger antiviral protein - PNAS
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Zinc Finger Protein Znf296 Is a Cardiac-Specific Splicing Regulator Required for Cardiomyocyte Formation - ScienceDirect.com
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Zinc-Finger Protein ZFP488 Regulates the Timing of Oligodendrocyte Myelination and Remyelination - Journal of Neuroscience
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Selective targeting of genes regulated by zinc finger proteins in endometriosis and endometrioid adenocarcinoma by zinc niflumato complex with neocuproine - Nature
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zinc finger proteins in anthracnose development and dissemination on pepper fruits by Colletotrichum scovillei - ASM Journals
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Multifaceted roles of zinc finger proteins in regulating various agronomic traits in rice - Frontiers
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GhWIP2, a WIP zinc finger protein, suppresses cell expansion in Gerbera hybrida by mediating crosstalk between gibberellin, abscisic acid, and auxin - Wiley
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Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate - PNAS
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Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury - ScienceDirect.com
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AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion - Nature
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Classification of the treble clef zinc finger: noteworthy lessons for structure and function evolution - Nature
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Two zinc finger proteins with functions in m - Nature
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Genomics: the leading companies in zinc-finger nucleases revealed - Pharmaceutical Technology
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The Cys4 zinc finger of bacteriophage T7 primase in sequence-specific single-stranded DNA recognition - PNAS
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The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse - Nature
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Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining - Nature
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Zinc-finger Protein Therapy Shows Potential in Angelman Mouse Model - Angelman Syndrome News
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The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 UL5 Transcripts - ASM Journals
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Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor) | Signal Transduction and Targeted Therapy - Nature
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Giving Huntington's disease the finger? Two teams report success for zinc-finger drugs in cells and mice - HDBuzz
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Targeted mutagenesis using zinc-finger nucleases in Arabidopsis - PNAS
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Model transforms zinc finger design into 'push-button' technology - BioWorld News
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GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network - Nature
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DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover - Phys.org
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KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks - Nature
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A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125 - Nature
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Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN - Science | AAAS
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Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor - Nature
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Zinc finger transcription factor ZFP1 is associated with growth, conidiation, osmoregulation, and virulence in the Polygonatum kingianum pathogen Fusarium oxysporum - Nature
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The insulator functions of the Drosophila polydactyl C2H2 zinc finger protein CTCF: Necessity versus sufficiency - Science | AAAS
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Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation - Nature
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Zinc Finger Design AI Tool Opens Door to Large-Scale Gene Therapies - Genetic Engineering and Biotechnology News
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The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation - Nature
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Zinc-finger antiviral protein-mediated inhibition of porcine epidemic diarrhea virus growth is antagonized by the coronaviral nucleocapsid protein - Frontiers
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High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases - PNAS
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Highly efficient endonucleolytic cleavage of RNA by a Cys2His2 zinc-finger peptide - PNAS
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Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons - Science | AAAS
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Use of Zinc Finger Proteins Shows Promise in Huntington's Mice |... - huntingtonsdiseasenews.com
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Zinc-finger nucleases: how to play two good hands - Nature
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Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4 - Frontiers
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Exploring the DNA-binding specificities of zinc fingers with DNA microarrays - PNAS
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The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA - PNAS
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Researchers use machine-learning modeling tools to improve zinc-finger nuclease editing technology - Phys.org
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An improved zinc-finger nuclease architecture for highly specific genome editing - Nature
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Zinc-finger antiviral protein mediates retinoic acid inducible gene I–like receptor-independent antiviral response to murine leukemia virus - PNAS
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