Why is "Activated protein C" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-15 08:58:17
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Activated_protein_C entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-15 and was most recently seen on 2026-03-15.
Wikipedia Overview
Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, that is, an inactive enzyme. The activated form plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the permeability of blood vessel walls in humans and other animals. Activated protein C (APC) performs these operations primarily by proteolytically inactivating proteins Factor Va and Factor VIIIa. APC is classified as a serine protease since it contains a residue of serine in its active site. In humans, protein C is encoded by the PROC gene, which is found on chromosome 2.
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Trending Topic Today
Search Interest Perspective
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Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging - American Heart Association Journals
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Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin - Haematologica
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Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling - Nature
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Drotrecogin Alfa (Activated) in Adults with Septic Shock - The New England Journal of Medicine
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Activated Protein C in Sepsis - Projects - Kim Lab - University of Rochester Medicine
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A New, Viable Approach in Hemophilia: Inhibition of Activated Protein C - Docwire News
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Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds - PNAS
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Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S - Wiley Online Library
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Close link between anti phosphatidyl-serine/prothrombin antibodies, Lupus Anticoagulant and activated protein C resistance in tetra antiphospholipid antibody-positive subjects. - Physician's Weekly
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expression in plaque-associated macrophages in diabetes - Nature
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Increased Activated Protein C Response Rates Reduce the Thrombotic Risk of Factor V Leiden Carriers But Not of Prothrombin 20210G>A Carriers | Circulation Research - American Heart Association Journals
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Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis - The New England Journal of Medicine
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Impaired in vivo activated protein C response rates indicate a thrombophilic phenotype in inherited thrombophilia - Haematologica
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Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells - PNAS
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Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia - Nature
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An Economic Evaluation of Activated Protein C Treatment for Severe Sepsis - The New England Journal of Medicine
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Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C - Nature
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Activated Protein C for Sepsis - The New England Journal of Medicine
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Assessing the Use of Activated Protein C in the Treatment of Severe Sepsis - The New England Journal of Medicine
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Identification of serpins specific for activated protein C using a lysate-based screening assay - Nature
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Unravelling the therapeutic activity of activated protein C - Nature
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Activated protein C inhibits inflammasome activation in IRI - Nature
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Thrombotic Occlusion of a Microvascular Anastomosis in a Resistance to Activated Protein C (APC) Patient with Incomplete Wound Healing after High Doses of Ascorbic Acid (Vitamin C) - SCIRP Open Access
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Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage - Nature
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Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc - PNAS
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Activated Protein C Resistance Assay and Factor V Leiden - The New England Journal of Medicine
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3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice - Nature
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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis - Nature
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Resistance to Activated Protein C as a Basis for Venous Thrombosis - The New England Journal of Medicine
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Activated Protein C Resistance Assay and Factor V Leiden - The New England Journal of Medicine
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Activated Protein C Reduces the Severity of Compression-Induced Spinal Cord Injury in Rats by Inhibiting Activation of Leukocytes - Journal of Neuroscience
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Acquired activated protein-C resistance in pregnancy and association with increased thrombin generation and fetal weight - The Lancet
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Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study - The Lancet
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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective - Nature
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Correlation between the Functional Assay for Activated Protein C Resistance and Factor V Leiden in the Neonate - Nature
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Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice | Scientific Reports - Nature
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Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V - The New England Journal of Medicine
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RETRACTED ARTICLE: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C - Nature
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Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V - The New England Journal of Medicine
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Role of the activation peptide in the mechanism of protein C activation - Nature
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Low-Dose Heparin for Severe Sepsis - The New England Journal of Medicine
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RECOMBINANT HUMAN ACTIVATED PROTEIN C (XIGRIS®) - Levi - 2002 - International Journal of Clinical Practice - Wiley Online Library
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The rise and fall of drotrecogin alfa (activated) - The Lancet
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.